Functional roles for evolutionarily conserved Spt4p at centromeres and heterochromatin in Saccharomyces cerevisiae

The kinetochore (centromeric DNA and associated proteins) mediates the attachment of chromosomes to the mitotic spindle apparatus and is required for faithful chromosome transmission. We established that evolutionarily conserved Saccharomyces cerevisiae SPT4 , previously identified in genetic screen...

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Veröffentlicht in:	The EMBO journal 2004-04, Vol.23 (8), p.1804-1814
Hauptverfasser:	Crotti, L.B, Basrai, M.A
Format:	Artikel
Sprache:	eng
Schlagworte:	binding capacity Centromere - genetics Centromere - metabolism centromeres Chromatin - genetics Chromatin - metabolism Chromosomal Proteins, Non-Histone Chromosomes Chromosomes, Fungal - genetics Chromosomes, Fungal - metabolism Conserved Sequence CSE4 Deoxyribonucleic acid DNA DNA, Fungal - genetics DNA, Fungal - metabolism DNA-binding proteins DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism EMBO09 EMBO13 Evolution, Molecular Gene Silencing heterochromatin Heterochromatin - genetics Heterochromatin - metabolism Humans kinetochore kinetochore proteins kinetochores Kinetochores - metabolism loci Mammals mutants Mutation - genetics Nuclear Proteins - genetics Nuclear Proteins - metabolism Phenotype Protein Binding Proteins Repressor Proteins - genetics Repressor Proteins - metabolism S. cerevisiae Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism silencing Silent Information Regulator Proteins, Saccharomyces cerevisiae - genetics Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism SPT4 transcription (genetics) Transcriptional Elongation Factors - genetics Transcriptional Elongation Factors - metabolism Yeasts
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