Higher Prevalence and More Severe Coronary Artery Disease in Hepatitis C Virus-infected Patients: A Case Control Study

Higher Prevalence and More Severe Coronary Artery Disease in Hepatitis C Virus-infected Patients: A Case Control Study

Background An association of Coronary artery disease (CAD) with hepatitis C (HCV) has been suggested, but definitive data are still lacking. Aim Our study sought to estimate the prevalence and severity of CAD in HCV patients compared to with age-, sex-, and race-matched controls without HCV infectio...

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Veröffentlicht in:Journal of clinical and experimental hepatology 2013-09, Vol.3 (3), p.186-191
Hauptverfasser: Satapathy, Sanjaya K, Kim, Yun Ju, Kataria, Ashish, Shifteh, Arash, Bhansali, Rohan, Cerulli, Maurice A, Bernstein, David
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coronary artery disease
Endocrinology & Metabolism
Gastroenterology and Hepatology
hepatitis C
Original
prevalence
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container_end_page 191
container_issue 3
container_start_page 186
container_title Journal of clinical and experimental hepatology
container_volume 3
creator Satapathy, Sanjaya K
Kim, Yun Ju
Kataria, Ashish
Shifteh, Arash
Bhansali, Rohan
Cerulli, Maurice A
Bernstein, David
description Background An association of Coronary artery disease (CAD) with hepatitis C (HCV) has been suggested, but definitive data are still lacking. Aim Our study sought to estimate the prevalence and severity of CAD in HCV patients compared to with age-, sex-, and race-matched controls without HCV infection. Subjects and methods 63 HCV-infected patients were compared with 63 age, race, and sex-matched controls without HCV infection undergoing coronary angiography for evaluation of CAD. CAD was defined as more than a 50% blockage in any of the proximal coronary arteries on angiogram. The severity of the stenosis was defined by the modified Reardon severity scoring system:
doi_str_mv 10.1016/j.jceh.2013.05.004
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Aim Our study sought to estimate the prevalence and severity of CAD in HCV patients compared to with age-, sex-, and race-matched controls without HCV infection. Subjects and methods 63 HCV-infected patients were compared with 63 age, race, and sex-matched controls without HCV infection undergoing coronary angiography for evaluation of CAD. CAD was defined as more than a 50% blockage in any of the proximal coronary arteries on angiogram. The severity of the stenosis was defined by the modified Reardon severity scoring system: &lt;50% stenosis of the luminal diameter, 1 point; 50–74%, 2 points; 75–99%, 3 points; 100% or total obstruction, 4 points. The points for each lesion in the proximal coronary circulation were summed to give the score for severity. Results A significantly higher prevalence of CAD was noted in the HCV population (69.8% vs. 47.6%, = 0.01). The combined Reardon's severity score in the HCV group was significantly higher compared to the controls (6.26 ± 5.39 vs. 2.6 ± 3.03, P  &lt; 0.0005). Additionally, significant multivessel CAD (&gt;50% stenosis and ≥2 vessels involved) was also noted significantly more commonly in the HCV group compared to controls (57.1% vs. 15.9%, P  &lt; 0.0005). Conclusion In this retrospective study the prevalence and severity of CAD was higher in HCV patients who were evaluated for CAD by angiogram compared with matched non-HCV patients. HCV-positive status is potentially a risk factor for CAD.</description><identifier>ISSN: 0973-6883</identifier><identifier>EISSN: 2213-3453</identifier><identifier>DOI: 10.1016/j.jceh.2013.05.004</identifier><identifier>PMID: 25755499</identifier><language>eng</language><publisher>India: Elsevier B.V</publisher><subject>coronary artery disease ; Endocrinology &amp; Metabolism ; Gastroenterology and Hepatology ; hepatitis C ; Original ; prevalence</subject><ispartof>Journal of clinical and experimental hepatology, 2013-09, Vol.3 (3), p.186-191</ispartof><rights>INASL</rights><rights>2013 INASL</rights><rights>2013, INASL. 