Domain-specific effects of prenatal exposure to PCBs, mercury, and lead on infant cognition: results from the Environmental Contaminants and Child Development Study in Nunavik
Polychlorinated biphenyls (PCBs), methylmercury (MeHg), and lead (Pb) are environmental contaminants known for their adverse effects on cognitive development. In this study we examined the effects of prenatal exposure to PCBs, MeHg, and Pb on cognitive development in a sample of Inuit infants from A...
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| Veröffentlicht in: | Environmental health perspectives 2014-03, Vol.122 (3), p.310-316 |
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| creator | Boucher, Olivier Muckle, Gina Jacobson, Joseph L Carter, R Colin Kaplan-Estrin, Melissa Ayotte, Pierre Dewailly, Éric Jacobson, Sandra W |
| description | Polychlorinated biphenyls (PCBs), methylmercury (MeHg), and lead (Pb) are environmental contaminants known for their adverse effects on cognitive development.
In this study we examined the effects of prenatal exposure to PCBs, MeHg, and Pb on cognitive development in a sample of Inuit infants from Arctic Québec.
Mothers were recruited at local prenatal clinics. PCBs, mercury (Hg), Pb, and two seafood nutrients-docosahexaenoic acid (DHA) and selenium (Se)-were measured in umbilical cord blood. Infants (n = 94) were assessed at 6.5 and 11 months of age on the Fagan Test of Infant Intelligence (FTII), A-not-B test, and Bayley Scales of Infant Development-2nd Edition (BSID-II).
Multiple regression analyses revealed that higher prenatal PCB exposure was associated with decreased FTII novelty preference, indicating impaired visual recognition memory. Prenatal Hg was associated with poorer performance on A-not-B, which depends on working memory and is believed to be a precursor of executive function. Prenatal Pb was related to longer FTII fixation durations, indicating slower speed of information processing.
PCBs, MeHg, and Pb each showed specific and distinct patterns of adverse associations with the outcomes measured during infancy. By contrast, none of these exposures was associated with performance on the BSID-II, a global developmental measure. The more focused, narrow band measures of cognitive function that appeared to be sensitive to these exposures also provide early indications of long-term impairment in specific domains that would otherwise not likely be evident until school age.
Boucher O, Muckle G, Jacobson JL, Carter RC, Kaplan-Estrin M, Ayotte P, Dewailly É, Jacobson SW. 2014. Domain-specific effects of prenatal exposure to PCBs, mercury, and lead on infant cognition: results from the Environmental Contaminants and Child Development Study in Nunavik. Environ Health Perspect 122:310-316; http://dx.doi.org/10.1289/ehp.1206323. |
| doi_str_mv | 10.1289/ehp.1206323 |
| format | Article |
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In this study we examined the effects of prenatal exposure to PCBs, MeHg, and Pb on cognitive development in a sample of Inuit infants from Arctic Québec.
Mothers were recruited at local prenatal clinics. PCBs, mercury (Hg), Pb, and two seafood nutrients-docosahexaenoic acid (DHA) and selenium (Se)-were measured in umbilical cord blood. Infants (n = 94) were assessed at 6.5 and 11 months of age on the Fagan Test of Infant Intelligence (FTII), A-not-B test, and Bayley Scales of Infant Development-2nd Edition (BSID-II).
Multiple regression analyses revealed that higher prenatal PCB exposure was associated with decreased FTII novelty preference, indicating impaired visual recognition memory. Prenatal Hg was associated with poorer performance on A-not-B, which depends on working memory and is believed to be a precursor of executive function. Prenatal Pb was related to longer FTII fixation durations, indicating slower speed of information processing.
PCBs, MeHg, and Pb each showed specific and distinct patterns of adverse associations with the outcomes measured during infancy. By contrast, none of these exposures was associated with performance on the BSID-II, a global developmental measure. The more focused, narrow band measures of cognitive function that appeared to be sensitive to these exposures also provide early indications of long-term impairment in specific domains that would otherwise not likely be evident until school age.
