Mibampator (LY451395) randomized clinical trial for agitation/aggression in Alzheimer's disease

Background: Mibampator, an amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor potentiator, was evaluated for treatment of agitation and aggression (A/A) in Alzheimer's disease (AD). Methods: Outpatients (n = 132) with probable AD and A/A randomized to 12 weeks of double-blind treatmen...

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Veröffentlicht in:	International psychogeriatrics 2013-05, Vol.25 (5), p.707-719
Hauptverfasser:	Trzepacz, Paula T., Cummings, Jeffrey, Konechnik, Thomas, Forrester, Tammy D., Chang, Curtis, Dennehy, Ellen B., Willis, Brian A., Shuler, Catherine, Tabas, Linda B., Lyketsos, Constantine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Aged Aged, 80 and over Aggression - drug effects Aggression - psychology Alzheimer Disease - complications Alzheimer Disease - drug therapy Alzheimer Disease - psychology Alzheimer's disease Biological and medical sciences Biphenyl Compounds - pharmacology Biphenyl Compounds - therapeutic use Clinical outcomes Clinical trials Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Double-Blind Method Drug therapy Female Geriatric psychology Geriatrics Humans Male Medical sciences Middle Aged Neurology Neuropsychological Tests Older people Organic mental disorders. Neuropsychology Outpatients Psychology. Psychoanalysis. Psychiatry Psychomotor Agitation - drug therapy Psychomotor Agitation - etiology Psychomotor Agitation - psychology Psychopathology. Psychiatry Sulfonamides - pharmacology Sulfonamides - therapeutic use Surveys and Questionnaires Treatment Outcome
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