The epoxyeicosatrienoic acid-stimulated phosphorylation of EGF-R involves the activation of metalloproteinases and the release of HB-EGF in cancer cells

Aim： To test the hypothesis that the epoxyeicosatrienoicacid （EET）-induced transactivation of EGF-R depends on the activation of metal- Ioproteinases and the subsequent release of HB-EGF in cancer cells. Methods： Exogenous 14,15-EET were added to four human-derived cancer cell lines Tca-8113, A549,...

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