2013 INASL</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-79b59b0d9446183fc5f86213b8bfe9b2b740af776267753978919c6f073b382d3</citedby><cites>FETCH-LOGICAL-c510t-79b59b0d9446183fc5f86213b8bfe9b2b740af776267753978919c6f073b382d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940268/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940268/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25755499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Satapathy, Sanjaya K</creatorcontrib><creatorcontrib>Kim, Yun Ju</creatorcontrib><creatorcontrib>Kataria, Ashish</creatorcontrib><creatorcontrib>Shifteh, Arash</creatorcontrib><creatorcontrib>Bhansali, Rohan</creatorcontrib><creatorcontrib>Cerulli, Maurice A</creatorcontrib><creatorcontrib>Bernstein, David</creatorcontrib><title>Higher Prevalence and More Severe Coronary Artery Disease in Hepatitis C Virus-infected Patients: A Case Control Study</title><title>Journal of clinical and experimental hepatology</title><addtitle>J Clin Exp Hepatol</addtitle><description>Background An association of Coronary artery disease (CAD) with hepatitis C (HCV) has been suggested, but definitive data are still lacking. Aim Our study sought to estimate the prevalence and severity of CAD in HCV patients compared to with age-, sex-, and race-matched controls without HCV infection. Subjects and methods 63 HCV-infected patients were compared with 63 age, race, and sex-matched controls without HCV infection undergoing coronary angiography for evaluation of CAD. CAD was defined as more than a 50% blockage in any of the proximal coronary arteries on angiogram. The severity of the stenosis was defined by the modified Reardon severity scoring system: &lt;50% stenosis of the luminal diameter, 1 point; 50–74%, 2 points; 75–99%, 3 points; 100% or total obstruction, 4 points. The points for each lesion in the proximal coronary circulation were summed to give the score for severity. Results A significantly higher prevalence of CAD was noted in the HCV population (69.8% vs. 47.6%, = 0.01). The combined Reardon's severity score in the HCV group was significantly higher compared to the controls (6.26 ± 5.39 vs. 2.6 ± 3.03, P  &lt; 0.0005). Additionally, significant multivessel CAD (&gt;50% stenosis and ≥2 vessels involved) was also noted significantly more commonly in the HCV group compared to controls (57.1% vs. 15.9%, P  &lt; 0.0005). Conclusion In this retrospective study the prevalence and severity of CAD was higher in HCV patients who were evaluated for CAD by angiogram compared with matched non-HCV patients. HCV-positive status is potentially a risk factor for CAD.</description><subject>coronary artery disease</subject><subject>Endocrinology &amp; Metabolism</subject><subject>Gastroenterology and Hepatology</subject><subject>hepatitis C</subject><subject>Original</subject><subject>prevalence</subject><issn>0973-6883</issn><issn>2213-3453</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kk2P0zAQhiMEYqtl_wAH5COXFH_EdozQSlX4KNIiVipwtRxnsnVJ7a6dVOq_x1GXFXDAlznMO69n5pmieEnwkmAi3uyWOwvbJcWELTFfYlw9KRaUElayirOnxQIryUpR1-yiuEpph_MTmFaYPi8uKJecV0otiuPa3W0hotsIRzOAt4CM79CXEAFt4Ag5NCEGb-IJreIIObx3CUwC5Dxaw8GMbnQJNeiHi1Mqne_BjtCh25wAP6a3aIWaWd4EP8YwoM04dacXxbPeDAmuHuJl8f3jh2_Nurz5-ulzs7opLSd4LKVquWpxp6pKkJr1lve1yDO2dduDamkrK2x6KQUVUnKmZK2IsqLHkrWsph27LK7Pvoep3UNnc0fRDPoQ3T5PpINx-u-Md1t9F46aqbwpUWeD1w8GMdxPkEa9d8nCMBgPYUqaCEErRpTEWUrPUhtDShH6x28I1jMzvdMzMz0z05jrzCwXvfqzwceS34Sy4N1ZAHlNRwdRJ-tmTp2LedO6C-7__tf_lNvBeWfN8BNOkHZhij4D0EQnqrHezFczHw1hGHNOGPsFaGW84Q</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Satapathy, Sanjaya K</creator><creator>Kim, Yun Ju</creator><creator>Kataria, Ashish</creator><creator>Shifteh, Arash</creator><creator>Bhansali, Rohan</creator><creator>Cerulli, Maurice