Inflammatory consequences in a rodent model of mild traumatic brain injury
Mild traumatic brain injury (mTBI), particularly mild "blast type" injuries resulting from improvised exploding devices and many sport-caused injuries to the brain, result in long-term impairment of cognition and behavior. Our central hypothesis is that there are inflammatory consequences...
Gespeichert in:
| Veröffentlicht in: | Journal of neurotrauma 2013-05, Vol.30 (9), p.727-740 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 740 |
|---|---|
| container_issue | 9 |
| container_start_page | 727 |
| container_title | Journal of neurotrauma |
| container_volume | 30 |
| creator | Perez-Polo, J Regino Rea, Harriet C Johnson, Kathia M Parsley, Margaret A Unabia, Geda C Xu, Guojing Infante, Smitha K Dewitt, Douglas S Hulsebosch, Claire E |
| description | Mild traumatic brain injury (mTBI), particularly mild "blast type" injuries resulting from improvised exploding devices and many sport-caused injuries to the brain, result in long-term impairment of cognition and behavior. Our central hypothesis is that there are inflammatory consequences to mTBI that persist over time and, in part, are responsible for resultant pathogenesis and clinical outcomes. We used an adaptation (1 atmosphere pressure) of a well-characterized moderate-to-severe brain lateral fluid percussion (LFP) brain injury rat model. Our mild LFP injury resulted in acute increases in interleukin-1α/β and tumor necrosis factor alpha levels, macrophage/microglial and astrocytic activation, evidence of heightened cellular stress, and blood-brain barrier (BBB) dysfunction that were evident as early as 3-6 h postinjury. Both glial activation and BBB dysfunction persisted for 18 days postinjury. |
| doi_str_mv | 10.1089/neu.2012.2650 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3941841</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2992513691</sourcerecordid><originalsourceid>FETCH-LOGICAL-p191t-d24b646917ec2643bf70f89c835f66bc967d97d4e884464a1de068530f84e0be3</originalsourceid><addsrcrecordid>eNpVUElLAzEYDaLYWj16lYDnqdmXiyDFlYIXPYdMktEpM0nNzAj99wasoqd3eMv3vgfAOUZLjJS-imFaEoTJkgiODsAccy4rjRg5BPPCy0pijmfgZBg2CGEqiDwGM0KpQMU1B0-Psels39sx5R10KQ7hYwrRhQG2EVqYkw9xhH2BDqYG9m3n4ZjtVBytg3W2RdbGzZR3p-Cosd0Qzva4AK93ty-rh2r9fP-4ullXW6zxWHnCasGExjI4IhitG4kapZ2ivBGidlpIr6VnQSnGBLPYByQUp0XEAqoDXYDr79ztVPfBu9Iv285sc9vbvDPJtuY_E9t385Y-DdUMK4ZLwOU-IKfy7DCaTZpyLJ1NGUhQrhBiRXXx98xv_s929AtE_3Fj</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1366358004</pqid></control><display><type>article</type><title>Inflammatory consequences in a rodent model of mild traumatic brain injury</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Perez-Polo, J Regino ; Rea, Harriet C ; Johnson, Kathia M ; Parsley, Margaret A ; Unabia, Geda C ; Xu, Guojing ; Infante, Smitha K ; Dewitt, Douglas S ; Hulsebosch, Claire E</creator><creatorcontrib>Perez-Polo, J Regino ; Rea, Harriet C ; Johnson, Kathia M ; Parsley, Margaret A ; Unabia, Geda C ; Xu, Guojing ; Infante, Smitha K ; Dewitt, Douglas S ; Hulsebosch, Claire E</creatorcontrib><description>Mild traumatic brain injury (mTBI), particularly mild "blast type" injuries resulting from improvised exploding devices and many sport-caused injuries to the brain, result in long-term impairment of cognition and behavior. Our central hypothesis is that there are inflammatory consequences to mTBI that persist over time and, in part, are responsible for resultant pathogenesis and clinical outcomes. We used an adaptation (1 atmosphere pressure) of a well-characterized moderate-to-severe brain lateral fluid percussion (LFP) brain injury rat model. Our mild LFP injury resulted in acute increases in interleukin-1α/β and tumor necrosis factor alpha levels, macrophage/microglial and astrocytic activation, evidence of heightened cellular stress, and blood-brain barrier (BBB) dysfunction that were evident as early as 3-6 h postinjury. Both glial activation and BBB dysfunction persisted for 18 days postinjury.