Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies

Leukemia inhibitory factor (LIF) is a cytokine involved in embryonic and hematopoietic development. To investigate the effects of LIF on the lymphoid system, we generated a line of transgenic mice that expresses diffusible LIF protein specifically in T cells. These mice display two categories of phe...

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Veröffentlicht in:	The EMBO journal 1994-03, Vol.13 (6), p.1375-1385
Hauptverfasser:	Shen, M.M., Skoda, R.C., Cardiff, R.D., Campos‐Torres, J., Leder, P., Ornitz, D.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Biological and medical sciences Blood Bone Marrow Cells Bone Marrow Transplantation CD4-CD8 Ratio Epithelial Cells Epithelium - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Growth Inhibitors - genetics Growth Inhibitors - physiology Hypergammaglobulinemia - etiology Immunobiology Interleukin-6 Leukemia Inhibitory Factor Lymph Nodes - cytology Lymph Nodes - metabolism Lymphokines - genetics Lymphokines - physiology Mice Mice, Transgenic Miscellaneous Phenotype Regulatory factors and their cellular receptors T-Lymphocytes - cytology T-Lymphocytes - immunology Thymus Gland - cytology Thymus Gland - metabolism
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