Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched peripheral blood stem cell transplantation and mesenchymal stem cells
This is a case report of a 32-year-old man exposed to a total body dose of 14.5 Gy -radiation in a lethal 60Co-source irradiation accident in 2008 in China. Frequent nausea, vomiting and marked neutropenia and lymphopenia were observed from 30 min to 45 h after exposure. HLA-mismatched peripheral bl...
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| Veröffentlicht in: | Journal of radiation research 2014-03, Vol.55 (2), p.205-209 |
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| container_title | Journal of radiation research |
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| creator | Guo, Mei Dong, Zheng Qiao, Jianhui Yu, Changlin Sun, Qiyun Hu, Kaixun Liu, Guangxian Wei, Li Yao, Bo Man, Qiuhong Sun, Xuedong Liu, Zhiqing Song, Zhiwu Yu, Chengze Chen, Ying Luo, Qingliang Liu, Sugang Ai, Hui-Sheng |
| description | This is a case report of a 32-year-old man exposed to a total body dose of 14.5 Gy -radiation in a lethal 60Co-source irradiation accident in 2008 in China. Frequent nausea, vomiting and marked neutropenia and lymphopenia were observed from 30 min to 45 h after exposure. HLA-mismatched peripheral blood stem cell transplantation combined with infusion of mesenchymal stem cells was used at Day 7. Rapid hematopoietic recovery, stable donor engraftment and healing of radioactive skin ulceration were achieved during Days 18-36. The patient finally developed intestinal obstruction and died of multi-organ failure on Day 62, although intestinal obstruction was successfully released by emergency bowel resection. |
| doi_str_mv | 10.1093/jrr/rrt102 |
| format | Article |
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Frequent nausea, vomiting and marked neutropenia and lymphopenia were observed from 30 min to 45 h after exposure. HLA-mismatched peripheral blood stem cell transplantation combined with infusion of mesenchymal stem cells was used at Day 7. Rapid hematopoietic recovery, stable donor engraftment and healing of radioactive skin ulceration were achieved during Days 18-36. The patient finally developed intestinal obstruction and died of multi-organ failure on Day 62, although intestinal obstruction was successfully released by emergency bowel resection.</description><identifier>ISSN: 0449-3060</identifier><identifier>EISSN: 1349-9157</identifier><identifier>DOI: 10.1093/jrr/rrt102</identifier><identifier>PMID: 23979075</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Acute Radiation Syndrome - diagnosis ; Acute Radiation Syndrome - etiology ; Acute Radiation Syndrome - therapy ; Biology ; Cobalt Radioisotopes - poisoning ; Combined Modality Therapy ; Fatal Outcome ; Histocompatibility Testing ; HLA Antigens - immunology ; Humans ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stromal Cells - immunology ; Peripheral Blood Stem Cell Transplantation ; Radioactive Hazard Release</subject><ispartof>Journal of radiation research, 2014-03, Vol.55 (2), p.205-209</ispartof><rights>The Author 2013. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Therapeutic Radiology and Oncology. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2772-c40d8ab03791c72369320e5e99c6208327823931a9bf5638f604aefbf7da23493</citedby><cites>FETCH-LOGICAL-c2772-c40d8ab03791c72369320e5e99c6208327823931a9bf5638f604aefbf7da23493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951066/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951066/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1598,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23979075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Mei</creatorcontrib><creatorcontrib>Dong, Zheng</creatorcontrib><creatorcontrib>Qiao, Jianhui</creatorcontrib><creatorcontrib>Yu, Changlin</creatorcontrib><creatorcontrib>Sun, Qiyun</creatorcontrib><creatorcontrib>Hu, Kaixun</creatorcontrib><creatorcontrib>Liu, Guangxian</creatorcontrib><creatorcontrib>Wei, Li</creatorcontrib><creatorcontrib>Yao, Bo</creatorcontrib><creatorcontrib>Man, Qiuhong</creatorcontrib><creatorcontrib>Sun, Xuedong</creatorcontrib><creatorcontrib>Liu, Zhiqing</creatorcontrib><creatorcontrib>Song, Zhiwu</creatorcontrib><creatorcontrib>Yu, Chengze</creatorcontrib><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Luo, Qingliang</creatorcontrib><creatorcontrib>Liu, Sugang</creatorcontrib><creatorcontrib>Ai, Hui-Sheng</creatorcontrib><title>Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched peripheral blood stem cell transplantation and mesenchymal stem cells</title><title>Journal of radiation research</title><addtitle>J Radiat Res</addtitle><description>This is a case report of a 32-year-old man exposed to a total body dose of 14.5 Gy -radiation in a lethal 60Co-source irradiation accident in 2008 in China. 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The patient finally developed intestinal obstruction and died of multi-organ failure on Day 62, although intestinal obstruction was successfully released by emergency bowel resection.</description><subject>Acute Radiation Syndrome - diagnosis</subject><subject>Acute Radiation Syndrome - etiology</subject><subject>Acute Radiation Syndrome - therapy</subject><subject>Biology</subject><subject>Cobalt Radioisotopes - poisoning</subject><subject>Combined Modality Therapy</subject><subject>Fatal Outcome</subject><subject>Histocompatibility Testing</subject><subject>HLA Antigens - immunology</subject><subject>Humans</subject><subject>Mesenchymal Stem Cell Transplantation</subject><subject>Mesenchymal Stromal Cells - immunology</subject><subject>Peripheral Blood Stem Cell Transplantation</subject><subject>Radioactive Hazard Release</subject><issn>0449-3060</issn><issn>1349-9157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNp9kcGKFDEQhoMo7uzqxQeQXLwI7VYn052JB2EZdFcY8KCem5p0tZ2lkzRJZpZ5PZ_MLK2DXjwlkK--qtTP2Ksa3tWg5fV9jNcx5hrEE7aq5VpXum7UU7aCdblLaOGCXaZ0DyAUNPCcXQiplQbVrNjPr3SkSBzNIROP2FvMNnieTr6PwdF7niNhduQzDwNHPlEecZpOvIVtqFI4REPcxqWS-iIytn-kj9Zk67j1fDtaj_zB5pHf7W4qZ5PDbMYCzxTtPFLEie-nEHqeMjluaJpKW_RpntDnZSD0PXeUyJvx5Ap_JtML9mzAKdHL3-cV-_7p47ftXbX7cvt5e7OrjFBKVGYN_Qb3IJWujRKy1VIANaS1aQVspFCbshZZo94PTSs3QwtrpGE_qB5FWaq8Yh8W73zYO-pN-WQZvJujdRhPXUDb_fvi7dj9CMdO6qaGti2Ct4vAxJBSpOFcW0P3mGRXkuyWJAv8-u9uZ_RPdAV4swDhMP9P9Asyn60a</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Guo, Mei</creator><creator>Dong, Zheng</creator><creator>Qiao, Jianhui</creator><creator>Yu, Changlin</creator><creator>Sun, Qiyun</creator><creator>Hu, Kaixun</creator><creator>Liu, Guangxian</creator><creator>Wei, Li</creator><creator>Yao, Bo</creator><creator>Man, Qiuhong</creator><creator>Sun, Xuedong</creator><creator>Liu, Zhiqing</creator><creator>Song, Zhiwu</creator><creator>Yu, Chengze</creator><creator>Chen, Ying</creator><creator>Luo, Qingliang</creator><creator>Liu, Sugang</creator><creator>Ai, Hui-Sheng</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20140301</creationdate><title>Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched peripheral blood stem cell transplantation and mesenchymal stem cells</title><author>Guo, Mei ; Dong, Zheng ; Qiao, Jianhui ; Yu, Changlin ; Sun, Qiyun ; Hu, Kaixun ; Liu, Guangxian ; Wei, Li ; Yao, Bo ; Man, Qiuhong ; Sun, Xuedong ; Liu, Zhiqing ; Song, Zhiwu ; Yu, Chengze ; Chen, Ying ; Luo, Qingliang ; Liu, Sugang ; Ai, Hui-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2772-c40d8ab03791c72369320e5e99c6208327823931a9bf5638f604aefbf7da23493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acute Radiation