</description><identifier>ISSN: 0897-7151</identifier><identifier>EISSN: 1557-9042</identifier><identifier>DOI: 10.1089/neu.2012.2650</identifier><identifier>PMID: 23360201</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Animals ; Blood-brain barrier ; Blood-Brain Barrier - pathology ; Brain - pathology ; Brain Concussion - complications ; Brain Concussion - pathology ; Brain damage ; Cellular biology ; Cytokines ; Cytokines - analysis ; Cytokines - biosynthesis ; Disease Models, Animal ; Head injuries ; Immunoassay ; Inflammation - etiology ; Inflammation - pathology ; Male ; Microscopy, Confocal ; Motor Activity - physiology ; Original ; Rats ; Rats, Sprague-Dawley ; Rodents</subject><ispartof>Journal of neurotrauma, 2013-05, Vol.30 (9), p.727-740</ispartof><rights>(©) Copyright 2013, Mary Ann Liebert, Inc.</rights><rights>Copyright 2013, Mary Ann Liebert, Inc. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23360201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perez-Polo, J Regino</creatorcontrib><creatorcontrib>Rea, Harriet C</creatorcontrib><creatorcontrib>Johnson, Kathia M</creatorcontrib><creatorcontrib>Parsley, Margaret A</creatorcontrib><creatorcontrib>Unabia, Geda C</creatorcontrib><creatorcontrib>Xu, Guojing</creatorcontrib><creatorcontrib>Infante, Smitha K</creatorcontrib><creatorcontrib>Dewitt, Douglas S</creatorcontrib><creatorcontrib>Hulsebosch, Claire E</creatorcontrib><title>Inflammatory consequences in a rodent model of mild traumatic brain injury</title><title>Journal of neurotrauma</title><addtitle>J Neurotrauma</addtitle><description>Mild traumatic brain injury (mTBI), particularly mild "blast type" injuries resulting from improvised exploding devices and many sport-caused injuries to the brain, result in long-term impairment of cognition and behavior. Our central hypothesis is that there are inflammatory consequences to mTBI that persist over time and, in part, are responsible for resultant pathogenesis and clinical outcomes. We used an adaptation (1 atmosphere pressure) of a well-characterized moderate-to-severe brain lateral fluid percussion (LFP) brain injury rat model. Our mild LFP injury resulted in acute increases in interleukin-1α/β and tumor necrosis factor alpha levels, macrophage/microglial and astrocytic activation, evidence of heightened cellular stress, and blood-brain barrier (BBB) dysfunction that were evident as early as 3-6 h postinjury. Both glial activation and BBB dysfunction persisted for 18 days postinjury.</description><subject>Animals</subject><subject>Blood-brain barrier</subject><subject>Blood-Brain Barrier - pathology</subject><subject>Brain - pathology</subject><subject>Brain Concussion - complications</subject><subject>Brain Concussion - pathology</subject><subject>Brain damage</subject><subject>Cellular biology</subject><subject>Cytokines</subject><subject>Cytokines - analysis</subject><subject>Cytokines - biosynthesis</subject><subject>Disease Models, Animal</subject><subject>Head injuries</subject><subject>Immunoassay</subject><subject>Inflammation - etiology</subject><subject>Inflammation - pathology</subject><subject>Male</subject><subject>Microscopy, Confocal</subject><subject>Motor Activity - physiology</subject><subject>Original</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><issn>0897-7151</issn><issn>1557-9042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpVUElLAzEYDaLYWj16lYDnqdmXiyDFlYIXPYdMktEpM0nNzAj99wasoqd3eMv3vgfAOUZLjJS-imFaEoTJkgiODsAccy4rjRg5BPPCy0pijmfgZBg2CGEqiDwGM0KpQMU1B0-Psels39sx5R10KQ7hYwrRhQG2EVqYkw9xhH2BDqYG9m3n4ZjtVBytg3W2RdbGzZR3p-Cosd0Qzva4AK93ty-rh2r9fP-4ullXW6zxWHnCasGExjI4IhitG4kapZ2ivBGidlpIr6VnQSnGBLPYByQUp0XEAqoDXYDr79ztVPfBu9Iv285sc9vbvDPJtuY_E9t385Y-DdUMK4ZLwOU-IKfy7DCaTZpyLJ1NGUhQrhBiRXXx98xv_s929AtE_3Fj</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Perez-Polo, J Regino</creator><creator>Rea, Harriet C</creator><creator>Johnson, Kathia M</creator><creator>Parsley, Margaret A</creator><creator>Unabia, Geda C</creator><creator>Xu, Guojing</creator><creator>Infante, Smitha K</creator><creator>Dewitt, Douglas S</creator><creator>Hulsebosch, Claire E</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20130501</creationdate><title>Inflammatory consequences in a rodent model of mild traumatic brain injury</title><author>Perez-Polo, J Regino ; Rea, Harriet C ; Johnson, Kathia M ; Parsley, Margaret A ; Unabia, Geda C ; Xu, Guojing ; Infante, Smitha K ; Dewitt, Douglas S ; Hulsebosch, Claire E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p191t-d24b646917ec2643bf70f89c835f66bc967d97d4e884464a1de068530f84e0be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Blood-brain