Boucher O, Muckle G, Jacobson JL, Carter RC, Kaplan-Estrin M, Ayotte P, Dewailly É, Jacobson SW. 2014. Domain-specific effects of prenatal exposure to PCBs, mercury, and lead on infant cognition: results from the Environmental Contaminants and Child Development Study in Nunavik. Environ Health Perspect 122:310-316; http://dx.doi.org/10.1289/ehp.1206323.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.1206323</identifier><identifier>PMID: 24441767</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences</publisher><subject>Adolescent ; Adult ; Age ; Alcohol ; Babies ; Bioaccumulation ; Child ; Child development ; Child Development - drug effects ; Children & youth ; Children's Health ; Cocaine ; Cognition ; Cognition & reasoning ; Cognition - drug effects ; Cognition in infants ; Cognitive ability ; Contaminants ; Development ; Environmental aspects ; Environmental Exposure ; Environmental Monitoring ; Environmental Pollutants - blood ; Environmental Pollutants - toxicity ; Exposure ; Female ; Fetus ; Fish ; Growth ; Health ; Health aspects ; Humans ; Infant ; Infants ; Inuit ; Inuits ; Lead ; Lead (metal) ; Lead - blood ; Lead - toxicity ; Male ; Mammals ; Memory ; Mercury ; Mercury (metal) ; Methylmercury ; Methylmercury Compounds - blood ; Methylmercury Compounds - toxicity ; Neurotoxicity ; PCB ; Physiological aspects ; Polychlorinated biphenyls ; Polychlorinated Biphenyls - blood ; Polychlorinated Biphenyls - toxicity ; Pregnancy ; Pregnant women ; Prenatal exposure ; Prenatal Exposure Delayed Effects - epidemiology ; Public health ; Quebec - epidemiology ; Seafood ; Selenium ; Studies ; Young Adult</subject><ispartof>Environmental health perspectives, 2014-03, Vol.122 (3), p.310-316</ispartof><rights>COPYRIGHT 2014 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences Mar 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c745t-8e09cd7e2934d75e8efec8c52bcdfb597c2c33e2d81f8cfbd46fed778a4d77b33</citedby><cites>FETCH-LOGICAL-c745t-8e09cd7e2934d75e8efec8c52bcdfb597c2c33e2d81f8cfbd46fed778a4d77b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948023/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948023/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24441767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boucher, Olivier</creatorcontrib><creatorcontrib>Muckle, Gina</creatorcontrib><creatorcontrib>Jacobson, Joseph L</creatorcontrib><creatorcontrib>Carter, R Colin</creatorcontrib><creatorcontrib>Kaplan-Estrin, Melissa</creatorcontrib><creatorcontrib>Ayotte, Pierre</creatorcontrib><creatorcontrib>Dewailly, Éric</creatorcontrib><creatorcontrib>Jacobson, Sandra W</creatorcontrib><title>Domain-specific effects of prenatal exposure to PCBs, mercury, and lead on infant cognition: results from the Environmental Contaminants and Child Development Study in Nunavik</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Polychlorinated biphenyls (PCBs), methylmercury (MeHg), and lead (Pb) are environmental contaminants known for their adverse effects on cognitive development.
In this study we examined the effects of prenatal exposure to PCBs, MeHg, and Pb on cognitive development in a sample of Inuit infants from Arctic Québec.
Mothers were recruited at local prenatal clinics. PCBs, mercury (Hg), Pb, and two seafood nutrients-docosahexaenoic acid (DHA) and selenium (Se)-were measured in umbilical cord blood. Infants (n = 94) were assessed at 6.5 and 11 months of age on the Fagan Test of Infant Intelligence (FTII), A-not-B test, and Bayley Scales of Infant Development-2nd Edition (BSID-II).
Multiple regression analyses revealed that higher prenatal PCB exposure was associated with decreased FTII novelty preference, indicating impaired visual recognition memory. Prenatal Hg was associated with poorer performance on A-not-B, which depends on working memory and is believed to be a precursor of executive function. Prenatal Pb was related to longer FTII fixation durations, indicating slower speed of information processing.
PCBs, MeHg, and Pb each showed specific and distinct patterns of adverse associations with the outcomes measured during infancy. By contrast, none of these exposures was associated with performance on the BSID-II, a global developmental measure. The more focused, narrow band measures of cognitive function that appeared to be sensitive to these exposures also provide early indications of long-term impairment in specific domains that would otherwise not likely be evident until school age.