Syndrome - diagnosis</topic><topic>Acute Radiation Syndrome - etiology</topic><topic>Acute Radiation Syndrome - therapy</topic><topic>Biology</topic><topic>Cobalt Radioisotopes - poisoning</topic><topic>Combined Modality Therapy</topic><topic>Fatal Outcome</topic><topic>Histocompatibility Testing</topic><topic>HLA Antigens - immunology</topic><topic>Humans</topic><topic>Mesenchymal Stem Cell Transplantation</topic><topic>Mesenchymal Stromal Cells - immunology</topic><topic>Peripheral Blood Stem Cell Transplantation</topic><topic>Radioactive Hazard Release</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Mei</creatorcontrib><creatorcontrib>Dong, Zheng</creatorcontrib><creatorcontrib>Qiao, Jianhui</creatorcontrib><creatorcontrib>Yu, Changlin</creatorcontrib><creatorcontrib>Sun, Qiyun</creatorcontrib><creatorcontrib>Hu, Kaixun</creatorcontrib><creatorcontrib>Liu, Guangxian</creatorcontrib><creatorcontrib>Wei, Li</creatorcontrib><creatorcontrib>Yao, Bo</creatorcontrib><creatorcontrib>Man, Qiuhong</creatorcontrib><creatorcontrib>Sun, Xuedong</creatorcontrib><creatorcontrib>Liu, Zhiqing</creatorcontrib><creatorcontrib>Song, Zhiwu</creatorcontrib><creatorcontrib>Yu, Chengze</creatorcontrib><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Luo, Qingliang</creatorcontrib><creatorcontrib>Liu, Sugang</creatorcontrib><creatorcontrib>Ai, Hui-Sheng</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Mei</au><au>Dong, Zheng</au><au>Qiao, Jianhui</au><au>Yu, Changlin</au><au>Sun, Qiyun</au><au>Hu, Kaixun</au><au>Liu, Guangxian</au><au>Wei, Li</au><au>Yao, Bo</au><au>Man, Qiuhong</au><au>Sun, Xuedong</au><au>Liu, Zhiqing</au><au>Song, Zhiwu</au><au>Yu, Chengze</au><au>Chen, Ying</au><au>Luo, Qingliang</au><au>Liu, Sugang</au><au>Ai, Hui-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched peripheral blood stem cell transplantation and mesenchymal stem cells</atitle><jtitle>Journal of radiation research</jtitle><addtitle>J Radiat Res</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>55</volume><issue>2</issue><spage>205</spage><epage>209</epage><pages>205-209</pages><issn>0449-3060</issn><eissn>1349-9157</eissn><abstract>This is a case report of a 32-year-old man exposed to a total body dose of 14.5 Gy -radiation in a lethal 60Co-source irradiation accident in 2008 in China. Frequent nausea, vomiting and marked neutropenia and lymphopenia were observed from 30 min to 45 h after exposure. HLA-mismatched peripheral blood stem cell transplantation combined with infusion of mesenchymal stem cells was used at Day 7. Rapid hematopoietic recovery, stable donor engraftment and healing of radioactive skin ulceration were achieved during Days 18-36. The patient finally developed intestinal obstruction and died of multi-organ failure on Day 62, although intestinal obstruction was successfully released by emergency bowel resection.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>23979075</pmid><doi>10.1093/jrr/rrt102</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of radiation research, 2014-03, Vol.55 (2), p.205-209 |
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| source | Oxford Journals Open Access Collection; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Acute Radiation Syndrome - diagnosis Acute Radiation Syndrome - etiology Acute Radiation Syndrome - therapy Biology Cobalt Radioisotopes - poisoning Combined Modality Therapy Fatal Outcome Histocompatibility Testing HLA Antigens - immunology Humans Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - immunology Peripheral Blood Stem Cell Transplantation Radioactive Hazard Release |
| title | Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched peripheral blood stem cell transplantation and mesenchymal stem cells |
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