barrier</topic><topic>Blood-Brain Barrier - pathology</topic><topic>Brain - pathology</topic><topic>Brain Concussion - complications</topic><topic>Brain Concussion - pathology</topic><topic>Brain damage</topic><topic>Cellular biology</topic><topic>Cytokines</topic><topic>Cytokines - analysis</topic><topic>Cytokines - biosynthesis</topic><topic>Disease Models, Animal</topic><topic>Head injuries</topic><topic>Immunoassay</topic><topic>Inflammation - etiology</topic><topic>Inflammation - pathology</topic><topic>Male</topic><topic>Microscopy, Confocal</topic><topic>Motor Activity - physiology</topic><topic>Original</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perez-Polo, J Regino</creatorcontrib><creatorcontrib>Rea, Harriet C</creatorcontrib><creatorcontrib>Johnson, Kathia M</creatorcontrib><creatorcontrib>Parsley, Margaret A</creatorcontrib><creatorcontrib>Unabia, Geda C</creatorcontrib><creatorcontrib>Xu, Guojing</creatorcontrib><creatorcontrib>Infante, Smitha K</creatorcontrib><creatorcontrib>Dewitt, Douglas S</creatorcontrib><creatorcontrib>Hulsebosch, Claire E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database (ProQuest)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurotrauma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perez-Polo, J Regino</au><au>Rea, Harriet C</au><au>Johnson, Kathia M</au><au>Parsley, Margaret A</au><au>Unabia, Geda C</au><au>Xu, Guojing</au><au>Infante, Smitha K</au><au>Dewitt, Douglas S</au><au>Hulsebosch, Claire E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammatory consequences in a rodent model of mild traumatic brain injury</atitle><jtitle>Journal of neurotrauma</jtitle><addtitle>J Neurotrauma</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>30</volume><issue>9</issue><spage>727</spage><epage>740</epage><pages>727-740</pages><issn>0897-7151</issn><eissn>1557-9042</eissn><abstract>Mild traumatic brain injury (mTBI), particularly mild "blast type" injuries resulting from improvised exploding devices and many sport-caused injuries to the brain, result in long-term impairment of cognition and behavior. Our central hypothesis is that there are inflammatory consequences to mTBI that persist over time and, in part, are responsible for resultant pathogenesis and clinical outcomes. We used an adaptation (1 atmosphere pressure) of a well-characterized moderate-to-severe brain lateral fluid percussion (LFP) brain injury rat model. Our mild LFP injury resulted in acute increases in interleukin-1α/β and tumor necrosis factor alpha levels, macrophage/microglial and astrocytic activation, evidence of heightened cellular stress, and blood-brain barrier (BBB) dysfunction that were evident as early as 3-6 h postinjury. Both glial activation and BBB dysfunction persisted for 18 days postinjury.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>23360201</pmid><doi>10.1089/neu.2012.2650</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0897-7151 |
| ispartof | Journal of neurotrauma, 2013-05, Vol.30 (9), p.727-740 |
| issn | 0897-7151 1557-9042 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3941841 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Blood-brain barrier Blood-Brain Barrier - pathology Brain - pathology Brain Concussion - complications Brain Concussion - pathology Brain damage Cellular biology Cytokines Cytokines - analysis Cytokines - biosynthesis Disease Models, Animal Head injuries Immunoassay Inflammation - etiology Inflammation - pathology Male Microscopy, Confocal Motor Activity - physiology Original Rats Rats, Sprague-Dawley Rodents |
| title | Inflammatory consequences in a rodent model of mild traumatic brain injury |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T21%3A31%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inflammatory%20consequences%20in%20a%20rodent%20model%20of%20mild%20traumatic%20brain%20injury&rft.jtitle=Journal%20of%20neurotrauma&rft.au=Perez-Polo,%20J%20Regino&rft.date=2013-05-01&rft.volume=30&rft.issue=9&rft.spage=727&rft.epage=740&rft.pages=727-740&rft.issn=0897-7151&rft.eissn=1557-9042&rft_id=info:doi/10.1089/neu.2012.2650&rft_dat=%3Cproquest_pubme%3E2992513691%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1366358004&rft_id=info:pmid/23360201&rfr_iscdi=true |