Chorioamnionitis-induced fetal gut injury is mediated by direct gut exposure of inflammatory mediators or by lung inflammation

Intra-amniotic exposure to proinflammatory agonists causes chorioamnionitis and fetal gut inflammation. Fetal gut inflammation is associated with mucosal injury and impaired gut development. We tested whether this detrimental inflammatory response of the fetal gut results from a direct local (gut de...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2014-03, Vol.306 (5), p.G382-G393
Hauptverfasser:	Wolfs, Tim G A M, Kramer, Boris W, Thuijls, Geertje, Kemp, Matthew W, Saito, Masatoshi, Willems, Monique G M, Senthamarai-Kannan, Paranthaman, Newnham, John P, Jobe, Alan H, Kallapur, Suhas G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amniotic Fluid Animals Cell Differentiation Cell Proliferation Chorioamnionitis - chemically induced Chorioamnionitis - pathology Cytokines - genetics Cytokines - metabolism Digestive system Disease Models, Animal Epithelial Cells - cytology Epithelial Cells - drug effects Female Fetal Diseases - chemically induced Fetal Diseases - etiology Gastrointestinal Diseases - embryology Gastrointestinal Diseases - etiology Gastrointestinal Diseases - pathology Gene Expression Regulation, Developmental - drug effects Ileitis - chemically induced Ileitis - embryology Ileitis - pathology Ileum - embryology Ileum - pathology Inflammation - chemically induced Inflammation - complications Inflammation - pathology Inflammation/Immunity/Mediators Intestinal Mucosa - cytology Leukocytes Lipopolysaccharides - toxicity Lung diseases Pneumonia - chemically induced Pneumonia - complications Pneumonia - pathology Pregnancy Proteins Random Allocation Ribonucleic acid RNA Sheep T-Lymphocytes, Regulatory TNF inhibitors Toll-Like Receptors
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