A</creator><creator>Bernstein, David</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130901</creationdate><title>Higher Prevalence and More Severe Coronary Artery Disease in Hepatitis C Virus-infected Patients: A Case Control Study</title><author>Satapathy, Sanjaya K ; Kim, Yun Ju ; Kataria, Ashish ; Shifteh, Arash ; Bhansali, Rohan ; Cerulli, Maurice A ; Bernstein, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-79b59b0d9446183fc5f86213b8bfe9b2b740af776267753978919c6f073b382d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>coronary artery disease</topic><topic>Endocrinology &amp; Metabolism</topic><topic>Gastroenterology and Hepatology</topic><topic>hepatitis C</topic><topic>Original</topic><topic>prevalence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Satapathy, Sanjaya K</creatorcontrib><creatorcontrib>Kim, Yun Ju</creatorcontrib><creatorcontrib>Kataria, Ashish</creatorcontrib><creatorcontrib>Shifteh, Arash</creatorcontrib><creatorcontrib>Bhansali, Rohan</creatorcontrib><creatorcontrib>Cerulli, Maurice A</creatorcontrib><creatorcontrib>Bernstein, David</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical and experimental hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Satapathy, Sanjaya K</au><au>Kim, Yun Ju</au><au>Kataria, Ashish</au><au>Shifteh, Arash</au><au>Bhansali, Rohan</au><au>Cerulli, Maurice A</au><au>Bernstein, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher Prevalence and More Severe Coronary Artery Disease in Hepatitis C Virus-infected Patients: A Case Control Study</atitle><jtitle>Journal of clinical and experimental hepatology</jtitle><addtitle>J Clin Exp Hepatol</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>3</volume><issue>3</issue><spage>186</spage><epage>191</epage><pages>186-191</pages><issn>0973-6883</issn><eissn>2213-3453</eissn><abstract>Background An association of Coronary artery disease (CAD) with hepatitis C (HCV) has been suggested, but definitive data are still lacking. Aim Our study sought to estimate the prevalence and severity of CAD in HCV patients compared to with age-, sex-, and race-matched controls without HCV infection. Subjects and methods 63 HCV-infected patients were compared with 63 age, race, and sex-matched controls without HCV infection undergoing coronary angiography for evaluation of CAD. CAD was defined as more than a 50% blockage in any of the proximal coronary arteries on angiogram. The severity of the stenosis was defined by the modified Reardon severity scoring system: &lt;50% stenosis of the luminal diameter, 1 point; 50–74%, 2 points; 75–99%, 3 points; 100% or total obstruction, 4 points. The points for each lesion in the proximal coronary circulation were summed to give the score for severity. Results A significantly higher prevalence of CAD was noted in the HCV population (69.8% vs. 47.6%, = 0.01). The combined Reardon's severity score in the HCV group was significantly higher compared to the controls (6.26 ± 5.39 vs. 2.6 ± 3.03, P  &lt; 0.0005). Additionally, significant multivessel CAD (&gt;50% stenosis and ≥2 vessels involved) was also noted significantly more commonly in the HCV group compared to controls (57.1% vs. 15.9%, P  &lt; 0.0005). Conclusion In this retrospective study the prevalence and severity of CAD was higher in HCV patients who were evaluated for CAD by angiogram compared with matched non-HCV patients. HCV-positive status is potentially a risk factor for CAD.</abstract><cop>India</cop><pub>Elsevier B.V</pub><pmid>25755499</pmid><doi>10.1016/j.jceh.2013.05.004</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects coronary artery disease
Endocrinology & Metabolism
Gastroenterology and Hepatology
hepatitis C
Original
prevalence
title Higher Prevalence and More Severe Coronary Artery Disease in Hepatitis C Virus-infected Patients: A Case Control Study
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