Detailed analysis of the IL‐5‐IL‐5R alpha interaction: characterization of crucial residues on the ligand and the receptor

The receptor for interleukin‐5 (IL‐5) is composed of two different subunits. The IL‐5 receptor alpha (IL‐5R alpha) is required for ligand‐specific binding while association with the beta‐chain results in increased binding affinity. Murine IL‐5 (mIL‐5) has similar activity on human and murine cells,...

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Veröffentlicht in:	The EMBO journal 1995-07, Vol.14 (14), p.3395-3402
Hauptverfasser:	Cornelis, S., Plaetinck, G., Devos, R., Van der Heyden, J., Tavernier, J., Sanderson, C.J., Guisez, Y., Fiers, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acids - analysis Animals Base Sequence DNA Primers Growth Hormone - chemistry Humans Interleukin-5 - chemistry Interleukin-5 - genetics Interleukin-5 - metabolism Ligands Mice Molecular Sequence Data Mutagenesis, Site-Directed Receptors, Interleukin - chemistry Receptors, Interleukin - genetics Receptors, Interleukin - metabolism Receptors, Interleukin-5 Receptors, Somatotropin - chemistry Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Sequence Homology, Amino Acid Species Specificity Structure-Activity Relationship
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