Regulatory T Cells Prevent Liver Fibrosis During HIV Type 1 Infection in a Humanized Mouse Model

Human immunodeficiency virus type 1 (HIV-1) disease is associated with aberrant immune activation, and coinfection with hepatitis virus (HCV) exacerbates hepatic inflammation and fibrosis. However, the role of HIV-1 infection or host immune modulation in liver pathogenesis is not clearly defined. He...

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Veröffentlicht in:	The Journal of infectious diseases 2014-04, Vol.209 (7), p.1039-1044
Hauptverfasser:	Nunoya, Jun-ichi, Washburn, Michael L., Kovalev, Grigoriy I., Su, Lishan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Coinfection - complications Coinfection - immunology Disease Models, Animal Fibrosis Fundamental and applied biological sciences. Psychology Gene expression Hepacivirus Hepacivirus - immunology Hepacivirus - isolation & purification Hepatitis C - complications Hepatitis C - immunology Hepatitis C virus Hepatocytes HIV 1 HIV infections HIV Infections - complications HIV Infections - immunology HIV-1 - immunology HIV-1 - isolation & purification HIV/AIDS Human immunodeficiency virus 1 Human viral diseases Humans Infections Infectious diseases Leukocytes Liver Liver Cirrhosis - prevention & control Major and Brief Reports Medical sciences Mice Mice, SCID Microbiology Miscellaneous T lymphocytes T-Lymphocytes, Regulatory - immunology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology
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