The plastic nature of the human bone–periodontal ligament–tooth fibrous joint
Abstract This study investigates bony protrusions within a narrowed periodontal ligament space (PDL-space) of a human bone–PDL–tooth fibrous joint by mapping structural, biochemical, and mechanical heterogeneity. Higher resolution structural characterization was achieved via complementary atomic for...
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| Veröffentlicht in: | Bone (New York, N.Y.) N.Y.), 2013-12, Vol.57 (2), p.455-467 |
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| creator | Ho, Sunita P Kurylo, Michael P Grandfield, Kathryn Hurng, Jonathan Herber, Ralf-Peter Ryder, Mark I Altoe, Virginia Aloni, Shaul Feng, Jian Q Webb, Samuel Marshall, Grayson W Curtis, Donald Andrews, Joy C Pianetta, Piero |
| description | Abstract This study investigates bony protrusions within a narrowed periodontal ligament space (PDL-space) of a human bone–PDL–tooth fibrous joint by mapping structural, biochemical, and mechanical heterogeneity. Higher resolution structural characterization was achieved via complementary atomic force microscopy (AFM), nano-transmission X-ray microscopy (nano-TXM), and microtomography (MicroXCT™). Structural heterogeneity was correlated to biochemical and elemental composition, illustrated via histochemistry and microprobe X-ray fluorescence analysis (μ-XRF), and mechanical heterogeneity evaluated by AFM-based nanoindentation. Results demonstrated that the narrowed PDL-space was due to invasion of bundle bone (BB) into PDL-space. Protruded BB had a wider range with higher elastic modulus values (2–8 GPa) compared to lamellar bone (0.8–6 GPa), and increased quantities of Ca, P and Zn as revealed by μ-XRF. Interestingly, the hygroscopic 10–30 μm interface between protruded BB and lamellar bone exhibited higher X-ray attenuation similar to cement lines and lamellae within bone. Localization of the small leucine rich proteoglycan biglycan (BGN) responsible for mineralization was observed at the PDL–bone interface and around the osteocyte lacunae. Based on these results, it can be argued that the LB–BB interface was the original site of PDL attachment, and that the genesis of protruded BB identified as protrusions occurred as a result of shift in strain. We emphasize the importance of bony protrusions within the context of organ function and that additional study is warranted. |
| doi_str_mv | 10.1016/j.bone.2013.09.007 |
| format | Article |
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Higher resolution structural characterization was achieved via complementary atomic force microscopy (AFM), nano-transmission X-ray microscopy (nano-TXM), and microtomography (MicroXCT™). Structural heterogeneity was correlated to biochemical and elemental composition, illustrated via histochemistry and microprobe X-ray fluorescence analysis (μ-XRF), and mechanical heterogeneity evaluated by AFM-based nanoindentation. Results demonstrated that the narrowed PDL-space was due to invasion of bundle bone (BB) into PDL-space. Protruded BB had a wider range with higher elastic modulus values (2–8 GPa) compared to lamellar bone (0.8–6 GPa), and increased quantities of Ca, P and Zn as revealed by μ-XRF. Interestingly, the hygroscopic 10–30 μm interface between protruded BB and lamellar bone exhibited higher X-ray attenuation similar to cement lines and lamellae within bone. Localization of the small leucine rich proteoglycan biglycan (BGN) responsible for mineralization was observed at the PDL–bone interface and around the osteocyte lacunae. Based on these results, it can be argued that the LB–BB interface was the original site of PDL attachment, and that the genesis of protruded BB identified as protrusions occurred as a result of shift in strain. We emphasize the importance of bony protrusions within the context of organ function and that additional study is warranted.