Targeting O-Glycosyltransferase (OGT) to Promote Healing of Diabetic Skin Wounds

Non-healing wounds are a significant source of morbidity. This is particularly true for diabetic patients, who tend to develop chronic skin wounds. O-GlcNAc modification of serine and threonine residues is a common regulatory post-translational modification analogous to protein phosphorylation; incr...

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Veröffentlicht in:The Journal of biological chemistry 2014-02, Vol.289 (9), p.5462-5466
Hauptverfasser: Runager, Kasper, Bektas, Meryem, Berkowitz, Paula, Rubenstein, David S.
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Sprache:eng
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