Association of Nocturnal Melatonin Secretion With Insulin Resistance in Nondiabetic Young Women
Exogenous melatonin ameliorates insulin resistance in animals, while among humans, polymorphisms in the melatonin receptor gene are associated with insulin resistance. We aimed to investigate the association of endogenous nocturnal melatonin secretion with insulin resistance in humans. We analyzed t...
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| Veröffentlicht in: | American journal of epidemiology 2013-07, Vol.178 (2), p.231-238 |
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| creator | MCMULLAN, Ciaran J CURHAN, Gary C SCHERNHAMMER, Eva S FORMAN, John P |
| description | Exogenous melatonin ameliorates insulin resistance in animals, while among humans, polymorphisms in the melatonin receptor gene are associated with insulin resistance. We aimed to investigate the association of endogenous nocturnal melatonin secretion with insulin resistance in humans. We analyzed the association between endogenous nocturnal melatonin secretion, estimated by measuring the main melatonin metabolite, 6-sulfatoxymelatonin, from the first morning urinary void, and the prevalence of insulin resistance based on fasting blood samples collected in a cross-sectional study of 1,075 US women (1997-1999) without diabetes, hypertension, or malignancy. Urinary 6-sulfatoxymelatonin level was standardized to urinary creatinine level; insulin resistance was defined as an insulin sensitivity index value (using the McAuley formula) less than 7.85. Logistic regression models included adjustment for age, body mass index, smoking, physical activity, alcohol intake, dietary glycemic index, family history of diabetes mellitus, blood pressure, plasma total cholesterol, uric acid, and estimated glomerular filtration rate. Higher nocturnal melatonin secretion was inversely associated with insulin levels and insulin resistance. In fully adjusted models, the odds ratio for insulin resistance was 0.45 (95% confidence interval: 0.28, 0.74) among women in the highest quartile of urinary 6-sulfatoxymelatonin:creatinine ratio compared with women in the lowest quartile. Nocturnal melatonin secretion is independently and inversely associated with insulin resistance. |
| doi_str_mv | 10.1093/aje/kws470 |
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We aimed to investigate the association of endogenous nocturnal melatonin secretion with insulin resistance in humans. We analyzed the association between endogenous nocturnal melatonin secretion, estimated by measuring the main melatonin metabolite, 6-sulfatoxymelatonin, from the first morning urinary void, and the prevalence of insulin resistance based on fasting blood samples collected in a cross-sectional study of 1,075 US women (1997-1999) without diabetes, hypertension, or malignancy. Urinary 6-sulfatoxymelatonin level was standardized to urinary creatinine level; insulin resistance was defined as an insulin sensitivity index value (using the McAuley formula) less than 7.85. Logistic regression models included adjustment for age, body mass index, smoking, physical activity, alcohol intake, dietary glycemic index, family history of diabetes mellitus, blood pressure, plasma total cholesterol, uric acid, and estimated glomerular filtration rate. Higher nocturnal melatonin secretion was inversely associated with insulin levels and insulin resistance. In fully adjusted models, the odds ratio for insulin resistance was 0.45 (95% confidence interval: 0.28, 0.74) among women in the highest quartile of urinary 6-sulfatoxymelatonin:creatinine ratio compared with women in the lowest quartile. Nocturnal melatonin secretion is independently and inversely associated with insulin resistance.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kws470</identifier><identifier>PMID: 23813704</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Biological and medical sciences ; Biomarkers - urine ; Circadian Rhythm ; Cross-Sectional Studies ; Diabetes ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Epidemiology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; General aspects ; Health Surveys ; Humans ; Insulin resistance ; Insulin Resistance - physiology ; Logistic Models ; Medical research ; Medical sciences ; Melatonin ; Melatonin - analogs & derivatives ; Melatonin - urine ; Middle Aged ; Miscellaneous ; Odds Ratio ; Original Contributions ; Public health. Hygiene ; Public health. Hygiene-occupational medicine</subject><ispartof>American journal of epidemiology, 2013-07, Vol.178 (2), p.231-238</ispartof><rights>2014 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Jul 15, 2013</rights><rights>The Author 2013. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-5a9c0a237a51eca8aa135130aa3a003d1bcff5c2f08abb2922d3119d167a8c313</citedby><cites>FETCH-LOGICAL-c436t-5a9c0a237a51eca8aa135130aa3a003d1bcff5c2f08abb2922d3119d167a8c313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27822802$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23813704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MCMULLAN, Ciaran J</creatorcontrib><creatorcontrib>CURHAN, Gary C</creatorcontrib><creatorcontrib>SCHERNHAMMER, Eva S</creatorcontrib><creatorcontrib>FORMAN, John P</creatorcontrib><title>Association of Nocturnal Melatonin Secretion With Insulin Resistance in Nondiabetic Young Women</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>Exogenous melatonin ameliorates insulin resistance in animals, while among humans, polymorphisms in the melatonin receptor gene are associated with insulin resistance. We aimed to investigate the association of endogenous nocturnal melatonin secretion with insulin resistance in humans. We analyzed the association between endogenous nocturnal melatonin secretion, estimated by measuring the main melatonin metabolite, 6-sulfatoxymelatonin, from the first morning urinary void, and the prevalence of insulin resistance based on fasting blood samples collected in a cross-sectional study of 1,075 US women (1997-1999) without diabetes, hypertension, or malignancy. Urinary 6-sulfatoxymelatonin level was standardized to urinary creatinine level; insulin resistance was defined as an insulin sensitivity index value (using the McAuley formula) less than 7.85. Logistic regression models included adjustment for age, body mass index, smoking, physical activity, alcohol intake, dietary glycemic index, family history of diabetes mellitus, blood pressure, plasma total cholesterol, uric acid, and estimated glomerular filtration rate. Higher nocturnal melatonin secretion was inversely associated with insulin levels and insulin resistance. In fully adjusted models, the odds ratio for insulin resistance was 0.45 (95% confidence interval: 0.28, 0.74) among women in the highest quartile of urinary 6-sulfatoxymelatonin:creatinine ratio compared with women in the lowest quartile. Nocturnal melatonin secretion is independently and inversely associated with insulin resistance.