Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662

AMP-activated protein kinase (AMPK) is a key cellular energy sensor and regulator of metabolic homeostasis. Activation of AMPK provides beneficial outcomes in fighting against metabolic disorders such as insulin resistance and type 2 diabetes. Currently, there is no allosteric AMPK activator availab...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2014-03, Vol.306 (6), p.E688-E696
Hauptverfasser:	Ducommun, Serge, Ford, Rebecca J, Bultot, Laurent, Deak, Maria, Bertrand, Luc, Kemp, Bruce E, Steinberg, Gregory R, Sakamoto, Kei
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation - drug effects Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - pharmacology AMP-Activated Protein Kinases - chemistry AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Cell Line Cells, Cultured Enzyme Activators - pharmacology Glucose - metabolism Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - metabolism Homeostasis Hypoglycemic Agents - pharmacology Kinases Lipogenesis - drug effects Metabolic disorders Metabolism Mice Mice, Inbred C57BL Mice, Knockout Myoblasts - drug effects Myoblasts - metabolism Phosphorylation - drug effects Protein Processing, Post-Translational - drug effects Protein Subunits - agonists Protein Subunits - genetics Protein Subunits - metabolism Pyrones - pharmacology Recombinant Proteins - chemistry Recombinant Proteins - metabolism Ribonucleotides - pharmacology Signal Transduction - drug effects Thiophenes - pharmacology
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