</description><identifier>ISSN: 8756-3282</identifier><identifier>EISSN: 1873-2763</identifier><identifier>DOI: 10.1016/j.bone.2013.09.007</identifier><identifier>PMID: 24063947</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Alveolar bone ; Biglycan - metabolism ; Biological and medical sciences ; Biomechanical Phenomena ; Bone and Bones - diagnostic imaging ; Bone and Bones - physiology ; Bone and Bones - ultrastructure ; Bone functional adaptation ; Bone–PDL–tooth fibrous joint ; Bundle bone ; Calcium - metabolism ; Dental Cementum - diagnostic imaging ; Dental Cementum - physiology ; Discontinuities ; Elastic Modulus ; Extracellular Matrix Proteins - metabolism ; Fibromodulin ; Fluorescence ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunohistochemistry ; Joints - physiology ; Joints - ultrastructure ; Microscopy, Atomic Force ; Models, Biological ; Orthopedics ; Periodontal ligament ; Periodontal Ligament - cytology ; Periodontal Ligament - diagnostic imaging ; Periodontal Ligament - physiology ; Periodontal Ligament - ultrastructure ; Phosphorus - metabolism ; Proteoglycans - metabolism ; Surface Properties ; Tooth - diagnostic imaging ; Tooth - physiology ; Tooth - ultrastructure ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; X-Ray Microtomography ; Zinc - metabolism</subject><ispartof>Bone (New York, N.Y.), 2013-12, Vol.57 (2), p.455-467</ispartof><rights>2013</rights><rights>2015 INIST-CNRS</rights><rights>2013. Published by Elsevier Inc. All rights reserved.</rights><rights>2013 The Authors. Published by Elsevier Inc. All rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-800ab1a163d93464ad6cc3e57a79fa761fed0c074e12a930da373cfec2144a203</citedby><cites>FETCH-LOGICAL-c540t-800ab1a163d93464ad6cc3e57a79fa761fed0c074e12a930da373cfec2144a203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bone.2013.09.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27948297$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24063947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ho, Sunita P</creatorcontrib><creatorcontrib>Kurylo, Michael P</creatorcontrib><creatorcontrib>Grandfield, Kathryn</creatorcontrib><creatorcontrib>Hurng, Jonathan</creatorcontrib><creatorcontrib>Herber, Ralf-Peter</creatorcontrib><creatorcontrib>Ryder, Mark I</creatorcontrib><creatorcontrib>Altoe, Virginia</creatorcontrib><creatorcontrib>Aloni, Shaul</creatorcontrib><creatorcontrib>Feng, Jian Q</creatorcontrib><creatorcontrib>Webb, Samuel</creatorcontrib><creatorcontrib>Marshall, Grayson W</creatorcontrib><creatorcontrib>Curtis, Donald</creatorcontrib><creatorcontrib>Andrews, Joy C</creatorcontrib><creatorcontrib>Pianetta, Piero</creatorcontrib><title>The plastic nature of the human bone–periodontal ligament–tooth fibrous joint</title><title>Bone (New York, N.Y.)</title><addtitle>Bone</addtitle><description>Abstract This study investigates bony protrusions within a narrowed periodontal ligament space (PDL-space) of a human bone–PDL–tooth fibrous joint by mapping structural, biochemical, and mechanical heterogeneity. Higher resolution structural characterization was achieved via complementary atomic force microscopy (AFM), nano-transmission X-ray microscopy (nano-TXM), and microtomography (MicroXCT™). Structural heterogeneity was correlated to biochemical and elemental composition, illustrated via histochemistry and microprobe X-ray fluorescence analysis (μ-XRF), and mechanical heterogeneity evaluated by AFM-based nanoindentation. Results demonstrated that the narrowed PDL-space was due to invasion of bundle bone (BB) into PDL-space. Protruded BB had a wider range with higher elastic modulus values (2–8 GPa) compared to lamellar bone (0.8–6 GPa), and increased quantities of Ca, P and Zn as revealed by μ-XRF. Interestingly, the hygroscopic 10–30 μm interface between protruded BB and lamellar bone exhibited higher X-ray attenuation similar to cement lines and lamellae within bone. Localization of the small leucine rich proteoglycan biglycan (BGN) responsible for mineralization was observed at the PDL–bone interface and around the osteocyte lacunae. Based on these results, it can be argued that the LB–BB interface was the original site of PDL attachment, and that the genesis of protruded BB identified as protrusions occurred as a result of shift in strain. We emphasize the importance of bony protrusions within the context of organ function and that additional study is warranted.