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - urine</subject><subject>Circadian Rhythm</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Epidemiology</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>General aspects</subject><subject>Health Surveys</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Logistic Models</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Melatonin</subject><subject>Melatonin - analogs & derivatives</subject><subject>Melatonin - urine</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Odds Ratio</subject><subject>Original Contributions</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0V1LHDEUBuBQKnW79sYfIAOlIMLUc5L5vBFErC74AWqRXoUzmYxmnU1sMtPivze6q7VehSQPL8l5GdtE-I5Qi12a6927vyEr4QObYFYWacHz4iObAABPa17wdfY5hDkAYp3DJ7bORYWihGzC5H4IThkajLOJ65Izp4bRW-qTU93T4KyxyaVWXj-DazPcJjMbxj4eX-hgwkBW6STuzpxtDTXRqeSXG-1Ncu0W2m6wtY76oL-s1in7-ePw6uA4PTk_mh3sn6QqE8WQ5lQrIC5KylErqohQ5CiASBCAaLFRXZcr3kFFTcNrzlsRP9NiUVKlBIop21vm3o_NQrdK28FTL--9WZB_kI6M_P_Gmlt54_5IUYsyr6sYsL0K8O73qMMgFyYo3fdktRuDxAzisKHCItKv7-jcPc_sSWFMA455VDtLpbwLwevu9TEI8qk3GXuTy94i3nr7_Ff6UlQE31aAgqK-83HuJvxzZcV5BVw8Ag-aoqU</recordid><startdate>20130715</startdate><enddate>20130715</enddate><creator>MCMULLAN, Ciaran J</creator><creator>CURHAN, Gary C</creator><creator>SCHERNHAMMER, Eva S</creator><creator>FORMAN, John P</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130715</creationdate><title>Association of Nocturnal Melatonin Secretion With Insulin Resistance in Nondiabetic Young Women</title><author>MCMULLAN, Ciaran J ; CURHAN, Gary C ; SCHERNHAMMER, Eva S ; FORMAN, John P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-5a9c0a237a51eca8aa135130aa3a003d1bcff5c2f08abb2922d3119d167a8c313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - urine</topic><topic>Circadian Rhythm</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Epidemiology</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>General aspects</topic><topic>Health Surveys</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Logistic Models</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Melatonin</topic><topic>Melatonin - analogs & derivatives</topic><topic>Melatonin - urine</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Odds Ratio</topic><topic>Original Contributions</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MCMULLAN, Ciaran J</creatorcontrib><creatorcontrib>CURHAN, Gary C</creatorcontrib><creatorcontrib>SCHERNHAMMER, Eva S</creatorcontrib><creatorcontrib>FORMAN, John P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MCMULLAN, Ciaran J</au><au>CURHAN, Gary C</au><au>SCHERNHAMMER, Eva S</au><au>FORMAN, John P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Nocturnal Melatonin Secretion With Insulin Resistance in Nondiabetic Young Women</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>2013-07-15</date><risdate>2013</risdate><volume>178</volume><issue>2</issue><spage>231</spage><epage>238</epage><pages>231-238</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>Exogenous melatonin ameliorates insulin resistance in animals, while among humans, polymorphisms in the melatonin receptor gene are associated with insulin resistance. We aimed to investigate the association of endogenous nocturnal melatonin secretion with insulin resistance in humans. We analyzed the association between endogenous nocturnal melatonin secretion, estimated by measuring the main melatonin metabolite, 6-sulfatoxymelatonin, from the first morning urinary void, and the prevalence of insulin resistance based on fasting blood samples collected in a cross-sectional study of 1,075 US women (1997-1999) without diabetes, hypertension, or malignancy. Urinary 6-sulfatoxymelatonin level was standardized to urinary creatinine level; insulin resistance was defined as an insulin sensitivity index value (using the McAuley formula) less than 7.85. Logistic regression models included adjustment for age, body mass index, smoking, physical activity, alcohol intake, dietary glycemic index, family history of diabetes mellitus, blood pressure, plasma total cholesterol, uric acid, and estimated glomerular filtration rate. Higher nocturnal melatonin secretion was inversely associated with insulin levels and insulin resistance. In fully adjusted models, the odds ratio for insulin resistance was 0.45 (95% confidence interval: 0.28, 0.74) among women in the highest quartile of urinary 6-sulfatoxymelatonin:creatinine ratio compared with women in the lowest quartile. Nocturnal melatonin secretion is independently and inversely associated with insulin resistance.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>23813704</pmid><doi>10.1093/aje/kws470</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Biomarkers - urine Circadian Rhythm Cross-Sectional Studies Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Female General aspects Health Surveys Humans Insulin resistance Insulin Resistance - physiology Logistic Models Medical research Medical sciences Melatonin Melatonin - analogs & derivatives Melatonin - urine Middle Aged Miscellaneous Odds Ratio Original Contributions Public health. Hygiene Public health. Hygiene-occupational medicine |
| title | Association of Nocturnal Melatonin Secretion With Insulin Resistance in Nondiabetic Young Women |
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