Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics

A genome-wide association (GWA) study of treatment outcomes (response and remission) of selective serotonin reuptake inhibitors (SSRIs) was conducted using 529 subjects with major depressive disorder. While no SNP associations reached the genome-wide level of significance, 14 SNPs of interest were i...

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Veröffentlicht in:	The pharmacogenomics journal 2013-10, Vol.13 (5), p.456-463
Hauptverfasser:	Ji, Y, Biernacka, J M, Hebbring, S, Chai, Y, Jenkins, G D, Batzler, A, Snyder, K A, Drews, M S, Desta, Z, Flockhart, D, Mushiroda, T, Kubo, M, Nakamura, Y, Kamatani, N, Schaid, D, Weinshilboum, R M, Mrazek, D A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/191 631/208/205/2138 692/699/476/1414 692/700/565/1436/434 Adult Antidepressants Biomedical and Life Sciences Biomedicine Care and treatment Chromosome 10 Chromosome 9 Chromosomes, Human, Pair 10 Chromosomes, Human, Pair 9 Clinical outcomes Depressive Disorder, Major - drug therapy Depressive Disorder, Major - genetics Depressive Disorder, Major - metabolism Electrophoretic mobility Female G protein-coupled receptor kinase G-Protein-Coupled Receptor Kinase 5 - genetics Gene Expression Genetic aspects Genome-Wide Association Study - methods Genomes Genomics Genomics - methods Human Genetics Humans Identification and classification Kinases Major depressive disorder Male Mental depression Oncology original-article Patient outcomes Pharmacogenetics - methods Pharmacogenomics Pharmacotherapy Phosphotransferases (Alcohol Group Acceptor) - genetics Polymorphism, Single Nucleotide - genetics Psychopharmacology Remission Reporter gene Riboflavin Riboflavin kinase Serotonin - genetics Serotonin - metabolism Serotonin uptake inhibitors Serotonin Uptake Inhibitors - therapeutic use Single nucleotide polymorphisms Single-nucleotide polymorphism Transcription Transcription, Genetic Treatment Outcome
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