Prenatal exposure to methylmercury and LCPUFA in relation to birth weight
Abstract Background Epidemiologic studies have been inconclusive regarding the impact of coexposure to long chain polyunsaturated fatty acids (LCPUFA) and methylmercury (MeHg) from fish consumption during pregnancy on measures of fetal development. Objectives We evaluated the association between bir...
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| Veröffentlicht in: | Annals of epidemiology 2014-04, Vol.24 (4), p.273-278 |
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| creator | van Wijngaarden, Edwin, PhD Harrington, Donald, MS Kobrosly, Roni, PhD Thurston, Sally W., PhD O'Hara, Todd, DVM, PhD McSorley, Emeir M., PhD Myers, Gary J., MD Watson, Gene E., DDS, PhD Shamlaye, Conrad F., MD, MPH, M. Econ Strain, J.J., PhD Davidson, Philip W., PhD |
| description | Abstract Background Epidemiologic studies have been inconclusive regarding the impact of coexposure to long chain polyunsaturated fatty acids (LCPUFA) and methylmercury (MeHg) from fish consumption during pregnancy on measures of fetal development. Objectives We evaluated the association between birth weight and prenatal maternal LCPUFA status and MeHg exposure in the Republic of Seychelles. Methods We measured LCPUFA in maternal whole blood collected at 28 weeks of gestation and following delivery and MeHg in maternal hair obtained at delivery. There were 230 births with complete data on birth weight and covariates. Multiple linear regression models controlled for infant sex, gestational age, maternal age, smoking during pregnancy, intrapartum weight gain, prepregnancy body mass index, maternal socioeconomic status, parity, gestational diabetes, and alcohol use during pregnancy. Results The average birth weight was 3252 g (range 1654–4450) and the average gestational age was 39 weeks (range 34–41). Prenatal MeHg exposure and maternal LCPUFA status were not associated with birth weight. Infant sex and length of gestation were the only predictors, with male sex and increased gestational age consistently associated with greater birth weight. Conclusions These findings do not support a relationship between prenatal exposure to LCPUFA and/or MeHg from fish consumption and birth weight. |
| doi_str_mv | 10.1016/j.annepidem.2014.01.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3951518</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1047279714000064</els_id><sourcerecordid>1524401481</sourcerecordid><originalsourceid>FETCH-LOGICAL-c629t-ce1a08ff452df2fc07b813c4533a37fc6e867f2fd3a13e12c632b87ec920773b3</originalsourceid><addsrcrecordid>eNqNUk1v1DAUtCpQWxb-AuTIJcEfSZy9VFqtWqi0EpXanp8c56XrJbEX2ynsv8fRlhVw4mRLb9680cwQ8oHRglFWf9oVylrcmw7HglNWFpQVlPIzcskaKXJeNdWr9KelzLlcygvyJoQdpVQ2kp-TC15WvErTS3J759GqqIYMf-5dmDxm0WUjxu1hGNHryR8yZbtss757vFllxmYeBxWNszOuNT5usx9onrbxLXndqyHgu5d3QR5vrh_WX_LN18-369Um1zVfxlwjU7Tp-6Sg63mvqWwbJnRZCaGE7HWNTS3ToBOKCWRc14K3jUS95FRK0YoFuTry7qd2xE6jjV4NsPdmVP4AThn4e2LNFp7cM4hlxSrWJIKPLwTefZ8wRBhN0DgMyqKbArCKl2XyNMlaEHmEau9C8NifzjAKcxCwg1MQMAcBlEEKIm2-_1Plae-38wmwOgIwefVs0EPQBq3GznjUETpn_uPI1T8cejDWaDV8wwOGnZu8TVEAg8CBwv3ch7kOrExVoHUpfgEOqrPj</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1524401481</pqid></control><display><type>article</type><title>Prenatal exposure to methylmercury and LCPUFA in relation to birth weight</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>van Wijngaarden, Edwin, PhD ; Harrington, Donald, MS ; Kobrosly, Roni, PhD ; Thurston, Sally W., PhD ; O'Hara, Todd, DVM, PhD ; McSorley, Emeir M., PhD ; Myers, Gary J., MD ; Watson, Gene E., DDS, PhD ; Shamlaye, Conrad F., MD, MPH, M. Econ ; Strain, J.J., PhD ; Davidson, Philip W., PhD</creator><creatorcontrib>van Wijngaarden, Edwin, PhD ; Harrington, Donald, MS ; Kobrosly, Roni, PhD ; Thurston, Sally W., PhD ; O'Hara, Todd, DVM, PhD ; McSorley, Emeir M., PhD ; Myers, Gary J., MD ; Watson, Gene E., DDS, PhD ; Shamlaye, Conrad F., MD, MPH, M. Econ ; Strain, J.J., PhD ; Davidson, Philip W., PhD</creatorcontrib><description>Abstract Background Epidemiologic studies have been inconclusive regarding the impact of coexposure to long chain polyunsaturated fatty acids (LCPUFA) and methylmercury (MeHg) from fish consumption during pregnancy on measures of fetal development. Objectives We evaluated the association between birth weight and prenatal maternal LCPUFA status and MeHg exposure in the Republic of Seychelles. Methods We measured LCPUFA in maternal whole blood collected at 28 weeks of gestation and following delivery and MeHg in maternal hair obtained at delivery. There were 230 births with complete data on birth weight and covariates. Multiple linear regression models controlled for infant sex, gestational age, maternal age, smoking during pregnancy, intrapartum weight gain, prepregnancy body mass index, maternal socioeconomic status, parity, gestational diabetes, and alcohol use during pregnancy. Results The average birth weight was 3252 g (range 1654–4450) and the average gestational age was 39 weeks (range 34–41). Prenatal MeHg exposure and maternal LCPUFA status were not associated with birth weight. Infant sex and length of gestation were the only predictors, with male sex and increased gestational age consistently associated with greater birth weight. Conclusions These findings do not support a relationship between prenatal exposure to LCPUFA and/or MeHg from fish consumption and birth weight.</description><identifier>ISSN: 1047-2797</identifier><identifier>EISSN: 1873-2585</identifier><identifier>DOI: 10.1016/j.annepidem.2014.01.002</identifier><identifier>PMID: 24525104</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Birth weight ; Birth Weight - drug effects ; Fatty acids ; Fatty Acids, Omega-3 - pharmacology ; Female ; Humans ; Infant, Newborn ; Internal Medicine ; Male ; Maternal Exposure ; Methylmercury compounds ; Methylmercury Compounds - pharmacology ; Nutrition Surveys ; Pregnancy ; Prenatal Exposure Delayed Effects ; Regression Analysis ; Seychelles ; Unsaturated ; Young Adult</subject><ispartof>Annals of epidemiology, 2014-04, Vol.24 (4), p.273-278</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><rights>2014 Elsevier Inc. All rights reserved. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c629t-ce1a08ff452df2fc07b813c4533a37fc6e867f2fd3a13e12c632b87ec920773b3</citedby><cites>FETCH-LOGICAL-c629t-ce1a08ff452df2fc07b813c4533a37fc6e867f2fd3a13e12c632b87ec920773b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1047279714000064$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24525104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Wijngaarden, Edwin, PhD</creatorcontrib><creatorcontrib>Harrington, Donald, MS</creatorcontrib><creatorcontrib>Kobrosly, Roni, PhD</creatorcontrib><creatorcontrib>Thurston, Sally W., PhD</creatorcontrib><creatorcontrib>O'Hara, Todd, DVM, PhD</creatorcontrib><creatorcontrib>McSorley, Emeir M., PhD</creatorcontrib><creatorcontrib>Myers, Gary J., MD</creatorcontrib><creatorcontrib>Watson, Gene E., DDS, PhD</creatorcontrib><creatorcontrib>Shamlaye, Conrad F., MD, MPH, M. Econ</creatorcontrib><creatorcontrib>Strain, J.J., PhD</creatorcontrib><creatorcontrib>Davidson, Philip W., PhD</creatorcontrib><title>Prenatal exposure to methylmercury and LCPUFA in relation to birth weight</title><title>Annals of epidemiology</title><addtitle>Ann Epidemiol</addtitle><description>Abstract Background Epidemiologic studies have been inconclusive regarding the impact of coexposure to