Phenotypes and functions of persistent Sendai virus-induced antibody forming cells and CD8+ T cells in diffuse nasal-associated lymphoid tissue typify lymphocyte responses of the gut

Abstract Lymphocytes of the diffuse nasal-associated lymphoid tissue (d-NALT) are uniquely positioned to tackle respiratory pathogens at their point-of-entry, yet are rarely examined after intranasal (i.n.) vaccinations or infections. Here we evaluate an i.n. inoculation with Sendai virus (SeV) for...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2011-02, Vol.410 (2), p.429-436
Hauptverfasser:	Rudraraju, Rajeev, Surman, Sherri, Jones, Bart, Sealy, Robert, Woodland, David L, Hurwitz, Julia L
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation marker Animals Antibody forming cell B-Lymphocytes - immunology CD8+ T cell CD8-Positive T-Lymphocytes - immunology Cytokines - biosynthesis Cytolytic Disease Models, Animal Durability Female Gastrointestinal Tract - immunology Gastrointestinal Tract - virology Homing marker Immunoglobulin A - biosynthesis Immunoglobulin G - biosynthesis Infectious Disease Lymphoid Tissue - immunology Lymphoid Tissue - virology Mice Mice, Inbred C57BL Nasal associated lymphoid tissue Nasal Mucosa - immunology Nasal Mucosa - virology Protection Respirovirus Infections - immunology Respirovirus Infections - pathology Respirovirus Infections - virology Sendai virus - immunology T-Lymphocytes, Cytotoxic - immunology Tetramer Time Factors Vaccination
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