Female dietary antioxidant intake and time to pregnancy among couples treated for unexplained infertility
Objective To determine whether increased antioxidant intake in women is associated with shorter time to pregnancy (TTP) among a cohort of couples being treated for unexplained infertility. Design Secondary data analysis of a randomized controlled trial. Setting Academic medical center associated wit...
Gespeichert in:
| Veröffentlicht in: | Fertility and sterility 2014-03, Vol.101 (3), p.759-766 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 766 |
|---|---|
| container_issue | 3 |
| container_start_page | 759 |
| container_title | Fertility and sterility |
| container_volume | 101 |
| creator | Ruder, Elizabeth H., Ph.D., M.P.H Hartman, Terryl J., Ph.D., M.P.H Reindollar, Richard H., M.D Goldman, Marlene B., Sc.D |
| description | Objective To determine whether increased antioxidant intake in women is associated with shorter time to pregnancy (TTP) among a cohort of couples being treated for unexplained infertility. Design Secondary data analysis of a randomized controlled trial. Setting Academic medical center associated with a private infertility center. Patients Females with unexplained infertility. Interventions None. Main Outcome Measure(s) The time it took to establish a pregnancy that led to a live birth. Result(s) Mean nutrient intake exceeded the estimated average requirement (EAR) for vitamins C and E. No differences in mean intake of any of the antioxidants were noted between women who delivered a live-born infant during the study period vs. those who did not. In multivariable models, intake of β-carotene from dietary supplements was associated with shorter TTP among women with body mass index (BMI) ≥25 kg/m2 (hazard ratio [HR] 1.29, 95% confidence interval [CI] 1.09–1.53) and women |
| doi_str_mv | 10.1016/j.fertnstert.2013.11.008 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3943921</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0015028213032615</els_id><sourcerecordid>S0015028213032615</sourcerecordid><originalsourceid>FETCH-LOGICAL-c534t-4c866f5d253a65d5a55fe75ea526b55fb1288edd49c51ad84df1bfeee5dfa1a23</originalsourceid><addsrcrecordid>eNqNkt9vFCEQx4nR2LP6Lxj-gVsZ2NnuvTTRxmqTJj6oz4SD2ZPrLmyAa3r_vWzO1h9PvjAMzPc78MkwxkE0IKB7t28GSiXkUtdGClANQCNE_4ytALFbY4fqOVsJAbgWspdn7FXOeyFEBxfyJTuTrUIUKFbMX9NkRuLOUzHpyE0oPj54VyP3oZg7qkeOFz8RL5HPiXbBBFsLpxh23MbDPFLmJZEp5PgQEz8EephH40PNfVge6kdfjq_Zi8GMmd78iufs-_XHb1ef17dfPt1cvb9dW1RtWbe277oBnURlOnRoEAe6QDIou23db0H2PTnXbiyCcX3rBtgORIRuMGCkOmeXJ9_5sJ3IWQolmVHPyU_1gzoar_--Cf6H3sV7rTat2kioBv3JwKaYc6LhSQtCL_j1Xv_Grxf8GkBX_FX69s_eT8JH3rXgw6mAKoF7T0ln6ylYcj6RLdpF_z9dLv8xsaMP3prxjo6U9_GQQiWsQWephf66jMEyBaCEkh2g-gmAqrYW</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Female dietary antioxidant intake and time to pregnancy among couples treated for unexplained infertility</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Ruder, Elizabeth H., Ph.D., M.P.H ; Hartman, Terryl J., Ph.D., M.P.H ; Reindollar, Richard H., M.D ; Goldman, Marlene B., Sc.D</creator><creatorcontrib>Ruder, Elizabeth H., Ph.D., M.P.H ; Hartman, Terryl J., Ph.D., M.P.H ; Reindollar, Richard H., M.D ; Goldman, Marlene B., Sc.D</creatorcontrib><description>Objective To determine whether increased antioxidant intake in women is associated with shorter time to pregnancy (TTP) among a cohort of couples being treated for unexplained infertility. Design Secondary data analysis of a randomized controlled trial. Setting Academic medical center associated with a private infertility center. Patients Females with unexplained infertility. Interventions None. Main Outcome Measure(s) The time it took to establish a pregnancy that led to a live birth. Result(s) Mean nutrient intake exceeded the