Paired Toll-like receptor agonists enhance vaccine therapy through induction of interleukin-12

Minimal requirements for generating effective immunity include the delivery of antigenic (signal 1) and costimulatory (signal 2) signals to T lymphocytes. Recently, a class of third signals, often delivered by antigen-presenting dendritic cells, has been shown to greatly enhance immune responses, es...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-06, Vol.68 (11), p.4045-4049
Hauptverfasser:	Zheng, Rongxiu, Cohen, Peter A, Paustian, Christopher A, Johnson, Terrence D, Lee, Walter T, Shu, Suyu, Koski, Gary K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Vaccines - therapeutic use Cell Separation Enzyme-Linked Immunosorbent Assay Female Interleukin-12 - biosynthesis Mice Mice, Inbred C57BL Toll-Like Receptors - agonists Vaccines - administration & dosage Vaccines - immunology
Online-Zugang:	Volltext
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