Mucin can enhance growth, biofilm formation, and survival of Streptococcus mutans
Abstract Streptococcus mutans is a member of the dental plaque and is the primary causative agent of dental caries. It can survive extended periods of starvation, which may occur in different niches within the oral cavity. We have found that mucin compensated for the absence of amino acids to promot...
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| Veröffentlicht in: | FEMS microbiology letters 2014-01, Vol.350 (2), p.161-167 |
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| creator | Mothey, Deepa Buttaro, Bettina A. Piggot, Patrick J. |
| description | Abstract
Streptococcus mutans is a member of the dental plaque and is the primary causative agent of dental caries. It can survive extended periods of starvation, which may occur in different niches within the oral cavity. We have found that mucin compensated for the absence of amino acids to promote exponential growth and biofilm formation of S. mutans in minimal medium supplemented with glucose and sucrose, respectively. Mucin extended survival in conditions where there was no net growth provided the operon encoding the pyruvate dehydrogenase complex was intact. Mucin extended survival in conditions of amino acid sufficiency provided the tagatose pathway for galactose utilization was intact, suggesting that S. mutans can scavenge sufficient galactose from mucin to enhance survival, although not to serve as a primary carbon and energy source. The results suggest that mucin has a metabolic role in promoting survival of S. mutans.
Mucin enhances the survival of Streptococcus mutans, the primary causative agent of dental caries. |
| doi_str_mv | 10.1111/1574-6968.12336 |
| format | Article |
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Streptococcus mutans is a member of the dental plaque and is the primary causative agent of dental caries. It can survive extended periods of starvation, which may occur in different niches within the oral cavity. We have found that mucin compensated for the absence of amino acids to promote exponential growth and biofilm formation of S. mutans in minimal medium supplemented with glucose and sucrose, respectively. Mucin extended survival in conditions where there was no net growth provided the operon encoding the pyruvate dehydrogenase complex was intact. Mucin extended survival in conditions of amino acid sufficiency provided the tagatose pathway for galactose utilization was intact, suggesting that S. mutans can scavenge sufficient galactose from mucin to enhance survival, although not to serve as a primary carbon and energy source. The results suggest that mucin has a metabolic role in promoting survival of S. mutans.
Mucin enhances the survival of Streptococcus mutans, the primary causative agent of dental caries.</description><identifier>ISSN: 0378-1097</identifier><identifier>EISSN: 1574-6968</identifier><identifier>DOI: 10.1111/1574-6968.12336</identifier><identifier>PMID: 24261873</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Amino acids ; Animals ; biofilm ; Biofilms ; Biofilms - drug effects ; Biofilms - growth & development ; carbon ; Colony Count, Microbial ; dental caries ; energy ; Energy sources ; galactose ; Glucose ; Microbial Viability - drug effects ; Microbiology ; mouth ; mucins ; Mucins - pharmacology ; niches ; operon ; pyruvate dehydrogenase ; pyruvate dehydrogenase (lipoamide) ; starvation ; Streptococcus mutans ; Streptococcus mutans - drug effects ; Streptococcus mutans - genetics ; Sucrose ; Survival ; Swine ; tagatose ; tagatose path</subject><ispartof>FEMS microbiology letters, 2014-01, Vol.350 (2), p.161-167</ispartof><rights>2013 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved 2013</rights><rights>2013 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved</rights><rights>2013 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.</rights><rights>Copyright © 2014 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5276-90f2f0e9c4627b467b60542de3d6855efc25666bd694617deb6de1708c9a3c5f3</citedby><cites>FETCH-LOGICAL-c5276-90f2f0e9c4627b467b60542de3d6855efc25666bd694617deb6de1708c9a3c5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1574-6968.12336$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1574-6968.12336$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,778,782,883,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24261873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mothey, Deepa</creatorcontrib><creatorcontrib>Buttaro, Bettina A.</creatorcontrib><creatorcontrib>Piggot, Patrick J.</creatorcontrib><title>Mucin can enhance growth, biofilm formation, and survival of Streptococcus mutans</title><title>FEMS microbiology letters</title><addtitle>FEMS Microbiol Lett</addtitle><description>Abstract
Streptococcus mutans is a member of the dental plaque and is the primary causative agent of dental caries. It can survive extended periods of starvation, which may occur in different niches within the oral cavity. We have found that mucin compensated for the absence of amino acids to promote exponential growth and biofilm formation of S. mutans in minimal medium supplemented with glucose and sucrose, respectively. Mucin extended survival in conditions where there was no net growth provided the operon encoding the pyruvate dehydrogenase complex was intact. Mucin extended survival in conditions of amino acid sufficiency provided the tagatose pathway for galactose utilization was intact, suggesting that S. mutans can scavenge sufficient galactose from mucin to enhance survival, although not to serve as a primary carbon and energy source. The results suggest that mucin has a metabolic role in promoting survival of S. mutans.
