Nuclear Pores Protect Genome Integrity by Assembling a Premitotic and Mad1-Dependent Anaphase Inhibitor

The spindle assembly checkpoint (SAC) delays anaphase until all chromosomes are bioriented on the mitotic spindle. Under current models, unattached kinetochores transduce the SAC by catalyzing the intramitotic production of a diffusible inhibitor of APC/CCdc20 (the anaphase-promoting complex/cycloso...

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Veröffentlicht in:	Cell 2014-02, Vol.156 (5), p.1017-1031
Hauptverfasser:	Rodriguez-Bravo, Veronica, Maciejowski, John, Corona, Jennifer, Buch, Håkon Kirkeby, Collin, Philippe, Kanemaki, Masato T., Shah, Jagesh V., Jallepalli, Prasad V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Anaphase Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Dimerization genome HCT116 Cells HeLa Cells Humans Interphase kinetochores Kinetochores - metabolism M Phase Cell Cycle Checkpoints Mad2 Proteins - metabolism Mitosis mitotic spindle apparatus Nuclear Pore - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism nucleoporins ubiquitin-protein ligase
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