Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development
Purpose We hypothesised that varying native oocyte-secreted factor (OSF) exposure or using different recombinant OSF peptides would have differential effects on post-in vitro maturation (IVM) embryo and fetal development. Methods Mouse cumulus oocyte complexes (COCs) were treated with the purified m...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2014-03, Vol.31 (3), p.295-306 |
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| creator | Sudiman, J. Ritter, L. J. Feil, D. K. Wang, X. Chan, K. Mottershead, D. G. Robertson, D. M. Thompson, J. G. Gilchrist, R. B. |
| description | Purpose
We hypothesised that varying native oocyte-secreted factor (OSF) exposure or using different recombinant OSF peptides would have differential effects on post-in vitro maturation (IVM) embryo and fetal development.
Methods
Mouse cumulus oocyte complexes (COCs) were treated with the purified mature domain of GDF9 and/or BMP15 or were co-cultured with denuded oocytes (DOs) from 0 h or 3 h of IVM. DOs were matured for 3 h as either intact COCs+/-FSH before denuding, or as DOs + FSH. COCs were fertilised and blastocyst development was assessed on days 5 and 6, and either differentially stained for ICM numbers or vitrified/warmed embryos were transferred to recipients to assess implantation and fetal rates.
Results
No improvement in embryo development was observed with the addition of GDF9 and/or BMP15 to IVM. In contrast, embryos derived from COCs co-cultured with DOs had significantly improved blastocyst rates and ICM numbers compared to controls (
P
|
| doi_str_mv | 10.1007/s10815-013-0152-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3947075</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1508757848</sourcerecordid><originalsourceid>FETCH-LOGICAL-c569t-c0a2c85b39b4be8ad54414c114ab746c72c53ca28121d6d5769b7c9813198a153</originalsourceid><addsrcrecordid>eNqNUl2L1TAQLaK4H_oDfJGAL75UZ5qkSV8EWdZVWPBFn0OaTtcsbXNN0ov335t612UVBCEhA3PmnMzMqaoXCG8QQL1NCBplDcjLlU0tH1WnKBWvFefwuMQgdQ2i1SfVWUq3ANDphj-tThohSqXmp9WPy3EklxMLIxt8iaNfblgI7pCpTuQiZRrYaF0OMbFh_ZWew5qI-YXtfY6BzTav0WYfFlZOWvtE31daMqO5j4fA7FIYKNuJDbSnKezmknxWPRntlOj53Xteff1w-eXiY339-erTxfvr2sm2y7UD2zgte971oidtBykECocobK9E61TjJHe20djg0A5StV2vXKeRY6ctSn5evTvy7tZ-psEV6Wgns4t-tvFggvXmz8ziv5mbsDe8EwrURvD6jiCG0lbKZvbJ0TTZhcocDErQSiot9P9AW4EKQBToq7-gt2GNS5nEhpKgOs43bTyiXAwpRRrv_41gNguYowVMsYDZLGC2mpcPG76v-L3zAmiOgLTbtknxgfQ_WX8CqQy9zA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1505079335</pqid></control><display><type>article</type><title>Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Sudiman, J. ; Ritter, L. J. ; Feil, D. K. ; Wang, X. ; Chan, K. ; Mottershead, D. G. ; Robertson, D. M. ; Thompson, J. G. ; Gilchrist, R. B.</creator><creatorcontrib>Sudiman, J. ; Ritter, L. J. ; Feil, D. K. ; Wang, X. ; Chan, K. ; Mottershead, D. G. ; Robertson, D. M. ; Thompson, J. G. ; Gilchrist, R. B.</creatorcontrib><description>Purpose
We hypothesised that varying native oocyte-secreted factor (OSF) exposure or using different recombinant OSF peptides would have differential effects on post-in vitro maturation (IVM) embryo and fetal development.
Methods
Mouse cumulus oocyte complexes (COCs) were treated with the purified mature domain of GDF9 and/or BMP15 or were co-cultured with denuded oocytes (DOs) from 0 h or 3 h of IVM. DOs were matured for 3 h as either intact COCs+/-FSH before denuding, or as DOs + FSH. COCs were fertilised and blastocyst development was assessed on days 5 and 6, and either differentially stained for ICM numbers or vitrified/warmed embryos were transferred to recipients to assess implantation and fetal rates.
Results
No improvement in embryo development was observed with the addition of GDF9 and/or BMP15 to IVM. In contrast, embryos derived from COCs co-cultured with DOs had significantly improved blastocyst rates and ICM numbers compared to controls (
P
< 0.05). The highest response was obtained when DOs were first added to COCs at 3 h of IVM, after being pre-treated (0–3 h) as COCs + FSH. Compared to control, co-culture with DOs from 3 h did not affect implantation rates but more than doubled fetal yield (21 % vs 48 %;
P
< 0.05). GDF9 Western blot analysis was unable to detect any differences in quantity or form of GDF9 (17 and 65 kDa) in extracts of DO at 0 h or 3 h.