estimated average requirement (EAR) for vitamins C and E. No differences in mean intake of any of the antioxidants were noted between women who delivered a live-born infant during the study period vs. those who did not. In multivariable models, intake of β-carotene from dietary supplements was associated with shorter TTP among women with body mass index (BMI) ≥25 kg/m2 (hazard ratio [HR] 1.29, 95% confidence interval [CI] 1.09–1.53) and women <35 y (HR 1.19, 95% CI 1.01–1.41). Intake of vitamin C from dietary supplements was associated with shorter TTP among women with BMI <25 kg/m2 (HR 1.09, 95% CI 1.03–1.15) and women <35 y (HR 1.10, 95% CI 1.02–1.18). Intake of vitamin E from dietary supplements among women ≥35 y also was associated with shorter TTP (HR 1.07, 95% CI 1.01–1.13). Conclusion(s) Shorter TTP was observed among women with BMI <25 kg/m2 with increasing vitamin C, women with BMI ≥25 kg/m2 with increasing β-carotene, women <35 y with increasing β-carotene and vitamin C, and women ≥35 y with increasing vitamin E. Clinical Trial Registration Number NCT00260091.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2013.11.008</identifier><identifier>PMID: 24355050</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; antioxidants ; Antioxidants - administration & dosage ; Cohort Studies ; Diet ; Dietary Supplements ; Female ; Humans ; Infertility, Female - drug therapy ; Infertility, Female - epidemiology ; Internal Medicine ; Live Birth - epidemiology ; Male ; Middle Aged ; nutritional epidemiology ; Obstetrics and Gynecology ; oxidative stress ; Pregnancy ; Prospective Studies ; Time-to-Pregnancy - drug effects ; Time-to-Pregnancy - physiology ; Treatment Outcome ; unexplained infertility ; Young Adult</subject><ispartof>Fertility and sterility, 2014-03, Vol.101 (3), p.759-766</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2014 American Society for Reproductive Medicine</rights><rights>Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><rights>2013 Published by Elsevier Inc on behalf of American Society for Reproductive Medicine. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-4c866f5d253a65d5a55fe75ea526b55fb1288edd49c51ad84df1bfeee5dfa1a23</citedby><cites>FETCH-LOGICAL-c534t-4c866f5d253a65d5a55fe75ea526b55fb1288edd49c51ad84df1bfeee5dfa1a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fertnstert.2013.11.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24355050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruder, Elizabeth H., Ph.D., M.P.H</creatorcontrib><creatorcontrib>Hartman, Terryl J., Ph.D., M.P.H</creatorcontrib><creatorcontrib>Reindollar, Richard H., M.D</creatorcontrib><creatorcontrib>Goldman, Marlene B., Sc.D</creatorcontrib><title>Female dietary antioxidant intake and time to pregnancy among couples treated for unexplained infertility</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To determine whether increased antioxidant intake in women is associated with shorter time to pregnancy (TTP) among a cohort of couples being treated for unexplained infertility. Design Secondary data analysis of a randomized controlled trial. Setting Academic medical center associated with a private infertility center. Patients Females with unexplained infertility. Interventions None. Main Outcome Measure(s) The time it took to establish a pregnancy that led to a live birth. Result(s) Mean nutrient intake exceeded the estimated average requirement (EAR) for vitamins C and E. No differences in mean intake of any of the antioxidants were noted between women who delivered a live-born infant during the study period vs. those who did not. In multivariable models, intake of β-carotene from dietary supplements was associated with shorter TTP among women with body mass index (BMI) ≥25 