Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling

The hepatic hormone hepcidin is a key regulator of systemic iron metabolism. Its expression is largely regulated by 2 signaling pathways: the “iron-regulated” bone morphogenetic protein (BMP) and the inflammatory JAK-STAT pathways. To obtain broader insights into cellular processes that modulate hep...

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Veröffentlicht in:	Blood 2014-03, Vol.123 (10), p.1574-1585
Hauptverfasser:	Mleczko-Sanecka, Katarzyna, Roche, Franziska, Rita da Silva, Ana, Call, Debora, D'Alessio, Flavia, Ragab, Anan, Lapinski, Philip E., Ummanni, Ramesh, Korf, Ulrike, Oakes, Christopher, Damm, Georg, D'Alessandro, Lorenza A., Klingmüller, Ursula, King, Philip D., Boutros, Michael, Hentze, Matthias W., Muckenthaler, Martina U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Morphogenetic Proteins - metabolism Cell Line Gene Expression Profiling Gene Expression Regulation Hepcidins - genetics Hepcidins - metabolism Humans Male Mice Mice, Knockout Mitogen-Activated Protein Kinases - metabolism Protein Binding Proto-Oncogene Proteins c-raf - metabolism Proto-Oncogene Proteins p21(ras) - metabolism Red Cells, Iron, and Erythropoiesis Reproducibility of Results Response Elements RNA Interference Signal Transduction TOR Serine-Threonine Kinases - metabolism Transcription, Genetic
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