Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat

Growing evidence suggests that oxidative stress, as associated with spinal cord injury (SCI), may play a critical role in both neuroinflammation and neuropathic pain conditions. The production of the endogenous aldehyde acrolein, following lipid peroxidation during the inflammatory response, may con...

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Veröffentlicht in:	Journal of neurochemistry 2014-03, Vol.128 (5), p.776-786
Hauptverfasser:	Due, Michael R., Park, Jonghyuck, Zheng, Lingxing, Walls, Michael, Allette, Yohance M., White, Fletcher A., Shi, Riyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrolein - administration & dosage Acrolein - metabolism Acrolein - pharmacology aldehyde Animals Behavior, Animal - physiology Behavioral psychology Blotting, Western Cold Temperature DNA, Complementary - biosynthesis DNA, Complementary - genetics Electrophysiological Phenomena - drug effects Ganglia, Sensory - metabolism Ganglia, Sensory - pathology Hot Temperature hydralazine Hydralazine - pharmacology hyperreflexia Inflammation - metabolism Inflammation - pathology Injections, Spinal lipid peroxidation Lipid Peroxidation - physiology Male Neuralgia - etiology Neuralgia - metabolism Neuralgia - pathology Nociceptors - physiology Oxidative stress Peripheral Nervous System Diseases - metabolism Peripheral Nervous System Diseases - pathology Physical Stimulation proalgesic Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Reflex, Abnormal - physiology RNA - genetics RNA - isolation & purification Rodents Spinal cord injuries Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology TRPA1 TRPA1 Cation Channel TRPC Cation Channels - metabolism
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