C1q binding to Dengue Virus inhibits infection of THP-1 and cellular inflammatory responses
Dengue virus infection elicits a spectrum of clinical presentations ranging from asymptomatic to severe disease. The mechanisms leading to severe dengue are not known, however it has been reported that the complement system is hyper-activated in severe dengue. Screening of complement proteins demons...
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| Veröffentlicht in: | Virus research 2013-11, Vol.179, p.231-234 |
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| container_title | Virus research |
| container_volume | 179 |
| creator | Douradinha, Bruno McBurney, Sean P. de Melo, Klecia M. Soares Smith, Amanda P. Krishna, Neel K. Barratt-Boyes, Simon M. Evans, Jared D. Nascimento, Eduardo J. M. Marques, Ernesto T. A |
| description | Dengue virus infection elicits a spectrum of clinical presentations ranging from asymptomatic to severe disease. The mechanisms leading to severe dengue are not known, however it has been reported that the complement system is hyper-activated in severe dengue. Screening of complement proteins demonstrated that C1q, a pattern recognition molecule, can bind directly to Dengue Virus Envelope protein and to whole Dengue Virus serotype 2. Incubation of Dengue Virus serotype 2 with C1q prior to infection of THP-1 cells led to decreased virus infectivity and modulation of mRNA expression of immunoregulatory molecules suggesting reduced inflammatory responses. |
| doi_str_mv | 10.1016/j.virusres.2013.11.007 |
| format | Article |
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| ispartof | Virus research, 2013-11, Vol.179, p.231-234 |
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| title | C1q binding to Dengue Virus inhibits infection of THP-1 and cellular inflammatory responses |
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