The structural repertoire of the human V kappa domain

In humans, the gene for the V kappa domain is produced by the recombination of one of 40 functional V kappa segments and one of five functional J kappa segments. We have analysed the sequences of these germline segments and of 736 rearranged V kappa genes to determine the repertoire of main chain co...

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Veröffentlicht in:	The EMBO journal 1995-09, Vol.14 (18), p.4628-4638
Hauptverfasser:	Tomlinson, I. M., Cox, J. P., Gherardi, E., Lesk, A. M., Chothia, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites, Antibody - genetics Binding Sites, Antibody - immunology Gene Rearrangement Genes, Immunoglobulin Germ Cells Humans Immunoglobulin Joining Region - chemistry Immunoglobulin Joining Region - genetics Immunoglobulin Joining Region - immunology Immunoglobulin kappa-Chains - chemistry Immunoglobulin kappa-Chains - genetics Immunoglobulin kappa-Chains - immunology Immunoglobulin Variable Region - chemistry Immunoglobulin Variable Region - genetics Immunoglobulin Variable Region - immunology Models, Molecular Molecular Sequence Data Mutation Protein Conformation Sequence Homology, Amino Acid Structure-Activity Relationship
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