Inhibitory effect of chemical constituents from Artemisia scoparia Waldst. et Kit. on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells
We investigated the anti-obesity effect of the aerial part of Artemisia scoparia Waldst. et Kit. (Compositae). An 80 % aqueous EtOH extract of the aerial part inhibited triglyceride (TG) accumulation and the nitric oxide (NO) production activity. A new chromane derivative was isolated from the aeria...
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| Veröffentlicht in: | Journal of natural medicines 2014-04, Vol.68 (2), p.414-420 |
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| creator | Yahagi, Tadahiro Yakura, Naoyuki Matsuzaki, Keiichi Kitanaka, Susumu |
| description | We investigated the anti-obesity effect of the aerial part of Artemisia scoparia Waldst. et Kit. (Compositae). An 80 % aqueous EtOH extract of the aerial part inhibited triglyceride (TG) accumulation and the nitric oxide (NO) production activity. A new chromane derivative was isolated from the aerial part of A. scoparia Waldst. et Kit. along with 18 known compounds. The structure of the new chromane, scopariachromane (1), was elucidated by spectroscopic analyses. The inhibitory effects of the compounds on TG accumulation activity were examined. Among these, cirsiliol (11) inhibited TG accumulation in 3T3-L1 preadipocytes. Jaceosidin (12) inhibited NO production in a murine macrophage-like cell line (RAW 264.7). These results indicate that the 80 % aqueous EtOH extract and compounds isolated from the aerial part of A. scoparia Waldst. et Kit. may improve obesity-related insulin resistance. |
| doi_str_mv | 10.1007/s11418-013-0799-3 |
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(Compositae). An 80 % aqueous EtOH extract of the aerial part inhibited triglyceride (TG) accumulation and the nitric oxide (NO) production activity. A new chromane derivative was isolated from the aerial part of A. scoparia Waldst. et Kit. along with 18 known compounds. The structure of the new chromane, scopariachromane (1), was elucidated by spectroscopic analyses. The inhibitory effects of the compounds on TG accumulation activity were examined. Among these, cirsiliol (11) inhibited TG accumulation in 3T3-L1 preadipocytes. Jaceosidin (12) inhibited NO production in a murine macrophage-like cell line (RAW 264.7). These results indicate that the 80 % aqueous EtOH extract and compounds isolated from the aerial part of A. scoparia Waldst. et Kit. may improve obesity-related insulin resistance.</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-013-0799-3</identifier><identifier>PMID: 24142543</identifier><language>eng</language><publisher>Tokyo: Springer-Verlag</publisher><subject>3T3-L1 Cells ; Animals ; Anti-Obesity Agents - chemistry ; Anti-Obesity Agents - pharmacology ; Artemisia - chemistry ; Artemisia scoparia ; Biomedical and Life Sciences ; Biomedicine ; Cell Line ; chemical composition ; Chromans - chemistry ; Chromans - pharmacology ; Complementary & Alternative Medicine ; ethanol ; insulin resistance ; jaceosidin ; Macrophages - drug effects ; Macrophages - metabolism ; Medicinal Chemistry ; Mice ; nitric oxide ; Nitric Oxide - biosynthesis ; Pharmacology/Toxicology ; Pharmacy ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Sciences ; spectroscopy ; triacylglycerols ; Triglycerides - metabolism</subject><ispartof>Journal of natural medicines, 2014-04, Vol.68 (2), p.414-420</ispartof><rights>The Author(s) 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-23f08e3b648e8709ef715695b39bbeab0b695ec9cd621ec53eabde495efe03443</citedby><cites>FETCH-LOGICAL-c583t-23f08e3b648e8709ef715695b39bbeab0b695ec9cd621ec53eabde495efe03443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11418-013-0799-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11418-013-0799-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24142543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yahagi, Tadahiro</creatorcontrib><creatorcontrib>Yakura, Naoyuki</creatorcontrib><creatorcontrib>Matsuzaki, Keiichi</creatorcontrib><creatorcontrib>Kitanaka, Susumu</creatorcontrib><title>Inhibitory effect of chemical constituents from Artemisia scoparia Waldst. et Kit. on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>We investigated the anti-obesity effect of the aerial part of Artemisia scoparia Waldst. et Kit. (Compositae). An 80 % aqueous EtOH extract of the aerial part inhibited triglyceride (TG) accumulation and the nitric oxide (NO) production activity. A new chromane derivative was isolated from the aerial part of A. scoparia Waldst. et Kit. along with 18 known compounds. The structure of the new chromane, scopariachromane (1), was elucidated by spectroscopic analyses. The inhibitory effects of the compounds on TG accumulation activity were examined. Among these, cirsiliol (11) inhibited TG accumulation in 3T3-L1 preadipocytes. Jaceosidin (12) inhibited NO production in a murine macrophage-like cell line (RAW 264.7). These results indicate that the 80 % aqueous EtOH extract and compounds isolated from the aerial part of A. scoparia Waldst. et Kit. may improve obesity-related insulin resistance.