Conclusions
This study provides new knowledge on means to improve oocyte quality in vitro which has the potential to significantly aid human infertility treatment and animal embryo production technologies.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-013-0152-5</identifier><identifier>PMID: 24408183</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Blastocyst - cytology ; Bone Morphogenetic Protein 15 - genetics ; Coculture Techniques ; Communication ; Cumulus Cells - cytology ; Cumulus Cells - metabolism ; Embryonic Development - genetics ; Embryos ; Female ; Follicles ; Gamete Biology ; Growth Differentiation Factor 9 - genetics ; Gynecology ; Human Genetics ; Humans ; In vitro fertilization ; Infertility ; Medicine ; Medicine & Public Health ; Mice ; Mutation ; Oocytes - cytology ; Oocytes - metabolism ; Ovarian Follicle - cytology ; Ovaries ; Ovulation ; Pregnancy ; Proteins ; Reproductive health ; Reproductive Medicine ; Reproductive technologies ; Sheep</subject><ispartof>Journal of assisted reproduction and genetics, 2014-03, Vol.31 (3), p.295-306</ispartof><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-c0a2c85b39b4be8ad54414c114ab746c72c53ca28121d6d5769b7c9813198a153</citedby><cites>FETCH-LOGICAL-c569t-c0a2c85b39b4be8ad54414c114ab746c72c53ca28121d6d5769b7c9813198a153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947075/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947075/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24408183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sudiman, J.</creatorcontrib><creatorcontrib>Ritter, L. J.</creatorcontrib><creatorcontrib>Feil, D. K.</creatorcontrib><creatorcontrib>Wang, X.</creatorcontrib><creatorcontrib>Chan, K.</creatorcontrib><creatorcontrib>Mottershead, D. G.</creatorcontrib><creatorcontrib>Robertson, D. M.</creatorcontrib><creatorcontrib>Thompson, J. G.</creatorcontrib><creatorcontrib>Gilchrist, R. B.</creatorcontrib><title>Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Purpose
We hypothesised that varying native oocyte-secreted factor (OSF) exposure or using different recombinant OSF peptides would have differential effects on post-in vitro maturation (IVM) embryo and fetal development.
Methods
Mouse cumulus oocyte complexes (COCs) were treated with the purified mature domain of GDF9 and/or BMP15 or were co-cultured with denuded oocytes (DOs) from 0 h or 3 h of IVM. DOs were matured for 3 h as either intact COCs+/-FSH before denuding, or as DOs + FSH. COCs were fertilised and blastocyst development was assessed on days 5 and 6, and either differentially stained for ICM numbers or vitrified/warmed embryos were transferred to recipients to assess implantation and fetal rates.
Results
No improvement in embryo development was observed with the addition of GDF9 and/or BMP15 to IVM. In contrast, embryos derived from COCs co-cultured with DOs had significantly improved blastocyst rates and ICM numbers compared to controls (
P
< 0.05). The highest response was obtained when DOs were first added to COCs at 3 h of IVM, after being pre-treated (0–3 h) as COCs + FSH. Compared to control, co-culture with DOs from 3 h did not affect implantation rates but more than doubled fetal yield (21 % vs 48 %;
P
< 0.05). GDF9 Western blot analysis was unable to detect any differences in quantity or form of GDF9 (17 and 65 kDa) in extracts of DO at 0 h or 3 h.
Conclusions
This study provides new knowledge on means to improve oocyte quality in vitro which has the potential to significantly aid human infertility treatment and animal embryo production technologies.</description><subject>Animals</subject><subject>Blastocyst - cytology</subject><subject>Bone Morphogenetic Protein 15 - genetics</subject><subject>Coculture Techniques</subject><subject>Communication</subject><subject>Cumulus Cells - cytology</subject><subject>Cumulus Cells - metabolism</subject><subject>Embryonic Development - genetics</subject><subject>Embryos</subject><subject>Female</subject><subject>Follicles</subject><subject>Gamete Biology</subject><subject>Growth Differentiation Factor 9 - genetics</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>Infertility</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Mutation</subject><subject>Oocytes - cytology</subject><subject>Oocytes - metabolism</subject><subject>Ovarian Follicle - cytology</subject><subject>Ovaries</subject><subject>Ovulation</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>Reproductive health</subject><subject>Reproductive Medicine</subject><subject>Reproductive technologies</subject><subject>Sheep</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNUl2L1TAQLaK4H_oDfJGAL75UZ5qkSV8EWdZVWPBFn0OaTtcsbXNN0ov335t612UVBCEhA3PmnMzMqaoXCG8QQL1NCBplDcjLlU0tH1WnKBWvFefwuMQgdQ2i1SfVWUq3ANDphj-tThohSqXmp9WPy3EklxMLIxt8iaNfblgI7pCpTuQiZRrYaF0OMbFh_ZWew5qI-YXtfY6BzTav0WYfFlZOWvtE31daMqO5j4fA7FIYKNuJDbSnKezmknxWPRntlOj53Xteff1w-eXiY339-erTxfvr2sm2y7UD2zgte971oidtBykECocobK9E61TjJHe20djg0A5StV2vXKeRY6ctSn5evTvy7tZ-psEV6Wgns4t-tvFggvXmz8ziv5mbsDe8EwrURvD6jiCG0lbKZvbJ0TTZhcocDErQSiot9P9AW4EKQBToq7-gt2GNS5nEhpKgOs43bTyiXAwpRRrv_41gNguYowVMsYDZLGC2mpcPG76v-L3zAmiOgLTbtknxgfQ_WX8CqQy9zA</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Sudiman, J.