universally conserved region of the largest subunit participates in the active site of RNA polymerase III

The largest subunits of the three eukaryotic nuclear RNA polymerases present extensive sequence homology with the beta' subunit of the bacterial enzymes over five major co-linear regions. Region d is the most highly conserved and contains a motif, (Y/F)NADFDGD(E/Q)M(N/A), which is invariant in...

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Veröffentlicht in:	The EMBO journal 1995-08, Vol.14 (15), p.3766-3776
Hauptverfasser:	Dieci, G, Hermann-Le Denmat, S, Lukhtanov, E, Thuriaux, P, Werner, M, Sentenac, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Amino Acid Sequence amino acid sequences Base Sequence Binding Sites Conserved Sequence - genetics DNA, Fungal - metabolism DNA-directed RNA polymerase enzyme activity Kinetics messenger RNA Molecular Sequence Data mutagenesis mutants Mutation RNA Polymerase III - genetics RNA Polymerase III - isolation & purification RNA Polymerase III - metabolism RNA, Fungal - biosynthesis RNA, Transfer - genetics Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Sequence Alignment transcript elongation transcription (genetics) Transcription Factor TFIIIB Transcription Factors - metabolism Transcription Factors, TFIII Transcription, Genetic - genetics Uridine Triphosphate - metabolism
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