NOP receptor mediates anti-analgesia induced by agonist–antagonist opioids

Highlights • In male rats, κ-opioids produce analgesia, followed by anti-analgesia. • Low-dose naloxone blocked anti-analgesia but not analgesia. • Nociceptin/orphanin FQ (NOP) antagonists also blocked anti-analgesia. • Selective kappa antagonist nor-BNI did not block nalbuphine-induced anti-analges...

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Veröffentlicht in:	Neuroscience 2014-01, Vol.257, p.139-148
Hauptverfasser:	Gear, R.W, Bogen, O, Ferrari, L.F, Green, P.G, Levine, J.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacology Analysis of Variance Animals Benzeneacetamides Biological and medical sciences Dose-Response Relationship, Drug Drug Interactions Female Fundamental and applied biological sciences. Psychology Male Nalbuphine - pharmacology Naloxone - pharmacology Narcotic Antagonists - pharmacology Neurology Nociceptin Opioid Peptides - metabolism Pain Measurement - drug effects Pain Threshold - drug effects Protein Binding - drug effects Pyrrolidines Rats Rats, Sprague-Dawley Sex Differentiation Vertebrates: nervous system and sense organs
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