Effects of aging, CMV infection, and EBV infection on human B cell repertoires

Elderly humans show decreased humoral immunity to pathogens and vaccines, yet the effects of aging on B cells are not fully known. Chronic viral infection by cytomegalovirus (CMV) is implicated as a driver of clonal T cell proliferations in some aging humans, but whether CMV or Epstein-Barr virus (E...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-12, Vol.192 (2), p.603-611
Hauptverfasser:	Wang, Chen, Liu, Yi, Xu, Lan T., Jackson, Katherine J. L., Roskin, Krishna M., Pham, Tho D., Laserson, Jonathan, Marshall, Eleanor L., Seo, Katie, Lee, Ji-Yeun, Furman, David, Koller, Daphne, Dekker, Cornelia L., Davis, Mark M., Fire, Andrew Z., Boyd, Scott D.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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