</creator><creator>Ritter, L. J.</creator><creator>Feil, D. K.</creator><creator>Wang, X.</creator><creator>Chan, K.</creator><creator>Mottershead, D. G.</creator><creator>Robertson, D. M.</creator><creator>Thompson, J. G.</creator><creator>Gilchrist, R. B.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140301</creationdate><title>Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development</title><author>Sudiman, J. ; Ritter, L. J. ; Feil, D. K. ; Wang, X. ; Chan, K. ; Mottershead, D. G. ; Robertson, D. M. ; Thompson, J. G. ; Gilchrist, R. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c569t-c0a2c85b39b4be8ad54414c114ab746c72c53ca28121d6d5769b7c9813198a153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Blastocyst - cytology</topic><topic>Bone Morphogenetic Protein 15 - genetics</topic><topic>Coculture Techniques</topic><topic>Communication</topic><topic>Cumulus Cells - cytology</topic><topic>Cumulus Cells - metabolism</topic><topic>Embryonic Development - genetics</topic><topic>Embryos</topic><topic>Female</topic><topic>Follicles</topic><topic>Gamete Biology</topic><topic>Growth Differentiation Factor 9 - genetics</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>Infertility</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Mutation</topic><topic>Oocytes - cytology</topic><topic>Oocytes - metabolism</topic><topic>Ovarian Follicle - cytology</topic><topic>Ovaries</topic><topic>Ovulation</topic><topic>Pregnancy</topic><topic>Proteins</topic><topic>Reproductive health</topic><topic>Reproductive Medicine</topic><topic>Reproductive technologies</topic><topic>Sheep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sudiman, J.</creatorcontrib><creatorcontrib>Ritter, L. J.</creatorcontrib><creatorcontrib>Feil, D. K.</creatorcontrib><creatorcontrib>Wang, X.</creatorcontrib><creatorcontrib>Chan, K.</creatorcontrib><creatorcontrib>Mottershead, D. G.</creatorcontrib><creatorcontrib>Robertson, D. M.</creatorcontrib><creatorcontrib>Thompson, J. G.</creatorcontrib><creatorcontrib>Gilchrist, R. B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sudiman, J.</au><au>Ritter, L. J.</au><au>Feil, D. K.</au><au>Wang, X.</au><au>Chan, K.</au><au>Mottershead, D. G.</au><au>Robertson, D. M.</au><au>Thompson, J. G.</au><au>Gilchrist, R. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>31</volume><issue>3</issue><spage>295</spage><epage>306</epage><pages>295-306</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>Purpose
We hypothesised that varying native oocyte-secreted factor (OSF) exposure or using different recombinant OSF peptides would have differential effects on post-in vitro maturation (IVM) embryo and fetal development.
Methods
Mouse cumulus oocyte complexes (COCs) were treated with the purified mature domain of GDF9 and/or BMP15 or were co-cultured with denuded oocytes (DOs) from 0 h or 3 h of IVM. DOs were matured for 3 h as either intact COCs+/-FSH before denuding, or as DOs + FSH. COCs were fertilised and blastocyst development was assessed on days 5 and 6, and either differentially stained for ICM numbers or vitrified/warmed embryos were transferred to recipients to assess implantation and fetal rates.
Results
No improvement in embryo development was observed with the addition of GDF9 and/or BMP15 to IVM. In contrast, embryos derived from COCs co-cultured with DOs had significantly improved blastocyst rates and ICM numbers compared to controls (
P
< 0.05). The highest response was obtained when DOs were first added to COCs at 3 h of IVM, after being pre-treated (0–3 h) as COCs + FSH. Compared to control, co-culture with DOs from 3 h did not affect implantation rates but more than doubled fetal yield (21 % vs 48 %;
P
< 0.05). GDF9 Western blot analysis was unable to detect any differences in quantity or form of GDF9 (17 and 65 kDa) in extracts of DO at 0 h or 3 h.
Conclusions
This study provides new knowledge on means to improve oocyte quality in vitro which has the potential to significantly aid human infertility treatment and animal embryo production technologies.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24408183</pmid><doi>10.1007/s10815-013-0152-5</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of assisted reproduction and genetics, 2014-03, Vol.31 (3), p.295-306 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Blastocyst - cytology Bone Morphogenetic Protein 15 - genetics Coculture Techniques Communication Cumulus Cells - cytology Cumulus Cells - metabolism Embryonic Development - genetics Embryos Female Follicles Gamete Biology Growth Differentiation Factor 9 - genetics Gynecology Human Genetics Humans In vitro fertilization Infertility Medicine Medicine & Public Health Mice Mutation Oocytes - cytology Oocytes - metabolism Ovarian Follicle - cytology Ovaries Ovulation Pregnancy Proteins Reproductive health Reproductive Medicine Reproductive technologies Sheep |
| title | Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development |
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