Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production

Spinal muscular atrophy (SMA) is a genetic disorder caused by the deletion of the survival motor neuron 1 (SMN1) gene that leads to loss of motor neurons in the spinal cord. Although motor neurons are selectively lost during SMA pathology, selective replacement of SMN in motor neurons does not lead...

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Veröffentlicht in:	Glia 2013-09, Vol.61 (9), p.1418-1428
Hauptverfasser:	McGivern, Jered V., Patitucci, Teresa N., Nord, Joshua A., Barabas, Marie-Elizabeth A., Stucky, Cheryl L., Ebert, Allison D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Age Factors Aldehyde Dehydrogenase - metabolism Amyotrophic lateral sclerosis Analysis of Variance Animals Animals, Newborn astrocyte activation Astrocytes - drug effects Astrocytes - metabolism ATP Calcium Calcium - metabolism cell autonomous Cell Line, Transformed Choline O-Acetyltransferase - metabolism Disease Models, Animal Gene Expression Regulation, Developmental - genetics Glial Cell Line-Derived Neurotrophic Factor - metabolism Glial Fibrillary Acidic Protein - metabolism Humans Mice Mice, Transgenic motor neurons Muscular Atrophy, Spinal - genetics Muscular Atrophy, Spinal - pathology Mutation - genetics Nestin - metabolism Neurons Pathology Pluripotent Stem Cells - metabolism Receptors, Purinergic P2Y2 - metabolism Rodents S100 Proteins - metabolism Spinal cord Spinal Cord - cytology stem cells Survival of Motor Neuron 1 Protein - genetics Survival of Motor Neuron 2 Protein - metabolism
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