Mucin enhances the survival of Streptococcus mutans, the primary causative agent of dental caries.</description><subject>Amino acids</subject><subject>Animals</subject><subject>biofilm</subject><subject>Biofilms</subject><subject>Biofilms - drug effects</subject><subject>Biofilms - growth & development</subject><subject>carbon</subject><subject>Colony Count, Microbial</subject><subject>dental caries</subject><subject>energy</subject><subject>Energy sources</subject><subject>galactose</subject><subject>Glucose</subject><subject>Microbial Viability - drug effects</subject><subject>Microbiology</subject><subject>mouth</subject><subject>mucins</subject><subject>Mucins - pharmacology</subject><subject>niches</subject><subject>operon</subject><subject>pyruvate dehydrogenase</subject><subject>pyruvate dehydrogenase (lipoamide)</subject><subject>starvation</subject><subject>Streptococcus mutans</subject><subject>Streptococcus mutans - drug effects</subject><subject>Streptococcus mutans - genetics</subject><subject>Sucrose</subject><subject>Survival</subject><subject>Swine</subject><subject>tagatose</subject><subject>tagatose path</subject><issn>0378-1097</issn><issn>1574-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9rFDEUx4Motq6evUnAi0inzc-XzKUgxaqwRUQ9h0wm002ZSdZkZkv_e2fddqkibC6B5PM-JO_7EHpNySmd1xmVSlRQgz6ljHN4go73J0_RMeFKV5TU6gi9KOWGECIYgefoiAkGVCt-jL5dTS5E7GzEPq5sdB5f53Q7rk5wE1IX-gF3KQ92DCmeYBtbXKa8CRvb49Th72P26zG55NxU8DCNNpaX6Fln--Jf3e8L9PPy44-Lz9Xy66cvFx-WlZNMQVWTjnXE104AU40A1QCRgrWet6Cl9J1jEgCaFmoBVLW-gdZTRbSrLXey4wt0vvOup2bwrfNxzLY36xwGm-9MssH8fRPDylynjeGzUAs5C97dC3L6NfkymiEU5_veRp-mYqjiXPKaKXoYlURywTWQw6ioGWgQc_cX6O0_6E2acpybNgs5oVpLBTN1tqNcTqVk3-2_SInZDoHZRm62kZs_QzBXvHncmT3_kPoMyB1wG3p_d8hnLq-WD-L3u7o0rf9bVT16xW9gHMdA</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Mothey, Deepa</creator><creator>Buttaro, Bettina A.</creator><creator>Piggot, Patrick J.</creator><general>Blackwell Publishing Ltd</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>201401</creationdate><title>Mucin can enhance growth, biofilm formation, and survival of Streptococcus mutans</title><author>Mothey, Deepa ; Buttaro, Bettina A. ; Piggot, Patrick J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5276-90f2f0e9c4627b467b60542de3d6855efc25666bd694617deb6de1708c9a3c5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Amino acids</topic><topic>Animals</topic><topic>biofilm</topic><topic>Biofilms</topic><topic>Biofilms - drug effects</topic><topic>Biofilms - growth & development</topic><topic>carbon</topic><topic>Colony Count, Microbial</topic><topic>dental caries</topic><topic>energy</topic><topic>Energy sources</topic><topic>galactose</topic><topic>Glucose</topic><topic>Microbial Viability - drug effects</topic><topic>Microbiology</topic><topic>mouth</topic><topic>mucins</topic><topic>Mucins - pharmacology</topic><topic>niches</topic><topic>operon</topic><topic>pyruvate dehydrogenase</topic><topic>pyruvate dehydrogenase (lipoamide)</topic><topic>starvation</topic><topic>Streptococcus mutans</topic><topic>Streptococcus mutans - drug effects</topic><topic>Streptococcus mutans - genetics</topic><topic>Sucrose</topic><topic>Survival</topic><topic>Swine</topic><topic>tagatose</topic><topic>tagatose path</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mothey, Deepa</creatorcontrib><creatorcontrib>Buttaro, Bettina A.</creatorcontrib><creatorcontrib>Piggot, Patrick J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>FEMS microbiology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mothey, Deepa</au><au>Buttaro, Bettina A.</au><au>Piggot, Patrick J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucin can enhance growth, biofilm formation, and survival of Streptococcus mutans</atitle><jtitle>FEMS microbiology letters</jtitle><addtitle>FEMS Microbiol Lett</addtitle><date>2014-01</date><risdate>2014</risdate><volume>350</volume><issue>2</issue><spage>161</spage><epage>167</epage><pages>161-167</pages><issn>0378-1097</issn><eissn>1574-6968</eissn><abstract>Abstract
Streptococcus mutans is a member of the dental plaque and is the primary causative agent of dental caries. It can survive extended periods of starvation, which may occur in different niches within the oral cavity. We have found that mucin compensated for the absence of amino acids to promote exponential growth and biofilm formation of S. mutans in minimal medium supplemented with glucose and sucrose, respectively. Mucin extended survival in conditions where there was no net growth provided the operon encoding the pyruvate dehydrogenase complex was intact. Mucin extended survival in conditions of amino acid sufficiency provided the tagatose pathway for galactose utilization was intact, suggesting that S. mutans can scavenge sufficient galactose from mucin to enhance survival, although not to serve as a primary carbon and energy source. The results suggest that mucin has a metabolic role in promoting survival of S. mutans.
Mucin enhances the survival of Streptococcus mutans, the primary causative agent of dental caries.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>24261873</pmid><doi>10.1111/1574-6968.12336</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0378-1097 |
| ispartof | FEMS microbiology letters, 2014-01, Vol.350 (2), p.161-167 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Amino acids Animals biofilm Biofilms Biofilms - drug effects Biofilms - growth & development carbon Colony Count, Microbial dental caries energy Energy sources galactose Glucose Microbial Viability - drug effects Microbiology mouth mucins Mucins - pharmacology niches operon pyruvate dehydrogenase pyruvate dehydrogenase (lipoamide) starvation Streptococcus mutans Streptococcus mutans - drug effects Streptococcus mutans - genetics Sucrose Survival Swine tagatose tagatose path |
| title | Mucin can enhance growth, biofilm formation, and survival of Streptococcus mutans |
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