Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement

Nuclei move to specific locations to polarize migrating and differentiating cells. Many nuclear movements are microtubule-dependent. However, nuclear movement to reorient the centrosome in migrating fibroblasts occurs through an unknown actin-dependent mechanism. We found that linear arrays of outer...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2010-08, Vol.329 (5994), p.956-959
Hauptverfasser:	Luxton, G.W. Gant, Gomes, Edgar R, Folker, Eric S, Vintinner, Erin, Gundersen, Gregg G
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Actins - metabolism Animals Arrays Biological and medical sciences Cables Cell lines Cell Movement - physiology Cell nucleus Cell Nucleus - metabolism Cell structures and functions Cells Centrosome - physiology Centrosomes Cytoskeleton, cytoplasm. Intracellular movements Fibroblasts Fluorescence Fundamental and applied biological sciences. Psychology Harnesses Joining Linear arrays Lysophospholipids - metabolism Matrix materials Membrane Proteins - metabolism Membranes Mice Molecular and cellular biology Movement Nerve Tissue Proteins - metabolism Neurons NIH 3T3 Cells Nuclear Envelope - metabolism Nuclear membrane Nuclear Proteins - metabolism Proteins Telomere-Binding Proteins - metabolism
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