Stochastic Fusion Simulations and Experiments Suggest Passive and Active Roles of Hemagglutinin during Membrane Fusion

Influenza enters the host cell cytoplasm by fusing the viral and host membrane together. Fusion is mediated by hemagglutinin (HA) trimers that undergo conformational change when acidified in the endosome. It is currently debated how many HA trimers, w, and how many conformationally changed HA trimer...

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Veröffentlicht in:	Biophysical journal 2014-02, Vol.106 (4), p.843-854
Hauptverfasser:	Lee, Donald W., Thapar, Vikram, Clancy, Paulette, Daniel, Susan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biophysics Biopolymers Cellular biology Correlation Cytoplasm Density Endosomes Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - metabolism Hydroxyapatite Influenza Lipid Bilayers - chemistry Lipid Bilayers - metabolism Membranes Models, Biological Protein Multimerization Stochastic Processes Stochasticity Trimers Virus Internalization
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