kg/m2 (hazard ratio [HR] 1.29, 95% confidence interval [CI] 1.09–1.53) and women <35 y (HR 1.19, 95% CI 1.01–1.41). Intake of vitamin C from dietary supplements was associated with shorter TTP among women with BMI <25 kg/m2 (HR 1.09, 95% CI 1.03–1.15) and women <35 y (HR 1.10, 95% CI 1.02–1.18). Intake of vitamin E from dietary supplements among women ≥35 y also was associated with shorter TTP (HR 1.07, 95% CI 1.01–1.13). Conclusion(s) Shorter TTP was observed among women with BMI <25 kg/m2 with increasing vitamin C, women with BMI ≥25 kg/m2 with increasing β-carotene, women <35 y with increasing β-carotene and vitamin C, and women ≥35 y with increasing vitamin E. Clinical Trial Registration Number NCT00260091.</description><subject>Adult</subject><subject>antioxidants</subject><subject>Antioxidants - administration & dosage</subject><subject>Cohort Studies</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>Humans</subject><subject>Infertility, Female - drug therapy</subject><subject>Infertility, Female - epidemiology</subject><subject>Internal Medicine</subject><subject>Live Birth - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>nutritional epidemiology</subject><subject>Obstetrics and Gynecology</subject><subject>oxidative stress</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Time-to-Pregnancy - drug effects</subject><subject>Time-to-Pregnancy - physiology</subject><subject>Treatment Outcome</subject><subject>unexplained infertility</subject><subject>Young Adult</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkt9vFCEQx4nR2LP6Lxj-gVsZ2NnuvTTRxmqTJj6oz4SD2ZPrLmyAa3r_vWzO1h9PvjAMzPc78MkwxkE0IKB7t28GSiXkUtdGClANQCNE_4ytALFbY4fqOVsJAbgWspdn7FXOeyFEBxfyJTuTrUIUKFbMX9NkRuLOUzHpyE0oPj54VyP3oZg7qkeOFz8RL5HPiXbBBFsLpxh23MbDPFLmJZEp5PgQEz8EephH40PNfVge6kdfjq_Zi8GMmd78iufs-_XHb1ef17dfPt1cvb9dW1RtWbe277oBnURlOnRoEAe6QDIou23db0H2PTnXbiyCcX3rBtgORIRuMGCkOmeXJ9_5sJ3IWQolmVHPyU_1gzoar_--Cf6H3sV7rTat2kioBv3JwKaYc6LhSQtCL_j1Xv_Grxf8GkBX_FX69s_eT8JH3rXgw6mAKoF7T0ln6ylYcj6RLdpF_z9dLv8xsaMP3prxjo6U9_GQQiWsQWephf66jMEyBaCEkh2g-gmAqrYW</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Ruder, Elizabeth H., Ph.D., M.P.H</creator><creator>Hartman, Terryl J., Ph.D., M.P.H</creator><creator>Reindollar, Richard H., M.D</creator><creator>Goldman, Marlene B., Sc.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20140301</creationdate><title>Female dietary antioxidant intake and time to pregnancy among couples treated for unexplained infertility</title><author>Ruder, Elizabeth H., Ph.D., M.P.H ; Hartman, Terryl J., Ph.D., M.P.H ; Reindollar, Richard H., M.D ; Goldman, Marlene B., Sc.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-4c866f5d253a65d5a55fe75ea526b55fb1288edd49c51ad84df1bfeee5dfa1a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>antioxidants</topic><topic>Antioxidants - administration & dosage</topic><topic>Cohort Studies</topic><topic>Diet</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>Humans</topic><topic>Infertility, Female - drug therapy</topic><topic>Infertility, Female - epidemiology</topic><topic>Internal Medicine</topic><topic>Live Birth - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>nutritional epidemiology</topic><topic>Obstetrics and Gynecology</topic><topic>oxidative stress</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Time-to-Pregnancy - drug effects</topic><topic>Time-to-Pregnancy - physiology</topic><topic>Treatment Outcome</topic><topic>unexplained infertility</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruder, Elizabeth H., Ph.D., M.P.H</creatorcontrib><creatorcontrib>Hartman, Terryl J., Ph.D., M.P.H</creatorcontrib><creatorcontrib>Reindollar, Richard H., M.D</creatorcontrib><creatorcontrib>Goldman, Marlene B., Sc.