Boucher O, Muckle G, Jacobson JL, Carter RC, Kaplan-Estrin M, Ayotte P, Dewailly É, Jacobson SW. 2014. Domain-specific effects of prenatal exposure to PCBs, mercury, and lead on infant cognition: results from the Environmental Contaminants and Child Development Study in Nunavik. Environ Health Perspect 122:310-316; http://dx.doi.org/10.1289/ehp.1206323.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Alcohol</subject><subject>Babies</subject><subject>Bioaccumulation</subject><subject>Child</subject><subject>Child development</subject><subject>Child Development - drug effects</subject><subject>Children & youth</subject><subject>Children's Health</subject><subject>Cocaine</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognition - drug effects</subject><subject>Cognition in infants</subject><subject>Cognitive ability</subject><subject>Contaminants</subject><subject>Development</subject><subject>Environmental aspects</subject><subject>Environmental Exposure</subject><subject>Environmental Monitoring</subject><subject>Environmental Pollutants - blood</subject><subject>Environmental Pollutants - toxicity</subject><subject>Exposure</subject><subject>Female</subject><subject>Fetus</subject><subject>Fish</subject><subject>Growth</subject><subject>Health</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Inuit</subject><subject>Inuits</subject><subject>Lead</subject><subject>Lead (metal)</subject><subject>Lead - blood</subject><subject>Lead - toxicity</subject><subject>Male</subject><subject>Mammals</subject><subject>Memory</subject><subject>Mercury</subject><subject>Mercury (metal)</subject><subject>Methylmercury</subject><subject>Methylmercury Compounds - blood</subject><subject>Methylmercury Compounds - toxicity</subject><subject>Neurotoxicity</subject><subject>PCB</subject><subject>Physiological aspects</subject><subject>Polychlorinated biphenyls</subject><subject>Polychlorinated Biphenyls - blood</subject><subject>Polychlorinated Biphenyls - toxicity</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Prenatal exposure</subject><subject>Prenatal Exposure Delayed Effects - epidemiology</subject><subject>Public health</subject><subject>Quebec - epidemiology</subject><subject>Seafood</subject><subject>Selenium</subject><subject>Studies</subject><subject>Young 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(Full Participant titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boucher, Olivier</au><au>Muckle, Gina</au><au>Jacobson, Joseph L</au><au>Carter, R Colin</au><au>Kaplan-Estrin, Melissa</au><au>Ayotte, Pierre</au><au>Dewailly, Éric</au><au>Jacobson, Sandra W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Domain-specific effects of prenatal exposure to PCBs, mercury, and lead on infant cognition: results from the Environmental Contaminants and Child Development Study in Nunavik</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>122</volume><issue>3</issue><spage>310</spage><epage>316</epage><pages>310-316</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>Polychlorinated biphenyls (PCBs), methylmercury (MeHg), and lead (Pb) are environmental contaminants known for their adverse effects on cognitive development.
In this study we examined the effects of prenatal exposure to PCBs, MeHg, and Pb on cognitive development in a sample of Inuit infants from Arctic Québec.
Mothers were recruited at local prenatal clinics. PCBs, mercury (Hg), Pb, and two seafood nutrients-docosahexaenoic acid (DHA) and selenium (Se)-were measured in umbilical cord blood. Infants (n = 94) were assessed at 6.5 and 11 months of age on the Fagan Test of Infant Intelligence (FTII), A-not-B test, and Bayley Scales of Infant Development-2nd Edition (BSID-II).
Multiple regression analyses revealed that higher prenatal PCB exposure was associated with decreased FTII novelty preference, indicating impaired visual recognition memory. Prenatal Hg was associated with poorer performance on A-not-B, which depends on working memory and is believed to be a precursor of executive function. Prenatal Pb was related to longer FTII fixation durations, indicating slower speed of information processing.
PCBs, MeHg, and Pb each showed specific and distinct patterns of adverse associations with the outcomes measured during infancy. By contrast, none of these exposures was associated with performance on the BSID-II, a global developmental measure. The more focused, narrow band measures of cognitive function that appeared to be sensitive to these exposures also provide early indications of long-term impairment in specific domains that would otherwise not likely be evident until school age.
Boucher O, Muckle G, Jacobson JL, Carter RC, Kaplan-Estrin M, Ayotte P, Dewailly É, Jacobson SW. 2014. Domain-specific effects of prenatal exposure to PCBs, mercury, and lead on infant cognition: results from the Environmental Contaminants and Child Development Study in Nunavik. Environ Health Perspect 122:310-316; http://dx.doi.org/10.1289/ehp.1206323.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences</pub><pmid>24441767</pmid><doi>10.1289/ehp.1206323</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6765 |
| ispartof | Environmental health perspectives, 2014-03, Vol.122 (3), p.310-316 |
| issn | 0091-6765 1552-9924 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3948023 |
| source | Jstor Complete Legacy; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Adolescent Adult Age Alcohol Babies Bioaccumulation Child Child development Child Development - drug effects Children & youth Children's Health Cocaine Cognition Cognition & reasoning Cognition - drug effects Cognition in infants Cognitive ability Contaminants Development Environmental aspects Environmental Exposure Environmental Monitoring Environmental Pollutants - blood Environmental Pollutants - toxicity Exposure Female Fetus Fish Growth Health Health aspects Humans Infant Infants Inuit Inuits Lead Lead (metal) Lead - blood Lead - toxicity Male Mammals Memory Mercury Mercury (metal) Methylmercury Methylmercury Compounds - blood Methylmercury Compounds - toxicity Neurotoxicity PCB Physiological aspects Polychlorinated biphenyls Polychlorinated Biphenyls - blood Polychlorinated Biphenyls - toxicity Pregnancy Pregnant women Prenatal exposure Prenatal Exposure Delayed Effects - epidemiology Public health Quebec - epidemiology Seafood Selenium Studies Young Adult |
| title | Domain-specific effects of prenatal exposure to PCBs, mercury, and lead on infant cognition: results from the Environmental Contaminants and Child Development Study in Nunavik |
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