High-sensitivity Lens culinaris agglutinin-reactive alpha-fetoprotein assay predicts early detection of hepatocellular carcinoma
Background Prognosis of patients with hepatocellular carcinoma (HCC) remains poor because HCC is frequently diagnosed late. Therefore, regular surveillance has been recommended to detect HCC at the early stage when curative treatments can be applied. HCC biomarkers, including Lens culinaris agglutin...
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| Veröffentlicht in: | Journal of gastroenterology 2014-03, Vol.49 (3), p.555-563 |
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| creator | Kumada, Takashi Toyoda, Hidenori Tada, Toshifumi Kiriyama, Seiki Tanikawa, Makoto Hisanaga, Yasuhiro Kanamori, Akira Tanaka, Junko Kagebayashi, Chiaki Satomura, Shinji |
| description | Background
Prognosis of patients with hepatocellular carcinoma (HCC) remains poor because HCC is frequently diagnosed late. Therefore, regular surveillance has been recommended to detect HCC at the early stage when curative treatments can be applied. HCC biomarkers, including
Lens culinaris
agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3), are widely used for surveillance in Japan. A newly developed immunoassay system measures AFP-L3 % with high sensitivity. This retrospective study aimed to evaluate clinical utility of high-sensitivity AFP-L3 (hs-AFP-L3) as a predictor of early stage HCC in surveillance at a single site.
Methods
Of consecutive 2830 patients in the surveillance between 2000 and 2009, 104 HCC-developed and 104 non-HCC patients were selected by eligibility criteria and propensity score matching. Samples were obtained from the HCC patients who had blood drawn annually for 3 years prior to HCC diagnosis.
Results
In the present study, hs-AFP-L3 was elevated 1 year prior to diagnosis in 34.3 % of patients. The survival rate of patients with the hs-AFP-L3 ≥ 7 % at 1 year prior to diagnosis was significantly lower than that of patients with hs-AFP-L3 |
| doi_str_mv | 10.1007/s00535-013-0883-1 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3953543</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714584231</galeid><sourcerecordid>A714584231</sourcerecordid><originalsourceid>FETCH-LOGICAL-c627t-f86c21f90bbb16ec5ecc8ccbe63c9ee21d5824fd8abf1404f25c997685b793ee3</originalsourceid><addsrcrecordid>eNp1kk9v1DAQxSMEokvhA3BBlrhwSfHfOLkgVRVtkVbiAmfLccZZV1k72E6lvfWj47CltAjkg62Z33vWjF5VvSX4jGAsPyaMBRM1JqzGbctq8qzaEF4qoqP0ebXBHec1IZKfVK9SusEFxKJ9WZ1QjoUkDdtUd9du3NUJfHLZ3bp8QNvyRmaZnNfRJaTHcVqy887XEbQpECA9zTtdW8hhjiGD80inpA9ojjA4kxMCHacDGiBDEQSPgkU7mHUOBqZpmXRERkfjfNjr19ULq6cEb-7v0-r75edvF9f19uvVl4vzbW0aKnNt28ZQYjvc9z1pwAgwpjWmh4aZDoCSQbSU26HVvSUcc0uF6TrZtKKXHQNgp9Wno--89HsYDPgc9aTm6PY6HlTQTj3teLdTY7hVrCs75qwYfLg3iOHHAimrvUvrPNpDWJIiAkvZESF5Qd__hd6EJfoy3i-KUMYx_kONegLlvA3lX7OaqnNJuGg5ZaRQZ_-gyhlg70zwYF2pPxGQo8DEkFIE-zAjwWqNjTrGRpU0qDU2atW8e7ycB8XvnBSAHoFUWn6E-Gii_7r-BCTA0Js</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1507123400</pqid></control><display><type>article</type><title>High-sensitivity Lens culinaris agglutinin-reactive alpha-fetoprotein assay predicts early detection of hepatocellular carcinoma</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Kumada, Takashi ; Toyoda, Hidenori ; Tada, Toshifumi ; Kiriyama, Seiki ; Tanikawa, Makoto ; Hisanaga, Yasuhiro ; Kanamori, Akira ; Tanaka, Junko ; Kagebayashi, Chiaki ; Satomura, Shinji</creator><creatorcontrib>Kumada, Takashi ; Toyoda, Hidenori ; Tada, Toshifumi ; Kiriyama, Seiki ; Tanikawa, Makoto ; Hisanaga, Yasuhiro ; Kanamori, Akira ; Tanaka, Junko ; Kagebayashi, Chiaki ; Satomura, Shinji</creatorcontrib><description>Background
Prognosis of patients with hepatocellular carcinoma (HCC) remains poor because HCC is frequently diagnosed late. Therefore, regular surveillance has been recommended to detect HCC at the early stage when curative treatments can be applied. HCC biomarkers, including
Lens culinaris
agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3), are widely used for surveillance in Japan. A newly developed immunoassay system measures AFP-L3 % with high sensitivity. This retrospective study aimed to evaluate clinical utility of high-sensitivity AFP-L3 (hs-AFP-L3) as a predictor of early stage HCC in surveillance at a single site.
