The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes

The precise regulation of S-phase-specific genes is critical for cell proliferation. How the repressive chromatin configuration mediated by the retinoblastoma protein and repressor E2F factors changes at the G1/S transition to allow transcription activation is unclear. Here we show ChIP-on-chip stud...

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Veröffentlicht in:	Nucleic acids research 2014-02, Vol.42 (4), p.2185-2196
Hauptverfasser:	Subtil-Rodríguez, Alicia, Vázquez-Chávez, Elena, Ceballos-Chávez, María, Rodríguez-Paredes, Manuel, Martín-Subero, José I, Esteller, Manel, Reyes, José C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell cycle Cell Line Cell proliferation Chromatin Cicle cel·lular Cromatina DNA-Binding Proteins - metabolism E2F Transcription Factors - metabolism E2F1 Transcription Factor - metabolism E2F3 Transcription Factor - metabolism Fixació de proteïnes Gene Regulation, Chromatin and Epigenetics Genetic transcription Histones Humans Proliferació cel·lular Promoter Regions, Genetic Protein binding S Phase - genetics Transcripció genètica Transcription Factors - metabolism Transcriptional Activation
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