TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain

New evidence indicates the involvement of protein degradation dysfunctions in neurodegeneration, innate immunity response and alcohol hepatotoxicity. We recently demonstrated that ethanol increases brain proinflammatory mediators and causes brain damage by activating Toll-like receptor 4 (TLR4) sign...

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Veröffentlicht in:	Cell death & disease 2014-02, Vol.5 (2), p.e1066-e1066
Hauptverfasser:	Pla, A, Pascual, M, Renau-Piqueras, J, Guerri, C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/262 631/80/304 631/80/82/39 692/699/375/1345 Animals Antibodies Autophagy - drug effects Autophagy-Related Protein 12 Autophagy-Related Protein 5 Biochemistry Biomedical and Life Sciences Cathepsin B - metabolism Cell Biology Cell Culture Cerebral Cortex - drug effects Cerebral Cortex - enzymology Cerebral Cortex - immunology Cerebral Cortex - pathology Ethanol - toxicity Immunology Life Sciences Lysosomes - drug effects Lysosomes - enzymology Lysosomes - immunology Lysosomes - pathology Male Mice Mice, Inbred C57BL Mice, Knockout Microtubule-Associated Proteins - metabolism Original original-article Phosphorylation Proteasome Endopeptidase Complex - immunology Proteasome Endopeptidase Complex - metabolism Proteasome Inhibitors - pharmacology Protein Kinase Inhibitors - pharmacology Proteins - metabolism Signal Transduction - drug effects Time Factors Toll-Like Receptor 4 - deficiency Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism TOR Serine-Threonine Kinases - antagonists & inhibitors Transcription Factor TFIIH Transcription Factors - metabolism Ubiquitination
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