Methods
Of consecutive 2830 patients in the surveillance between 2000 and 2009, 104 HCC-developed and 104 non-HCC patients were selected by eligibility criteria and propensity score matching. Samples were obtained from the HCC patients who had blood drawn annually for 3 years prior to HCC diagnosis.
Results
In the present study, hs-AFP-L3 was elevated 1 year prior to diagnosis in 34.3 % of patients. The survival rate of patients with the hs-AFP-L3 ≥ 7 % at 1 year prior to diagnosis was significantly lower than that of patients with hs-AFP-L3 < 7 %.
Conclusions
Elevation of hs-AFP-L3 was early predictive of development of HCC even at low AFP levels and in absence of ultrasound findings of suspicious HCC. The hs-AFP-L3 should be added to surveillance programs with US because elevated hs-AFP-L3 may be a trigger to perform enhanced imaging modalities for confirmation of HCC.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-013-0883-1</identifier><identifier>PMID: 24057163</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Abdominal Surgery ; Adult ; Aged ; Aged, 80 and over ; Alpha fetoproteins ; alpha-Fetoproteins - analysis ; Biliary Tract ; Biomarkers, Tumor - blood ; Cancer ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - pathology ; Colorectal Surgery ; Diagnosis ; Early Detection of Cancer ; Female ; Gastroenterology ; Glycoproteins ; Hepatology ; Hepatoma ; Humans ; Japan ; Liver Neoplasms - diagnosis ; Liver Neoplasms - pathology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article—Liver ; Original —Liver, Pancreas, and Biliary Tract ; Pancreas ; Plant Lectins ; Prognosis ; Propensity Score ; Retrospective Studies ; Sensitivity and Specificity ; Surgical Oncology ; Time Factors ; Young Adult</subject><ispartof>Journal of gastroenterology, 2014-03, Vol.49 (3), p.555-563</ispartof><rights>The Author(s) 2013</rights><rights>COPYRIGHT 2014 Springer</rights><rights>Springer Japan 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c627t-f86c21f90bbb16ec5ecc8ccbe63c9ee21d5824fd8abf1404f25c997685b793ee3</citedby><cites>FETCH-LOGICAL-c627t-f86c21f90bbb16ec5ecc8ccbe63c9ee21d5824fd8abf1404f25c997685b793ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-013-0883-1$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-013-0883-1$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24057163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumada, Takashi</creatorcontrib><creatorcontrib>Toyoda, Hidenori</creatorcontrib><creatorcontrib>Tada, Toshifumi</creatorcontrib><creatorcontrib>Kiriyama, Seiki</creatorcontrib><creatorcontrib>Tanikawa, Makoto</creatorcontrib><creatorcontrib>Hisanaga, Yasuhiro</creatorcontrib><creatorcontrib>Kanamori, Akira</creatorcontrib><creatorcontrib>Tanaka, Junko</creatorcontrib><creatorcontrib>Kagebayashi, Chiaki</creatorcontrib><creatorcontrib>Satomura, Shinji</creatorcontrib><title>High-sensitivity Lens culinaris agglutinin-reactive alpha-fetoprotein assay predicts early detection of hepatocellular carcinoma</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background
Prognosis of patients with hepatocellular carcinoma (HCC) remains poor because HCC is frequently diagnosed late. Therefore, regular surveillance has been recommended to detect HCC at the early stage when curative treatments can be applied. HCC biomarkers, including
Lens culinaris
agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3), are widely used for surveillance in Japan. A newly developed immunoassay system measures AFP-L3 % with high sensitivity. This retrospective study aimed to evaluate clinical utility of high-sensitivity AFP-L3 (hs-AFP-L3) as a predictor of early stage HCC in surveillance at a single site.
