T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow

Trail(+)DX5(-)Eomes(-) natural killer (NK) cells arise in the mouse fetal liver and persist in the adult liver. Their relationships with Trail(-)DX5(+) NK cells remain controversial. We generated a novel Eomes-GFP reporter murine model to address this question. We found that Eomes(-) NK cells are no...

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Veröffentlicht in:	The Journal of experimental medicine 2014-03, Vol.211 (3), p.563-577
Hauptverfasser:	Daussy, Cécile, Faure, Fabrice, Mayol, Katia, Viel, Sébastien, Gasteiger, Georg, Charrier, Emily, Bienvenu, Jacques, Henry, Thomas, Debien, Emilie, Hasan, Uzma A, Marvel, Jacqueline, Yoh, Keigyou, Takahashi, Satoru, Prinz, Immo, de Bernard, Simon, Buffat, Laurent, Walzer, Thierry
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Bone Marrow - metabolism Cell Differentiation - immunology Cell Lineage - immunology DNA Primers - genetics Flow Cytometry Gene Knock-In Techniques Killer Cells, Natural - cytology Killer Cells, Natural - immunology Life Sciences Liver - metabolism Mice Microarray Analysis Models, Animal Real-Time Polymerase Chain Reaction Stem Cell Niche - immunology T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism
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