Older individuals with HIV infection have greater memory deficits than younger individuals
The prevalence of HIV-associated neurocognitive disorder (HAND) remains persistently high in the era of combination antiretroviral therapy. We aimed to characterize the pattern of neurocognitive dysfunction in older subjects with HAND in particular amnestic versus non-amnestic impairment. One hundre...
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| Veröffentlicht in: | Journal of neurovirology 2013-12, Vol.19 (6), p.531-536 |
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| creator | Tan, I. Lin Smith, B. R. Hammond, Edward Vornbrock-Roosa, Heidi Creighton, Jason Selnes, O. McArthur, Justin C. Sacktor, Ned |
| description | The prevalence of HIV-associated neurocognitive disorder (HAND) remains persistently high in the era of combination antiretroviral therapy. We aimed to characterize the pattern of neurocognitive dysfunction in older subjects with HAND in particular amnestic versus non-amnestic impairment. One hundred six subjects from the Johns Hopkins University NIMH Clinical Outcomes cohort underwent standardized neuropsychological (NP) testing between November 2006 and June 2010. We examined performance in seven cognitive domains (memory, attention, speed of processing, visuospatial, language, motor, and executive). Older subjects were defined as age >50 years at the time of NP testing. Subjects were diagnosed with HAND according to established criteria and dichotomized into amnestic cognitive impairment or non-amnestic cognitive impairment with deficit defined as
z
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| doi_str_mv | 10.1007/s13365-013-0209-3 |
| format | Article |
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z
scores <−1.5 for the verbal and nonverbal memory domains. There were 32 older subjects with a mean age (SD) of 54.2 (2.8) years and 74 younger subjects, 43.7 (4.3) years. Older age was associated with a 4.8-fold higher odds of memory deficits adjusted for potential confounders (
p
= 0.035) identified a priori. With age modeled as a continuous covariate, every 1 year increase in age was associated with a 1.11-fold higher odds of memory deficit (
p
= 0.05). There was a higher proportion of amnestic cognitive impairment among older subjects than younger subjects with HIV infection. Neurodegenerative processes other than those directly due to HIV may be increasingly important as individuals with chronic HIV infection and HAND survive into older age.</description><identifier>ISSN: 1355-0284</identifier><identifier>EISSN: 1538-2443</identifier><identifier>DOI: 10.1007/s13365-013-0209-3</identifier><identifier>PMID: 24078559</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Age Factors ; Amnesia - etiology ; Amnesia - psychology ; Amnesia - virology ; Anti-HIV Agents - therapeutic use ; Attention ; Biomedical and Life Sciences ; Biomedicine ; Cognition ; Cognition Disorders - etiology ; Cognition Disorders - psychology ; Cognition Disorders - virology ; Executive Function ; Female ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - psychology ; HIV-1 ; Human immunodeficiency virus ; Humans ; Immunology ; Infectious Diseases ; Male ; Memory ; Middle Aged ; Motor Activity ; Neurology ; Neuropsychological Tests ; Neurosciences ; Severity of Illness Index ; Speech ; Virology</subject><ispartof>Journal of neurovirology, 2013-12, Vol.19 (6), p.531-536</ispartof><rights>Journal of NeuroVirology, Inc. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-18951029a62542091edca4b90609ac050b73efc65ca832974c72182ff22e58723</citedby><cites>FETCH-LOGICAL-c475t-18951029a62542091edca4b90609ac050b73efc65ca832974c72182ff22e58723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13365-013-0209-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13365-013-0209-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24078559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, I. Lin</creatorcontrib><creatorcontrib>Smith, B. R.</creatorcontrib><creatorcontrib>Hammond, Edward</creatorcontrib><creatorcontrib>Vornbrock-Roosa, Heidi</creatorcontrib><creatorcontrib>Creighton, Jason</creatorcontrib><creatorcontrib>Selnes, O.</creatorcontrib><creatorcontrib>McArthur, Justin C.