</description><subject>Alveolar bone</subject><subject>Biglycan - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone and Bones - physiology</subject><subject>Bone and Bones - ultrastructure</subject><subject>Bone functional adaptation</subject><subject>Bone–PDL–tooth fibrous joint</subject><subject>Bundle bone</subject><subject>Calcium - metabolism</subject><subject>Dental Cementum - diagnostic imaging</subject><subject>Dental Cementum - physiology</subject><subject>Discontinuities</subject><subject>Elastic Modulus</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Fibromodulin</subject><subject>Fluorescence</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Joints - physiology</subject><subject>Joints - ultrastructure</subject><subject>Microscopy, Atomic Force</subject><subject>Models, Biological</subject><subject>Orthopedics</subject><subject>Periodontal ligament</subject><subject>Periodontal Ligament - cytology</subject><subject>Periodontal Ligament - diagnostic imaging</subject><subject>Periodontal Ligament - physiology</subject><subject>Periodontal Ligament - ultrastructure</subject><subject>Phosphorus - metabolism</subject><subject>Proteoglycans - metabolism</subject><subject>Surface Properties</subject><subject>Tooth - diagnostic imaging</subject><subject>Tooth - physiology</subject><subject>Tooth - ultrastructure</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>X-Ray Microtomography</subject><subject>Zinc - metabolism</subject><issn>8756-3282</issn><issn>1873-2763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kt2K1TAQx4so7nH1BbyQ3gjetOarTQOysCx-wYKI63WYk073pLbJMUkX9s538A19ElPOcf248Cow-c38Z-Y_RfGUkpoS2r4c6613WDNCeU1UTYi8V2xoJ3nFZMvvF5tONm3FWcdOikcxjoQQriR9WJwwQVquhNwUH692WO4niMma0kFaApZ-KFOO7pYZXLlK_Pj2fY_B-t67BFM52WuY0aUcTt6nXTnYbfBLLEdvXXpcPBhgivjk-J4Wn9-8vrp4V11-ePv-4vyyMo0gqeoIgS0F2vJecdEK6FtjODYSpBpAtnTAnhgiBVIGipMeuORmQMOoEMAIPy3ODnX3y3bG3uSGAkx6H-wM4VZ7sPrvH2d3-trfaK54p1qZC7w4Fgj-64Ix6dlGg9MEDvM0OusoJlXDREbZATXBxxhwuJOhRK9e6FGvi9KrF5oonb3ISc_-bPAu5dfyM_D8CEA0MA0BnLHxNyeV6JhauVcHDvM6bywGHY1FZ7C3AU3Svbf_7-Psn3QzWWez4he8xTj6JbhslKY6Mk30p_Vq1qOhPN9Loyj_CR1LwF4</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Ho, Sunita P</creator><creator>Kurylo, Michael P</creator><creator>Grandfield, Kathryn</creator><creator>Hurng, Jonathan</creator><creator>Herber, Ralf-Peter</creator><creator>Ryder, Mark I</creator><creator>Altoe, Virginia</creator><creator>Aloni, Shaul</creator><creator>Feng, Jian Q</creator><creator>Webb, Samuel</creator><creator>Marshall, Grayson W</creator><creator>Curtis, Donald</creator><creator>Andrews, Joy C</creator><creator>Pianetta, Piero</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20131201</creationdate><title>The plastic nature of the human bone–periodontal ligament–tooth fibrous joint</title><author>Ho, Sunita P ; Kurylo, Michael P ; Grandfield, Kathryn ; Hurng, Jonathan ; Herber, Ralf-Peter ; Ryder, Mark I ; Altoe, Virginia ; Aloni, Shaul ; Feng, Jian Q ; Webb, Samuel ; Marshall, Grayson W ; Curtis, Donald ; Andrews, Joy C ; Pianetta, Piero</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-800ab1a163d93464ad6cc3e57a79fa761fed0c074e12a930da373cfec2144a203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alveolar bone</topic><topic>Biglycan - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomechanical Phenomena</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone and Bones - physiology</topic><topic>Bone and Bones - ultrastructure</topic><topic>Bone functional adaptation</topic><topic>Bone–PDL–tooth fibrous joint</topic><topic>Bundle bone</topic><topic>Calcium - metabolism</topic><topic>Dental Cementum - diagnostic imaging</topic><topic>Dental Cementum - physiology</topic><topic>Discontinuities</topic><topic>Elastic Modulus</topic><topic>Extracellular Matrix Proteins - metabolism</topic><topic>Fibromodulin</topic><topic>Fluorescence</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Joints - physiology</topic><topic>Joints - ultrastructure</topic><topic>Microscopy, Atomic Force</topic><topic>Models, Biological</topic><topic>Orthopedics</topic><topic>Periodontal ligament</topic><topic>Periodontal Ligament - cytology</topic><topic>Periodontal Ligament - diagnostic imaging</topic><topic>Periodontal Ligament - physiology</topic><topic>Periodontal Ligament - ultrastructure</topic><topic>Phosphorus - metabolism</topic><topic>Proteoglycans - metabolism</topic><topic>Surface Properties</topic><topic>Tooth - diagnostic imaging</topic><topic>Tooth - physiology</topic><topic>Tooth - ultrastructure</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>X-Ray Microtomography</topic><topic>Zinc - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ho, Sunita P</creatorcontrib><creatorcontrib>Kurylo, Michael