Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling

Duchenne muscular dystrophy (DMD) is caused by a lack of the dystrophin protein and has no effective treatment at present. Zebrafish provide a powerful in vivo tool for high-throughput therapeutic drug screening for the improvement of muscle phenotypes caused by dystrophin deficiency. Using the dyst...

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Veröffentlicht in:	Human molecular genetics 2014-04, Vol.23 (7), p.1869-1878
Hauptverfasser:	Kawahara, Genri, Gasperini, Molly J, Myers, Jennifer A, Widrick, Jeffrey J, Eran, Alal, Serafini, Peter R, Alexander, Matthew S, Pletcher, Mathew T, Morris, Carl A, Kunkel, Louis M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclic GMP - biosynthesis Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism Danio rerio Disease Models, Animal Drug Evaluation, Preclinical Dystrophin - deficiency Dystrophin - genetics Freshwater Heme Oxygenase-1 - biosynthesis Heme Oxygenase-1 - genetics Mice Mice, Inbred C57BL Mice, Transgenic Muscular Dystrophy, Duchenne - drug therapy Phosphodiesterase 5 Inhibitors - pharmacology Piperazines - pharmacology Purines - pharmacology RNA, Messenger - genetics Signal Transduction - genetics Sildenafil Citrate Sulfones - pharmacology Up-Regulation Zebrafish - genetics
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