Promyelocytic Leukemia Protein Interacts with the Apoptosis-associated Speck-like Protein to Limit Inflammasome Activation

The apoptosis-associated speck-like protein containing a caspase-activating recruitment domain (ASC) is an essential component of several inflammasomes, multiprotein complexes that regulate caspase-1 activation and inflammation. We report here an interaction between promyelocytic leukemia protein (P...

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Veröffentlicht in:	The Journal of biological chemistry 2014-03, Vol.289 (10), p.6429-6437
Hauptverfasser:	Dowling, Jennifer K., Becker, Christine E., Bourke, Nollaig M., Corr, Sinead C., Connolly, Dympna J., Quinn, Susan R., Pandolfi, Paolo P., Mansell, Ashley, O'Neill, Luke A.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer CARD Signaling Adaptor Proteins Carrier Proteins - metabolism Cell Line, Tumor Cell Nucleus - metabolism Cytokine Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Cytosol - metabolism DNA-Binding Proteins HEK293 Cells Humans Immunology Inflammasome Inflammasomes - metabolism Inflammation Innate Immunity Macrophages - metabolism NLR Family, Pyrin Domain-Containing 3 Protein Nod-like Receptors (NLR) Nuclear Proteins - genetics Nuclear Proteins - metabolism Promyelocytic Leukemia Protein Protein Multimerization Transcription Factors - genetics Transcription Factors - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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