</description><subject>3T3-L1 Cells</subject><subject>Animals</subject><subject>Anti-Obesity Agents - chemistry</subject><subject>Anti-Obesity Agents - pharmacology</subject><subject>Artemisia - chemistry</subject><subject>Artemisia scoparia</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Line</subject><subject>chemical composition</subject><subject>Chromans - chemistry</subject><subject>Chromans - pharmacology</subject><subject>Complementary & Alternative Medicine</subject><subject>ethanol</subject><subject>insulin resistance</subject><subject>jaceosidin</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Medicinal Chemistry</subject><subject>Mice</subject><subject>nitric oxide</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Sciences</subject><subject>spectroscopy</subject><subject>triacylglycerols</subject><subject>Triglycerides - metabolism</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAQjRCIlsIP4AI-csky9jjZ5IK0qvioqIQErXq0HGey6yprL7ZTsX-K34ijtBVcOM143ps3nnlF8ZrDigOs30fOJW9K4FjCum1LfFKc8qbmJYgWn-YcJZQoJZ4UL2K8BZACkT8vToTkUlQST4vfF25nO5t8ODIaBjKJ-YGZHe2t0SMz3sVk00QuRTYEv2ebkDIWrWbR-IMOObnRYx_TilFiX22O3rEU7HY8Ggq2J6aNmfbTqJPNiHUMr7C85MzQOEamXc-czXzD_K-ZfQi-n8wD9_vmholartYL_WXxbNBjpFf38ay4_vTx6vxLefnt88X55rI0VYOpFDhAQ9jVsqFmDS0Na17VbdVh23WkO-jyg0xr-lpwMhXmWk8y1waC-WBnxYdF9zB1e-pN3j_oUR2C3etwVF5b9S_i7E5t_Z3CVjYVhyzw7l4g-J8TxaTy0eYVtCM_RcUrqCWgwHkWX6gm-BgDDY9jOKjZZ7X4rLLPavZZYe558_f_HjsejM0EsRBihtyWgrr1U3D5Zv9Vfbs0DdorvQ02qusfArgE4C0XDeAfAB2_eg</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Yahagi, Tadahiro</creator><creator>Yakura, Naoyuki</creator><creator>Matsuzaki, Keiichi</creator><creator>Kitanaka, Susumu</creator><general>Springer-Verlag</general><general>Springer Japan</general><scope>FBQ</scope><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140401</creationdate><title>Inhibitory effect of chemical constituents from Artemisia scoparia Waldst. et Kit. on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells</title><author>Yahagi, Tadahiro ; Yakura, Naoyuki ; Matsuzaki, Keiichi ; Kitanaka, Susumu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-23f08e3b648e8709ef715695b39bbeab0b695ec9cd621ec53eabde495efe03443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>3T3-L1 Cells</topic><topic>Animals</topic><topic>Anti-Obesity Agents - chemistry</topic><topic>Anti-Obesity Agents - pharmacology</topic><topic>Artemisia - chemistry</topic><topic>Artemisia scoparia</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Line</topic><topic>chemical composition</topic><topic>Chromans - chemistry</topic><topic>Chromans - pharmacology</topic><topic>Complementary & Alternative Medicine</topic><topic>ethanol</topic><topic>insulin resistance</topic><topic>jaceosidin</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - metabolism</topic><topic>Medicinal Chemistry</topic><topic>Mice</topic><topic>nitric oxide</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Sciences</topic><topic>spectroscopy</topic><topic>triacylglycerols</topic><topic>Triglycerides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yahagi, Tadahiro</creatorcontrib><creatorcontrib>Yakura, Naoyuki</creatorcontrib><creatorcontrib>Matsuzaki, Keiichi</creatorcontrib><creatorcontrib>Kitanaka, Susumu</creatorcontrib><collection>AGRIS</collection><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yahagi, Tadahiro</au><au>Yakura, Naoyuki</au><au>Matsuzaki, Keiichi</au><au>Kitanaka, Susumu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory effect of chemical constituents from Artemisia scoparia Waldst. et Kit. on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>68</volume><issue>2</issue><spage>414</spage><epage>420</epage><pages>414-420</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>We investigated the anti-obesity effect of the aerial part of Artemisia scoparia Waldst. et Kit. (Compositae). An 80 % aqueous EtOH extract of the aerial part inhibited triglyceride (TG) accumulation and the nitric oxide (NO) production activity. A new chromane derivative was isolated from the aerial part of A. scoparia Waldst. et Kit. along with 18 known compounds. The structure of the new chromane, scopariachromane (1), was elucidated by spectroscopic analyses. The inhibitory effects of the compounds on TG accumulation activity were examined. Among these, cirsiliol (11) inhibited TG accumulation in 3T3-L1 preadipocytes. Jaceosidin (12) inhibited NO production in a murine macrophage-like cell line (RAW 264.7). These results indicate that the 80 % aqueous EtOH extract and compounds isolated from the aerial part of A. scoparia Waldst. et Kit. may improve obesity-related insulin resistance.</abstract><cop>Tokyo</cop><pub>Springer-Verlag</pub><pmid>24142543</pmid><doi>10.1007/s11418-013-0799-3</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 3T3-L1 Cells Animals Anti-Obesity Agents - chemistry Anti-Obesity Agents - pharmacology Artemisia - chemistry Artemisia scoparia Biomedical and Life Sciences Biomedicine Cell Line chemical composition Chromans - chemistry Chromans - pharmacology Complementary & Alternative Medicine ethanol insulin resistance jaceosidin Macrophages - drug effects Macrophages - metabolism Medicinal Chemistry Mice nitric oxide Nitric Oxide - biosynthesis Pharmacology/Toxicology Pharmacy Plant Extracts - chemistry Plant Extracts - pharmacology Plant Sciences spectroscopy triacylglycerols Triglycerides - metabolism |
| title | Inhibitory effect of chemical constituents from Artemisia scoparia Waldst. et Kit. on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells |
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