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruder, Elizabeth H., Ph.D., M.P.H</au><au>Hartman, Terryl J., Ph.D., M.P.H</au><au>Reindollar, Richard H., M.D</au><au>Goldman, Marlene B., Sc.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Female dietary antioxidant intake and time to pregnancy among couples treated for unexplained infertility</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>101</volume><issue>3</issue><spage>759</spage><epage>766</epage><pages>759-766</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><abstract>Objective To determine whether increased antioxidant intake in women is associated with shorter time to pregnancy (TTP) among a cohort of couples being treated for unexplained infertility. Design Secondary data analysis of a randomized controlled trial. Setting Academic medical center associated with a private infertility center. Patients Females with unexplained infertility. Interventions None. Main Outcome Measure(s) The time it took to establish a pregnancy that led to a live birth. Result(s) Mean nutrient intake exceeded the estimated average requirement (EAR) for vitamins C and E. No differences in mean intake of any of the antioxidants were noted between women who delivered a live-born infant during the study period vs. those who did not. In multivariable models, intake of β-carotene from dietary supplements was associated with shorter TTP among women with body mass index (BMI) ≥25 kg/m2 (hazard ratio [HR] 1.29, 95% confidence interval [CI] 1.09–1.53) and women <35 y (HR 1.19, 95% CI 1.01–1.41). Intake of vitamin C from dietary supplements was associated with shorter TTP among women with BMI <25 kg/m2 (HR 1.09, 95% CI 1.03–1.15) and women <35 y (HR 1.10, 95% CI 1.02–1.18). Intake of vitamin E from dietary supplements among women ≥35 y also was associated with shorter TTP (HR 1.07, 95% CI 1.01–1.13). Conclusion(s) Shorter TTP was observed among women with BMI <25 kg/m2 with increasing vitamin C, women with BMI ≥25 kg/m2 with increasing β-carotene, women <35 y with increasing β-carotene and vitamin C, and women ≥35 y with increasing vitamin E. Clinical Trial Registration Number NCT00260091.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24355050</pmid><doi>10.1016/j.fertnstert.2013.11.008</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0015-0282 |
| ispartof | Fertility and sterility, 2014-03, Vol.101 (3), p.759-766 |
| issn | 0015-0282 1556-5653 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3943921 |
| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult antioxidants Antioxidants - administration & dosage Cohort Studies Diet Dietary Supplements Female Humans Infertility, Female - drug therapy Infertility, Female - epidemiology Internal Medicine Live Birth - epidemiology Male Middle Aged nutritional epidemiology Obstetrics and Gynecology oxidative stress Pregnancy Prospective Studies Time-to-Pregnancy - drug effects Time-to-Pregnancy - physiology Treatment Outcome unexplained infertility Young Adult |
| title | Female dietary antioxidant intake and time to pregnancy among couples treated for unexplained infertility |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T16%3A39%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Female%20dietary%20antioxidant%20intake%20and%20time%20to%20pregnancy%20among%20couples%20treated%20for%20unexplained%20infertility&rft.jtitle=Fertility%20and%20sterility&rft.au=Ruder,%20Elizabeth%20H.,%20Ph.D.,%20M.P.H&rft.date=2014-03-01&rft.volume=101&rft.issue=3&rft.spage=759&rft.epage=766&rft.pages=759-766&rft.issn=0015-0282&rft.eissn=1556-5653&rft_id=info:doi/10.1016/j.fertnstert.2013.11.008&rft_dat=%3Celsevier_pubme%3ES0015028213032615%3C/elsevier_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/24355050&rft_els_id=S0015028213032615&rfr_iscdi=true |