A two-phased screening paradigm for evaluating candidate medications for cocaine cessation or relapse prevention: Modafinil, levodopa–carbidopa, naltrexone

Abstract Background Cocaine pharmacotherapy trials are often confounded by considerable variability in baseline cocaine-use levels, obscuring possible medication efficacy. Testing the feasibility of using a prerandomization, abstinence-induction protocol, we screened three candidate medications to e...

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Veröffentlicht in:	Drug and alcohol dependence 2014-03, Vol.136, p.100-107
Hauptverfasser:	Schmitz, Joy M, Green, Charles E, Stotts, Angela L, Lindsay, Jan A, Rathnayaka, Nuvan S, Grabowski, John, Moeller, F. Gerard
Format:	Artikel
Sprache:	eng
Schlagworte:	Abstinence Adolescent Adult Benzhydryl Compounds - adverse effects Benzhydryl Compounds - therapeutic use Candidates Carbidopa - adverse effects Carbidopa - therapeutic use Central Nervous System Stimulants - adverse effects Central Nervous System Stimulants - therapeutic use Cessation Cocaine Cocaine cessation Cocaine-Related Disorders - drug therapy Cocaine-Related Disorders - psychology Cocaine-Related Disorders - therapy Cognitive Behavioral Therapy Contingency management Data Interpretation, Statistical Diagnostic and Statistical Manual of Mental Disorders Dopamine Agents - adverse effects Dopamine Agents - therapeutic use Female Humans Levodopa Levodopa - adverse effects Levodopa - therapeutic use Male Middle Aged Modafinil Motivational Interviewing Naltrexone Naltrexone - adverse effects Naltrexone - therapeutic use Narcotic Antagonists - adverse effects Narcotic Antagonists - therapeutic use Neuropsychological Tests Patient Compliance Psychiatry Relapse prevention Secondary Prevention Treatment Outcome Young Adult
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