A Nucleotide-dependent and HRDC Domain-dependent Structural Transition in DNA-bound RecQ Helicase

The allosteric communication between the ATP- and DNA-binding sites of RecQ helicases enables efficient coupling of ATP hydrolysis to translocation along single-stranded DNA (ssDNA) and, in turn, the restructuring of multistranded DNA substrates during genome maintenance processes. In this study, we...

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Veröffentlicht in:	The Journal of biological chemistry 2014-02, Vol.289 (9), p.5938-5949
Hauptverfasser:	Kocsis, Zsuzsa S., Sarlós, Kata, Harami, Gábor M., Martina, Máté, Kovács, Mihály
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - analogs & derivatives Adenosine Diphosphate - chemistry ATPases DNA and Chromosomes DNA Repair DNA, Bacterial - chemistry DNA, Bacterial - genetics DNA, Bacterial - metabolism DNA, Single-Stranded - chemistry DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism DNA-Protein Interaction Escherichia coli - enzymology Escherichia coli - genetics Kinetics Molecular Motors Organometallic Compounds - chemistry Protein Conformation Protein Structure, Tertiary Recombination RecQ Helicases - chemistry RecQ Helicases - genetics RecQ Helicases - metabolism Ribonuclease III - chemistry Structure
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