long chain polyunsaturated fatty acids (LCPUFA) and methylmercury (MeHg) from fish consumption during pregnancy on measures of fetal development. Objectives We evaluated the association between birth weight and prenatal maternal LCPUFA status and MeHg exposure in the Republic of Seychelles. Methods We measured LCPUFA in maternal whole blood collected at 28 weeks of gestation and following delivery and MeHg in maternal hair obtained at delivery. There were 230 births with complete data on birth weight and covariates. Multiple linear regression models controlled for infant sex, gestational age, maternal age, smoking during pregnancy, intrapartum weight gain, prepregnancy body mass index, maternal socioeconomic status, parity, gestational diabetes, and alcohol use during pregnancy. Results The average birth weight was 3252 g (range 1654–4450) and the average gestational age was 39 weeks (range 34–41). Prenatal MeHg exposure and maternal LCPUFA status were not associated with birth weight. Infant sex and length of gestation were the only predictors, with male sex and increased gestational age consistently associated with greater birth weight. Conclusions These findings do not support a relationship between prenatal exposure to LCPUFA and/or MeHg from fish consumption and birth weight.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Birth weight</subject><subject>Birth Weight - drug effects</subject><subject>Fatty acids</subject><subject>Fatty Acids, Omega-3 - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Maternal Exposure</subject><subject>Methylmercury compounds</subject><subject>Methylmercury Compounds - pharmacology</subject><subject>Nutrition Surveys</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Regression Analysis</subject><subject>Seychelles</subject><subject>Unsaturated</subject><subject>Young Adult</subject><issn>1047-2797</issn><issn>1873-2585</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1v1DAUtCpQWxb-AuTIJcEfSZy9VFqtWqi0EpXanp8c56XrJbEX2ynsv8fRlhVw4mRLb9680cwQ8oHRglFWf9oVylrcmw7HglNWFpQVlPIzcskaKXJeNdWr9KelzLlcygvyJoQdpVQ2kp-TC15WvErTS3J759GqqIYMf-5dmDxm0WUjxu1hGNHryR8yZbtss757vFllxmYeBxWNszOuNT5usx9onrbxLXndqyHgu5d3QR5vrh_WX_LN18-369Um1zVfxlwjU7Tp-6Sg63mvqWwbJnRZCaGE7HWNTS3ToBOKCWRc14K3jUS95FRK0YoFuTry7qd2xE6jjV4NsPdmVP4AThn4e2LNFp7cM4hlxSrWJIKPLwTefZ8wRBhN0DgMyqKbArCKl2XyNMlaEHmEau9C8NifzjAKcxCwg1MQMAcBlEEKIm2-_1Plae-38wmwOgIwefVs0EPQBq3GznjUETpn_uPI1T8cejDWaDV8wwOGnZu8TVEAg8CBwv3ch7kOrExVoHUpfgEOqrPj</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>van Wijngaarden, Edwin, PhD</creator><creator>Harrington, Donald, MS</creator><creator>Kobrosly, Roni, PhD</creator><creator>Thurston, Sally W., PhD</creator><creator>O'Hara, Todd, DVM, PhD</creator><creator>McSorley, Emeir M., PhD</creator><creator>Myers, Gary J., MD</creator><creator>Watson, Gene E., DDS, PhD</creator><creator>Shamlaye, Conrad F., MD, MPH, M. Econ</creator><creator>Strain, J.J., PhD</creator><creator>Davidson, Philip W., PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20140401</creationdate><title>Prenatal exposure to methylmercury and LCPUFA in relation to birth weight</title><author>van Wijngaarden, Edwin, PhD ; Harrington, Donald, MS ; Kobrosly, Roni, PhD ; Thurston, Sally W., PhD ; O'Hara, Todd, DVM, PhD ; McSorley, Emeir M., PhD ; Myers, Gary J., MD ; Watson, Gene E., DDS, PhD ; Shamlaye, Conrad F., MD, MPH, M. Econ ; Strain, J.J., PhD ; Davidson, Philip W., PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c629t-ce1a08ff452df2fc07b813c4533a37fc6e867f2fd3a13e12c632b87ec920773b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Birth weight</topic><topic>Birth Weight - drug effects</topic><topic>Fatty acids</topic><topic>Fatty Acids, Omega-3 - pharmacology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Maternal Exposure</topic><topic>Methylmercury compounds</topic><topic>Methylmercury Compounds - pharmacology</topic><topic>Nutrition Surveys</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Regression Analysis</topic><topic>Seychelles</topic><topic>Unsaturated</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Wijngaarden, Edwin, PhD</creatorcontrib><creatorcontrib>Harrington, Donald, MS</creatorcontrib><creatorcontrib>Kobrosly, Roni, PhD</creatorcontrib><creatorcontrib>Thurston, Sally W., PhD</creatorcontrib><creatorcontrib>O'Hara, Todd, DVM, PhD</creatorcontrib><creatorcontrib>McSorley, Emeir M., PhD</creatorcontrib><creatorcontrib>Myers, Gary J., MD</creatorcontrib><creatorcontrib>Watson, Gene E., DDS, PhD</creatorcontrib><creatorcontrib>Shamlaye, Conrad F., MD, MPH, M. Econ</creatorcontrib><creatorcontrib>Strain, J.J., PhD</creatorcontrib><creatorcontrib>Davidson, Philip W., PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Wijngaarden, Edwin, PhD</au><au>Harrington, Donald, MS</au><au>Kobrosly, Roni, PhD</au><au>Thurston, Sally W., PhD</au><au>O'Hara, Todd, DVM, PhD</au><au>McSorley, Emeir M., PhD</au><au>Myers, Gary J., MD</au><au>Watson, Gene E., DDS, PhD</au><au>Shamlaye, Conrad F., MD, MPH, M. Econ</au><au>Strain, J.J., PhD</au><au>Davidson, Philip W., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal exposure to methylmercury and LCPUFA in relation to birth weight</atitle><jtitle>Annals of epidemiology</jtitle><addtitle>Ann Epidemiol</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>24</volume><issue>4</issue><spage>273</spage><epage>278</epage><pages>273-278</pages><issn>1047-2797</issn><eissn>1873-2585</eissn><abstract>Abstract Background Epidemiologic studies have been inconclusive regarding the impact of coexposure to long chain polyunsaturated fatty acids (LCPUFA) and methylmercury (MeHg) from fish consumption during pregnancy on measures of fetal development. Objectives We evaluated the association between birth weight and prenatal maternal LCPUFA status and MeHg exposure in the Republic of Seychelles. Methods We measured LCPUFA in maternal whole blood collected at 28 weeks of gestation and following delivery and MeHg in maternal hair obtained at delivery. There were 230 births with complete data on birth weight and covariates. Multiple linear regression models controlled for infant sex, gestational age, maternal age, smoking during pregnancy, intrapartum weight gain, prepregnancy body mass index, maternal socioeconomic status, parity, gestational diabetes, and alcohol use during pregnancy. Results The average birth weight was 3252 g (range 1654–4450) and the average gestational age was 39 weeks (range 34–41). Prenatal MeHg exposure and maternal LCPUFA status were not associated with birth weight. Infant sex and length of gestation were the only predictors, with male sex and increased gestational age consistently associated with greater birth weight. Conclusions These findings do not support a relationship between prenatal exposure to LCPUFA and/or MeHg from fish consumption and birth weight.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24525104</pmid><doi>10.1016/j.annepidem.2014.01.002</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Birth weight Birth Weight - drug effects Fatty acids Fatty Acids, Omega-3 - pharmacology Female Humans Infant, Newborn Internal Medicine Male Maternal Exposure Methylmercury compounds Methylmercury Compounds - pharmacology Nutrition Surveys Pregnancy Prenatal Exposure Delayed Effects Regression Analysis Seychelles Unsaturated Young Adult |
| title | Prenatal exposure to methylmercury and LCPUFA in relation to birth weight |
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