</creatorcontrib><creatorcontrib>Sacktor, Ned</creatorcontrib><title>Older individuals with HIV infection have greater memory deficits than younger individuals</title><title>Journal of neurovirology</title><addtitle>J. Neurovirol</addtitle><addtitle>J Neurovirol</addtitle><description>The prevalence of HIV-associated neurocognitive disorder (HAND) remains persistently high in the era of combination antiretroviral therapy. We aimed to characterize the pattern of neurocognitive dysfunction in older subjects with HAND in particular amnestic versus non-amnestic impairment. One hundred six subjects from the Johns Hopkins University NIMH Clinical Outcomes cohort underwent standardized neuropsychological (NP) testing between November 2006 and June 2010. We examined performance in seven cognitive domains (memory, attention, speed of processing, visuospatial, language, motor, and executive). Older subjects were defined as age >50 years at the time of NP testing. Subjects were diagnosed with HAND according to established criteria and dichotomized into amnestic cognitive impairment or non-amnestic cognitive impairment with deficit defined as
z
scores <−1.5 for the verbal and nonverbal memory domains. There were 32 older subjects with a mean age (SD) of 54.2 (2.8) years and 74 younger subjects, 43.7 (4.3) years. Older age was associated with a 4.8-fold higher odds of memory deficits adjusted for potential confounders (
p
= 0.035) identified a priori. With age modeled as a continuous covariate, every 1 year increase in age was associated with a 1.11-fold higher odds of memory deficit (
p
= 0.05). There was a higher proportion of amnestic cognitive impairment among older subjects than younger subjects with HIV infection. Neurodegenerative processes other than those directly due to HIV may be increasingly important as individuals with chronic HIV infection and HAND survive into older age.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Amnesia - etiology</subject><subject>Amnesia - psychology</subject><subject>Amnesia - virology</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Attention</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cognition</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - psychology</subject><subject>Cognition Disorders - virology</subject><subject>Executive Function</subject><subject>Female</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - psychology</subject><subject>HIV-1</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>Male</subject><subject>Memory</subject><subject>Middle Aged</subject><subject>Motor Activity</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Neurosciences</subject><subject>Severity of Illness Index</subject><subject>Speech</subject><subject>Virology</subject><issn>1355-0284</issn><issn>1538-2443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UbtOwzAUtRCIlsIHsKCMLAE_43hBQhXQSpW6AAOL5TpO6yqJi50U9e9xlVLBwnQtn8e1zwHgGsE7BCG_D4iQjKUQkRRiKFJyAoaIkTzFlJLTeCYsojinA3ARwhpGYobzczDAFPKcMTEEH_OqMD6xTWG3tuhUFZIv266SyfQ9XpZGt9Y1yUptTbL0RrWRW5va-V1SmNJq24akXakm2bmuWf41ugRnZRzm6jBH4O356XU8SWfzl-n4cZZqylmbolwwBLFQGWY0_gKZQiu6EDCDQmnI4IITU-qMaZUTLDjVHKMclyXGhuUckxF46H033aKOYtO0XlVy422t_E46ZeVfpLEruXRbSQTNMsGjwe3BwLvPzoRW1jZoU1WqMa4LErEYdgY5g5GKeqr2LgRvyuMaBOW-E9l3ImPUct-JJFFz8_t9R8VPCZGAe0KI0D5FuXadb2Jm_7h-A4AemCo</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Tan, I. Lin</creator><creator>Smith, B. R.</creator><creator>Hammond, Edward</creator><creator>Vornbrock-Roosa, Heidi</creator><creator>Creighton, Jason</creator><creator>Selnes, O.</creator><creator>McArthur, Justin C.</creator><creator>Sacktor, Ned</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20131201</creationdate><title>Older individuals with HIV infection have greater memory deficits than younger individuals</title><author>Tan, I. Lin ; Smith, B. R. ; Hammond, Edward ; Vornbrock-Roosa, Heidi ; Creighton, Jason ; Selnes, O. ; McArthur, Justin C. ; Sacktor, Ned</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-18951029a62542091edca4b90609ac050b73efc65ca832974c72182ff22e58723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Amnesia - etiology</topic><topic>Amnesia - psychology</topic><topic>Amnesia - virology</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Attention</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cognition</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - psychology</topic><topic>Cognition Disorders - virology</topic><topic>Executive Function</topic><topic>Female</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - psychology</topic><topic>HIV-1</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunology</topic><topic>Infectious Diseases</topic><topic>Male</topic><topic>Memory</topic><topic>Middle Aged</topic><topic>Motor Activity</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Neurosciences</topic><topic>Severity of Illness Index</topic><topic>Speech</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, I. Lin</creatorcontrib><creatorcontrib>Smith, B. R.</creatorcontrib><creatorcontrib>Hammond, Edward</creatorcontrib><creatorcontrib>Vornbrock-Roosa, Heidi</creatorcontrib><creatorcontrib>Creighton, Jason</creatorcontrib><creatorcontrib>Selnes, O.</creatorcontrib><creatorcontrib>McArthur, Justin C.</creatorcontrib><creatorcontrib>Sacktor, Ned</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurovirology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, I. Lin</au><au>Smith, B. R.</au><au>Hammond, Edward</au><au>Vornbrock-Roosa, Heidi</au><au>Creighton, Jason</au><au>Selnes, O.</au><au>McArthur, Justin C.</au><au>Sacktor, Ned</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Older individuals with HIV infection have greater memory deficits than younger individuals</atitle><jtitle>Journal of neurovirology</jtitle><stitle>J. Neurovirol</stitle><addtitle>J Neurovirol</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>19</volume><issue>6</issue><spage>531</spage><epage>536</epage><pages>531-536</pages><issn>1355-0284</issn><eissn>1538-2443</eissn><abstract>The prevalence of HIV-associated neurocognitive disorder (HAND) remains persistently high in the era of combination antiretroviral therapy. We aimed to characterize the pattern of neurocognitive dysfunction in older subjects with HAND in particular amnestic versus non-amnestic impairment. One hundred six subjects from the Johns Hopkins University NIMH Clinical Outcomes cohort underwent standardized neuropsychological (NP) testing between November 2006 and June 2010. We examined performance in seven cognitive domains (memory, attention, speed of processing, visuospatial, language, motor, and executive). Older subjects were defined as age >50 years at the time of NP testing. Subjects were diagnosed with HAND according to established criteria and dichotomized into amnestic cognitive impairment or non-amnestic cognitive impairment with deficit defined as
z
scores <−1.5 for the verbal and nonverbal memory domains. There were 32 older subjects with a mean age (SD) of 54.2 (2.8) years and 74 younger subjects, 43.7 (4.3) years. Older age was associated with a 4.8-fold higher odds of memory deficits adjusted for potential confounders (
p
= 0.035) identified a priori. With age modeled as a continuous covariate, every 1 year increase in age was associated with a 1.11-fold higher odds of memory deficit (
p
= 0.05). There was a higher proportion of amnestic cognitive impairment among older subjects than younger subjects with HIV infection. Neurodegenerative processes other than those directly due to HIV may be increasingly important as individuals with chronic HIV infection and HAND survive into older age.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24078559</pmid><doi>10.1007/s13365-013-0209-3</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Factors Amnesia - etiology Amnesia - psychology Amnesia - virology Anti-HIV Agents - therapeutic use Attention Biomedical and Life Sciences Biomedicine Cognition Cognition Disorders - etiology Cognition Disorders - psychology Cognition Disorders - virology Executive Function Female HIV Infections - complications HIV Infections - drug therapy HIV Infections - psychology HIV-1 Human immunodeficiency virus Humans Immunology Infectious Diseases Male Memory Middle Aged Motor Activity Neurology Neuropsychological Tests Neurosciences Severity of Illness Index Speech Virology |
| title | Older individuals with HIV infection have greater memory deficits than younger individuals |
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