Mechanistic aspects of inducible nitric oxide synthase-induced lung injury in burn trauma

Abstract Introduction Although the beneficial effects of inducible nitric oxide synthase (iNOS) inhibition in acute lung injury secondary to cutaneous burn and smoke inhalation were previously demonstrated, the mechanistic aspects are not completely understood. The objective of the present study is...

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Veröffentlicht in:	Burns 2011-06, Vol.37 (4), p.638-645
Hauptverfasser:	Enkhbaatar, Perenlei, Wang, Jianpu, Saunders, Fiona, Lange, Matthias, Hamahata, Atsumori, Rehberg, Sebastian, Parkinson, John F, Traber, Lillian D, Herndon, David N, Traber, Daniel L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences Burns Burns - drug therapy Burns - physiopathology Critical Care Disease Models, Animal Female Imidazoles - therapeutic use Immunohistochemistry Interleukin-8 - metabolism Lung - metabolism Lung - pathology Malondialdehyde - metabolism Medical sciences NF-kappa B - metabolism Nitric Oxide Synthase Type II - antagonists & inhibitors Peroxidase - metabolism Piperazines - therapeutic use Poly(ADP)ribose Pulmonary Gas Exchange - drug effects Pyrimidines - therapeutic use Reactive nitrogen species RNA, Messenger - metabolism Sheep Smoke Inhalation Injury - drug therapy Smoke Inhalation Injury - physiopathology Thermal injury Traumas. Diseases due to physical agents Tyrosine - analogs & derivatives Tyrosine - metabolism
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