Physiological and environmental control of yeast prions

Abstract Prions are self-perpetuating protein isoforms that cause fatal and incurable neurodegenerative disease in mammals. Recent evidence indicates that a majority of human proteins involved in amyloid and neural inclusion disorders possess at least some prion properties. In lower eukaryotes, such...

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Veröffentlicht in:	FEMS microbiology reviews 2014-03, Vol.38 (2), p.326-344
Hauptverfasser:	Chernova, Tatiana A., Wilkinson, Keith D., Chernoff, Yury O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - metabolism Adaptation, Physiological - physiology amyloid chaperone cytoskeleton Environment Environmental conditions Environmental control Environmental stress heat shock Heat-Shock Proteins - metabolism Mammals Physiology Prions Prions - metabolism Proteasome Endopeptidase Complex - metabolism Proteins Quality control Rodents Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae - physiology ubiquitin Ubiquitin - metabolism Yeast Yeasts
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