The Niacin/Butyrate Receptor GPR109A Suppresses Mammary Tumorigenesis by Inhibiting Cell Survival

GPR109A, a G-protein-coupled receptor, is activated by niacin and butyrate. Upon activation in colonocytes, GPR109A potentiates anti-inflammatory pathways, induces apoptosis, and protects against inflammation-induced colon cancer. In contrast, GPR109A activation in keratinocytes induces flushing by...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2014-02, Vol.74 (4), p.1166-1178
Hauptverfasser:	ELANGOVAN, Selvakumar, PATHANIA, Rajneesh, GANAPATHY, Vadivel, THANGARAJU, Muthusamy, RAMACHANDRAN, Sabarish, ANANTH, Sudha, PADIA, Ravi N, LING LAN, SINGH, Nagendra, MARTIN, Pamela M, HAWTHORN, Lesleyann, PRASAD, Puttur D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Breast Neoplasms - genetics Butyrates - metabolism Cell Survival - genetics Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Cells, Cultured Female Genes, Tumor Suppressor - physiology HEK293 Cells Humans MCF-7 Cells Medical sciences Mice Mice, Inbred BALB C Mice, Knockout Mice, Nude Niacin - metabolism Pharmacology. Drug treatments Receptors, G-Protein-Coupled - physiology Receptors, Nicotinic - physiology Tumors
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