P</creatorcontrib><creatorcontrib>Grandfield, Kathryn</creatorcontrib><creatorcontrib>Hurng, Jonathan</creatorcontrib><creatorcontrib>Herber, Ralf-Peter</creatorcontrib><creatorcontrib>Ryder, Mark I</creatorcontrib><creatorcontrib>Altoe, Virginia</creatorcontrib><creatorcontrib>Aloni, Shaul</creatorcontrib><creatorcontrib>Feng, Jian Q</creatorcontrib><creatorcontrib>Webb, Samuel</creatorcontrib><creatorcontrib>Marshall, Grayson W</creatorcontrib><creatorcontrib>Curtis, Donald</creatorcontrib><creatorcontrib>Andrews, Joy C</creatorcontrib><creatorcontrib>Pianetta, Piero</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Bone (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ho, Sunita P</au><au>Kurylo, Michael P</au><au>Grandfield, Kathryn</au><au>Hurng, Jonathan</au><au>Herber, Ralf-Peter</au><au>Ryder, Mark I</au><au>Altoe, Virginia</au><au>Aloni, Shaul</au><au>Feng, Jian Q</au><au>Webb, Samuel</au><au>Marshall, Grayson W</au><au>Curtis, Donald</au><au>Andrews, Joy C</au><au>Pianetta, Piero</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The plastic nature of the human bone–periodontal ligament–tooth fibrous joint</atitle><jtitle>Bone (New York, N.Y.)</jtitle><addtitle>Bone</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>57</volume><issue>2</issue><spage>455</spage><epage>467</epage><pages>455-467</pages><issn>8756-3282</issn><eissn>1873-2763</eissn><abstract>Abstract This study investigates bony protrusions within a narrowed periodontal ligament space (PDL-space) of a human bone–PDL–tooth fibrous joint by mapping structural, biochemical, and mechanical heterogeneity. Higher resolution structural characterization was achieved via complementary atomic force microscopy (AFM), nano-transmission X-ray microscopy (nano-TXM), and microtomography (MicroXCT™). Structural heterogeneity was correlated to biochemical and elemental composition, illustrated via histochemistry and microprobe X-ray fluorescence analysis (μ-XRF), and mechanical heterogeneity evaluated by AFM-based nanoindentation. Results demonstrated that the narrowed PDL-space was due to invasion of bundle bone (BB) into PDL-space. Protruded BB had a wider range with higher elastic modulus values (2–8 GPa) compared to lamellar bone (0.8–6 GPa), and increased quantities of Ca, P and Zn as revealed by μ-XRF. Interestingly, the hygroscopic 10–30 μm interface between protruded BB and lamellar bone exhibited higher X-ray attenuation similar to cement lines and lamellae within bone. Localization of the small leucine rich proteoglycan biglycan (BGN) responsible for mineralization was observed at the PDL–bone interface and around the osteocyte lacunae. Based on these results, it can be argued that the LB–BB interface was the original site of PDL attachment, and that the genesis of protruded BB identified as protrusions occurred as a result of shift in strain. We emphasize the importance of bony protrusions within the context of organ function and that additional study is warranted.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>24063947</pmid><doi>10.1016/j.bone.2013.09.007</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alveolar bone Biglycan - metabolism Biological and medical sciences Biomechanical Phenomena Bone and Bones - diagnostic imaging Bone and Bones - physiology Bone and Bones - ultrastructure Bone functional adaptation Bone–PDL–tooth fibrous joint Bundle bone Calcium - metabolism Dental Cementum - diagnostic imaging Dental Cementum - physiology Discontinuities Elastic Modulus Extracellular Matrix Proteins - metabolism Fibromodulin Fluorescence Fundamental and applied biological sciences. Psychology Humans Immunohistochemistry Joints - physiology Joints - ultrastructure Microscopy, Atomic Force Models, Biological Orthopedics Periodontal ligament Periodontal Ligament - cytology Periodontal Ligament - diagnostic imaging Periodontal Ligament - physiology Periodontal Ligament - ultrastructure Phosphorus - metabolism Proteoglycans - metabolism Surface Properties Tooth - diagnostic imaging Tooth - physiology Tooth - ultrastructure Vertebrates: anatomy and physiology, studies on body, several organs or systems X-Ray Microtomography Zinc - metabolism |
| title | The plastic nature of the human bone–periodontal ligament–tooth fibrous joint |
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