Mutagenicity and Genotoxicity of (5′S)‑8,5′-Cyclo-2′-deoxyadenosine in Escherichia coli and Replication of (5′S)‑8,5′-Cyclopurine-2′-deoxynucleosides in Vitro by DNA Polymerase IV, Exo-Free Klenow Fragment, and Dpo4

Reactive oxygen species generate many lesions in DNA, including R and S diastereomers of 8,5′-cyclo-2′-deoxyadenosine (cdA) and 8,5′-cyclo-2′-deoxyguanosine (cdG). Herein, the result of replication of a plasmid containing S-cdA in Escherichia coli is reported. S-cdA was found mutagenic and highly ge...

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Veröffentlicht in:	Chemical research in toxicology 2014-02, Vol.27 (2), p.200-210
Hauptverfasser:	Pednekar, Varsha, Weerasooriya, Savithri, Jasti, Vijay P, Basu, Ashis K
Format:	Artikel
Sprache:	eng
Schlagworte:	Deoxyadenosines - genetics Deoxyguanosine - analogs & derivatives Deoxyguanosine - genetics DNA Polymerase beta - genetics DNA Polymerase I - genetics Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Mutagens Nucleotides - metabolism
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