Structure of the binding site for inositol phosphates in a PH domain

Phosphatidylinositol bisphosphate has been found to bind specifically to pleckstrin homology (PH) domains that are commonly present in signalling proteins but also found in cytoskeleton. We have studied the complexes of the beta‐spectrin PH domain and soluble inositol phosphates using both circular...

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Veröffentlicht in:	The EMBO journal 1995-10, Vol.14 (19), p.4676-4685
Hauptverfasser:	Hyvönen, M., Macias, M. J., Nilges, M., Oschkinat, H., Saraste, M., Wilmanns, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Blood Proteins - chemistry Cell Membrane - chemistry Circular Dichroism Crystallography, X-Ray Inositol Phosphates - metabolism Magnetic Resonance Spectroscopy Models, Molecular Molecular Sequence Data Phosphoproteins Protein Conformation Sequence Homology, Amino Acid Spectrin - chemistry Spectrin - metabolism
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