Methods
Of consecutive 2830 patients in the surveillance between 2000 and 2009, 104 HCC-developed and 104 non-HCC patients were selected by eligibility criteria and propensity score matching. Samples were obtained from the HCC patients who had blood drawn annually for 3 years prior to HCC diagnosis.
Results
In the present study, hs-AFP-L3 was elevated 1 year prior to diagnosis in 34.3 % of patients. The survival rate of patients with the hs-AFP-L3 ≥ 7 % at 1 year prior to diagnosis was significantly lower than that of patients with hs-AFP-L3 < 7 %.
Conclusions
Elevation of hs-AFP-L3 was early predictive of development of HCC even at low AFP levels and in absence of ultrasound findings of suspicious HCC. The hs-AFP-L3 should be added to surveillance programs with US because elevated hs-AFP-L3 may be a trigger to perform enhanced imaging modalities for confirmation of HCC.</description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alpha fetoproteins</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Biliary Tract</subject><subject>Biomarkers, Tumor - blood</subject><subject>Cancer</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Colorectal Surgery</subject><subject>Diagnosis</subject><subject>Early Detection of Cancer</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Glycoproteins</subject><subject>Hepatology</subject><subject>Hepatoma</subject><subject>Humans</subject><subject>Japan</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article—Liver</subject><subject>Original —Liver, Pancreas, and Biliary Tract</subject><subject>Pancreas</subject><subject>Plant Lectins</subject><subject>Prognosis</subject><subject>Propensity Score</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Surgical Oncology</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kk9v1DAQxSMEokvhA3BBlrhwSfHfOLkgVRVtkVbiAmfLccZZV1k72E6lvfWj47CltAjkg62Z33vWjF5VvSX4jGAsPyaMBRM1JqzGbctq8qzaEF4qoqP0ebXBHec1IZKfVK9SusEFxKJ9WZ1QjoUkDdtUd9du3NUJfHLZ3bp8QNvyRmaZnNfRJaTHcVqy887XEbQpECA9zTtdW8hhjiGD80inpA9ojjA4kxMCHacDGiBDEQSPgkU7mHUOBqZpmXRERkfjfNjr19ULq6cEb-7v0-r75edvF9f19uvVl4vzbW0aKnNt28ZQYjvc9z1pwAgwpjWmh4aZDoCSQbSU26HVvSUcc0uF6TrZtKKXHQNgp9Wno--89HsYDPgc9aTm6PY6HlTQTj3teLdTY7hVrCs75qwYfLg3iOHHAimrvUvrPNpDWJIiAkvZESF5Qd__hd6EJfoy3i-KUMYx_kONegLlvA3lX7OaqnNJuGg5ZaRQZ_-gyhlg70zwYF2pPxGQo8DEkFIE-zAjwWqNjTrGRpU0qDU2atW8e7ycB8XvnBSAHoFUWn6E-Gii_7r-BCTA0Js</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Kumada, Takashi</creator><creator>Toyoda, Hidenori</creator><creator>Tada, Toshifumi</creator><creator>Kiriyama, Seiki</creator><creator>Tanikawa, Makoto</creator><creator>Hisanaga, Yasuhiro</creator><creator>Kanamori, Akira</creator><creator>Tanaka, Junko</creator><creator>Kagebayashi, Chiaki</creator><creator>Satomura, Shinji</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140301</creationdate><title>High-sensitivity Lens culinaris agglutinin-reactive alpha-fetoprotein assay predicts early detection of hepatocellular carcinoma</title><author>Kumada, Takashi ; Toyoda, Hidenori ; Tada, Toshifumi ; Kiriyama, Seiki ; Tanikawa, Makoto ; Hisanaga, Yasuhiro ; Kanamori, Akira ; Tanaka, Junko ; Kagebayashi, Chiaki ; Satomura, Shinji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c627t-f86c21f90bbb16ec5ecc8ccbe63c9ee21d5824fd8abf1404f25c997685b793ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alpha fetoproteins</topic><topic>alpha-Fetoproteins - analysis</topic><topic>Biliary Tract</topic><topic>Biomarkers, Tumor - blood</topic><topic>Cancer</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Colorectal Surgery</topic><topic>Diagnosis</topic><topic>Early Detection of Cancer</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Glycoproteins</topic><topic>Hepatology</topic><topic>Hepatoma</topic><topic>Humans</topic><topic>Japan</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - pathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article—Liver</topic><topic>Original —Liver, Pancreas, and Biliary