Protein-Protein Interaction Detection: Methods and Analysis
Protein-protein interaction plays key role in predicting the protein function of target protein and drug ability of molecules. The majority of genes and proteins realize resulting phenotype functions as a set of interactions. The in vitro and in vivo methods like affinity purification, Y2H (yeast 2...
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Veröffentlicht in: | International Journal of Proteomics 2014-01, Vol.2014 (2014), p.35-46 |
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container_title | International Journal of Proteomics |
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creator | Rao, V. Srinivasa Srinivas, K. Sujini, G. N. Kumar, G. N. Sunand |
description | Protein-protein interaction plays key role in predicting the protein function of target protein and drug ability of molecules. The majority of genes and proteins realize resulting phenotype functions as a set of interactions. The in vitro and in vivo methods like affinity purification, Y2H (yeast 2 hybrid), TAP (tandem affinity purification), and so forth have their own limitations like cost, time, and so forth, and the resultant data sets are noisy and have more false positives to annotate the function of drug molecules. Thus, in silico methods which include sequence-based approaches, structure-based approaches, chromosome proximity, gene fusion, in silico 2 hybrid, phylogenetic tree, phylogenetic profile, and gene expression-based approaches were developed. Elucidation of protein interaction networks also contributes greatly to the analysis of signal transduction pathways. Recent developments have also led to the construction of networks having all the protein-protein interactions using computational methods for signaling pathways and protein complex identification in specific diseases. |
doi_str_mv | 10.1155/2014/147648 |
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Srinivasa ; Srinivas, K. ; Sujini, G. N. ; Kumar, G. N. Sunand</creator><contributor>Zhou, Yaoqi</contributor><creatorcontrib>Rao, V. Srinivasa ; Srinivas, K. ; Sujini, G. N. ; Kumar, G. N. Sunand ; Zhou, Yaoqi</creatorcontrib><description>Protein-protein interaction plays key role in predicting the protein function of target protein and drug ability of molecules. The majority of genes and proteins realize resulting phenotype functions as a set of interactions. The in vitro and in vivo methods like affinity purification, Y2H (yeast 2 hybrid), TAP (tandem affinity purification), and so forth have their own limitations like cost, time, and so forth, and the resultant data sets are noisy and have more false positives to annotate the function of drug molecules. 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Recent developments have also led to the construction of networks having all the protein-protein interactions using computational methods for signaling pathways and protein complex identification in specific diseases.</description><subject>Cell nuclei</subject><subject>Cellular signal transduction</subject><subject>Chromosomes</subject><subject>Gene expression</subject><subject>Gene fusion</subject><subject>Methods</subject><subject>Protein-protein interactions</subject><subject>Proteins</subject><subject>Review</subject><subject>الكروموسومات</subject><subject>علم الوراثة</subject><issn>2090-2166</issn><issn>2090-2174</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><recordid>eNqFkt9LHDEQx0NpqWJ96rNloW-W1fyYbDYVhMPW1mKpD_U5xGTWi9wlkqwt_vfNuXpWEEwCk8x88mXCN4S8Z3SPMSn3OWWwz0B10L8im5xq2nKm4PV633UbZLuUK1oHaJAC3pINDp0WwNUmOTjLacQQ2_vYnMQRs3VjSLH5giPe7T43P3GcJ18aG30zi3ZxW0J5R94MdlFw-z5ukfPjr7-Pvrenv76dHM1OWwu96FscOCL42pbyXErJNHghPO9Ef0GVlpaKQYMYHFLHqEKrLAivuUel6nJiixxOutc3F0v0DuOY7cJc57C0-dYkG8zTSgxzc5n-GKFB9UpWgY-TwKVdoAlxSBVzy1CcmUFth3GAFbX3DFWnx2VwKeIQav7JhU_TBZdTKRmHdUuMmpU7ZuWOmdyp9If_X7FmH7yowO4EzEP09m94QW1ngrEiONg1DKClYLX-Y6rbkMMYzFW6ydW2Ys6qimSMy_od7hQZN4-pKfd4ENJAJ_4BrzqypA</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Rao, V. 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subjects | Cell nuclei Cellular signal transduction Chromosomes Gene expression Gene fusion Methods Protein-protein interactions Proteins Review الكروموسومات علم الوراثة |
title | Protein-Protein Interaction Detection: Methods and Analysis |
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