Mechanisms of cardiac conduction: a history of revisions
Cardiac conduction is the process by which electrical excitation spreads through the heart, triggering individual myocytes to contract in synchrony. Defects in conduction disrupt synchronous activation and are associated with life-threatening arrhythmias in many pathologies. Therefore, it is scarcel...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2014-03, Vol.306 (5), p.H619-H627 |
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| container_end_page | H627 |
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| container_issue | 5 |
| container_start_page | H619 |
| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 306 |
| creator | Veeraraghavan, Rengasayee Gourdie, Robert G Poelzing, Steven |
| description | Cardiac conduction is the process by which electrical excitation spreads through the heart, triggering individual myocytes to contract in synchrony. Defects in conduction disrupt synchronous activation and are associated with life-threatening arrhythmias in many pathologies. Therefore, it is scarcely surprising that this phenomenon continues to be the subject of active scientific inquiry. Here we provide a brief review of how the conceptual understanding of conduction has evolved over the last century and highlight recent, potentially paradigm-shifting developments. |
| doi_str_mv | 10.1152/ajpheart.00760.2013 |
| format | Article |
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Defects in conduction disrupt synchronous activation and are associated with life-threatening arrhythmias in many pathologies. Therefore, it is scarcely surprising that this phenomenon continues to be the subject of active scientific inquiry. 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| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 2014-03, Vol.306 (5), p.H619-H627 |
| issn | 0363-6135 1522-1539 |
| language | eng |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Action Potentials Animals Arrhythmias, Cardiac - etiology Arrhythmias, Cardiac - history Arrhythmias, Cardiac - physiopathology Cardiac arrhythmia Cardiomyocytes Excitation Contraction Coupling Heart Heart Conduction System - physiopathology History, 20th Century History, 21st Century Humans Models, Cardiovascular Myocardial Contraction Pathology Review |
| title | Mechanisms of cardiac conduction: a history of revisions |
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