Tract</topic><topic>Pancreas</topic><topic>Plant Lectins</topic><topic>Prognosis</topic><topic>Propensity Score</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Surgical Oncology</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumada, Takashi</creatorcontrib><creatorcontrib>Toyoda, Hidenori</creatorcontrib><creatorcontrib>Tada, Toshifumi</creatorcontrib><creatorcontrib>Kiriyama, Seiki</creatorcontrib><creatorcontrib>Tanikawa, Makoto</creatorcontrib><creatorcontrib>Hisanaga, Yasuhiro</creatorcontrib><creatorcontrib>Kanamori, Akira</creatorcontrib><creatorcontrib>Tanaka, Junko</creatorcontrib><creatorcontrib>Kagebayashi, Chiaki</creatorcontrib><creatorcontrib>Satomura, Shinji</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumada, Takashi</au><au>Toyoda, Hidenori</au><au>Tada, Toshifumi</au><au>Kiriyama, Seiki</au><au>Tanikawa, Makoto</au><au>Hisanaga, Yasuhiro</au><au>Kanamori, Akira</au><au>Tanaka, Junko</au><au>Kagebayashi, Chiaki</au><au>Satomura, Shinji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-sensitivity Lens culinaris agglutinin-reactive alpha-fetoprotein assay predicts early detection of hepatocellular carcinoma</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>49</volume><issue>3</issue><spage>555</spage><epage>563</epage><pages>555-563</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background
Prognosis of patients with hepatocellular carcinoma (HCC) remains poor because HCC is frequently diagnosed late. Therefore, regular surveillance has been recommended to detect HCC at the early stage when curative treatments can be applied. HCC biomarkers, including
Lens culinaris
agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3), are widely used for surveillance in Japan. A newly developed immunoassay system measures AFP-L3 % with high sensitivity. This retrospective study aimed to evaluate clinical utility of high-sensitivity AFP-L3 (hs-AFP-L3) as a predictor of early stage HCC in surveillance at a single site.
Methods
Of consecutive 2830 patients in the surveillance between 2000 and 2009, 104 HCC-developed and 104 non-HCC patients were selected by eligibility criteria and propensity score matching. Samples were obtained from the HCC patients who had blood drawn annually for 3 years prior to HCC diagnosis.
Results
In the present study, hs-AFP-L3 was elevated 1 year prior to diagnosis in 34.3 % of patients. The survival rate of patients with the hs-AFP-L3 ≥ 7 % at 1 year prior to diagnosis was significantly lower than that of patients with hs-AFP-L3 < 7 %.
Conclusions
Elevation of hs-AFP-L3 was early predictive of development of HCC even at low AFP levels and in absence of ultrasound findings of suspicious HCC. The hs-AFP-L3 should be added to surveillance programs with US because elevated hs-AFP-L3 may be a trigger to perform enhanced imaging modalities for confirmation of HCC.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>24057163</pmid><doi>10.1007/s00535-013-0883-1</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of gastroenterology, 2014-03, Vol.49 (3), p.555-563 |
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| subjects | Abdominal Surgery Adult Aged Aged, 80 and over Alpha fetoproteins alpha-Fetoproteins - analysis Biliary Tract Biomarkers, Tumor - blood Cancer Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - pathology Colorectal Surgery Diagnosis Early Detection of Cancer Female Gastroenterology Glycoproteins Hepatology Hepatoma Humans Japan Liver Neoplasms - diagnosis Liver Neoplasms - pathology Male Medicine Medicine & Public Health Middle Aged Original Article—Liver Original —Liver, Pancreas, and Biliary Tract Pancreas Plant Lectins Prognosis Propensity Score Retrospective Studies Sensitivity and Specificity Surgical Oncology Time Factors Young Adult |
| title | High-sensitivity Lens culinaris agglutinin-reactive alpha-fetoprotein assay predicts early detection of hepatocellular carcinoma |
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